ES368113A2 - Procedure for the production of indole derivatives - Google Patents
Procedure for the production of indole derivativesInfo
- Publication number
- ES368113A2 ES368113A2 ES368113A ES368113A ES368113A2 ES 368113 A2 ES368113 A2 ES 368113A2 ES 368113 A ES368113 A ES 368113A ES 368113 A ES368113 A ES 368113A ES 368113 A2 ES368113 A2 ES 368113A2
- Authority
- ES
- Spain
- Prior art keywords
- reacted
- general formula
- methyl
- procedure
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- XBVSGEGNQZAQPM-UHFFFAOYSA-N 2-methyl-1h-indol-4-ol Chemical compound C1=CC=C2NC(C)=CC2=C1O XBVSGEGNQZAQPM-UHFFFAOYSA-N 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- GKIPXFAANLTWBM-UHFFFAOYSA-N epibromohydrin Chemical compound BrCC1CO1 GKIPXFAANLTWBM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Landscapes
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Improvements introduced in the object of the main patent no. 322,453, granted on december 5, 1966, by: procedure for the production of indollic derivatives, of general formula i ** (see formula) ** Wherein r means hydrogen or methyl, characterized in that a) 4-hydroxy-2-methyl-indole is reacted, in an alkaline medium and in the absence of oxygen, with epichlorohydrin or epibronhydrin, the reaction product is reacted with an amine of general formula ii, ** (see formula) ** Or general formula iia, ** (see formula) ** In which formulas r has the above-indicated meaning and then any benzyl radical that is present is dissociated; b) an amine of general formula iia is reacted with epichlorohydrin or epibromohydrin, the reaction product is reacted in an alkaline medium and in the absence of oxygen with 4-hydroxy-2-methyl-indole and the mixture is then dissociated. Benzyl radical. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH133865A CH453363A (en) | 1965-02-01 | 1965-02-01 | Process for the production of new indole derivatives |
| ES322453A ES322453A1 (en) | 1965-02-01 | 1966-01-31 | Procedure for the production of indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES368113A2 true ES368113A2 (en) | 1971-06-16 |
Family
ID=56084459
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES322453A Expired ES322453A1 (en) | 1965-02-01 | 1966-01-31 | Procedure for the production of indole derivatives |
| ES368113A Expired ES368113A2 (en) | 1965-02-01 | 1969-06-07 | Procedure for the production of indole derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES322453A Expired ES322453A1 (en) | 1965-02-01 | 1966-01-31 | Procedure for the production of indole derivatives |
Country Status (1)
| Country | Link |
|---|---|
| ES (2) | ES322453A1 (en) |
-
1966
- 1966-01-31 ES ES322453A patent/ES322453A1/en not_active Expired
-
1969
- 1969-06-07 ES ES368113A patent/ES368113A2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES322453A1 (en) | 1967-03-16 |
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