ES368497A1 - Procedimiento para la preparacion de 2 - aril - amino - i- midazolinas - (2) trisustituidas. - Google Patents
Procedimiento para la preparacion de 2 - aril - amino - i- midazolinas - (2) trisustituidas.Info
- Publication number
- ES368497A1 ES368497A1 ES368497A ES368497A ES368497A1 ES 368497 A1 ES368497 A1 ES 368497A1 ES 368497 A ES368497 A ES 368497A ES 368497 A ES368497 A ES 368497A ES 368497 A1 ES368497 A1 ES 368497A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- same
- compositions containing
- imidazoline derivatives
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002462 imidazolines Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 title 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229910052801 chlorine Chemical group 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- JCOPITWIWLFFPC-UHFFFAOYSA-N n-phenyl-4,5-dihydro-1h-imidazol-2-amine Chemical class N1CCN=C1NC1=CC=CC=C1 JCOPITWIWLFFPC-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT598868A AT285599B (de) | 1968-06-21 | 1968-06-21 | Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES368497A1 true ES368497A1 (es) | 1971-05-01 |
Family
ID=3581723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES368497A Expired ES368497A1 (es) | 1968-06-21 | 1969-06-18 | Procedimiento para la preparacion de 2 - aril - amino - i- midazolinas - (2) trisustituidas. |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT285599B (de) |
| BE (1) | BE734954A (de) |
| CH (1) | CH511856A (de) |
| DE (1) | DE1929950A1 (de) |
| ES (1) | ES368497A1 (de) |
| FR (1) | FR2011408A1 (de) |
| GB (1) | GB1216945A (de) |
| IL (1) | IL32444A0 (de) |
| NL (1) | NL6909515A (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2806775A1 (de) * | 1978-02-17 | 1979-08-30 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
| DE2949287A1 (de) * | 1979-12-07 | 1981-06-11 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
| DE3168754D1 (en) * | 1980-07-09 | 1985-03-21 | Beecham Group Plc | Clonidine derivatives useful in the treatment of diarrhoea |
| US4644007A (en) * | 1981-11-20 | 1987-02-17 | Alcon Laboratories, Inc. | 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
| US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
| CA1201066A (en) * | 1981-11-20 | 1986-02-25 | Alcon Laboratories, Inc. | N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure |
| US4444782A (en) * | 1982-12-23 | 1984-04-24 | Smithkline Beckman Corporation | 2(4-tert.-Butyl-2,6-dichlorophenyl-imino)imidazolidine and use as an anti-hypertension agent |
| DE8708009U1 (de) * | 1987-06-05 | 1987-08-20 | LESCHA Maschinenfabrik GmbH, 8900 Augsburg | Vorrichtung zur Beschickung eines Mischers |
| DE19514579A1 (de) | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
-
1968
- 1968-06-21 AT AT598868A patent/AT285599B/de not_active IP Right Cessation
-
1969
- 1969-06-12 DE DE19691929950 patent/DE1929950A1/de active Pending
- 1969-06-17 CH CH923769A patent/CH511856A/de not_active IP Right Cessation
- 1969-06-18 ES ES368497A patent/ES368497A1/es not_active Expired
- 1969-06-20 FR FR6920713A patent/FR2011408A1/fr not_active Withdrawn
- 1969-06-20 NL NL6909515A patent/NL6909515A/xx unknown
- 1969-06-20 IL IL32444A patent/IL32444A0/xx unknown
- 1969-06-20 BE BE734954D patent/BE734954A/xx unknown
- 1969-06-23 GB GB31544/69A patent/GB1216945A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT285599B (de) | 1970-11-10 |
| GB1216945A (en) | 1970-12-23 |
| IL32444A0 (en) | 1969-08-27 |
| FR2011408A1 (de) | 1970-02-27 |
| BE734954A (de) | 1969-12-22 |
| DE1929950A1 (de) | 1970-03-05 |
| NL6909515A (de) | 1969-12-23 |
| CH511856A (de) | 1971-08-31 |
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