ES372061A1 - 6,9,21-trihalogenosteroids - Google Patents
6,9,21-trihalogenosteroidsInfo
- Publication number
- ES372061A1 ES372061A1 ES372061A ES372061A ES372061A1 ES 372061 A1 ES372061 A1 ES 372061A1 ES 372061 A ES372061 A ES 372061A ES 372061 A ES372061 A ES 372061A ES 372061 A1 ES372061 A1 ES 372061A1
- Authority
- ES
- Spain
- Prior art keywords
- chlorine
- formula
- known per
- manner known
- fluorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Substances 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- 239000004593 Epoxy Substances 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical group [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for the preparation of new 6,9,21-trohalogen steroids of the formula ** (see formula) ** where X means a fluorine, chlorine or bromine atom and Y means a chlorine or fluorine atom, characterized in that, in a manner known per se, to the double bond at position 9,11 of a starting steroid of the general formula ** (see formula) ** Hypohalogenic acid HOX'is added, in which X' means a chlorine or bromine atom, and -in the event that in the last desired products X means a fluorine atom- the compound 9α-chloro- or 9α-bromo is transformed -11α-hydroxy, also in a manner known per se, in 9,11-epoxide, and finally the epoxy ring is opened with hydrogen fluoride. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681801390 DE1801390C3 (en) | 1968-10-02 | 6,9,21-trihalo steroids, processes for their preparation, medicaments containing them and 6,21-dihalo intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES372061A1 true ES372061A1 (en) | 1971-09-01 |
Family
ID=5709719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES372061A Expired ES372061A1 (en) | 1968-10-02 | 1969-09-30 | 6,9,21-trihalogenosteroids |
Country Status (16)
| Country | Link |
|---|---|
| AT (1) | AT290033B (en) |
| BE (1) | BE739736A (en) |
| BR (1) | BR6912959D0 (en) |
| CH (1) | CH540891A (en) |
| CS (1) | CS150285B2 (en) |
| DK (1) | DK121053B (en) |
| ES (1) | ES372061A1 (en) |
| FI (1) | FI46505C (en) |
| FR (1) | FR2019676A1 (en) |
| GB (1) | GB1286659A (en) |
| IE (1) | IE33329B1 (en) |
| IL (1) | IL33017A (en) |
| NL (1) | NL167439C (en) |
| NO (1) | NO130824C (en) |
| RO (1) | RO54664A (en) |
| SE (1) | SE352082B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2010458B2 (en) * | 1970-02-28 | 1979-04-26 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | New 21-Halogen Steroids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3499016A (en) * | 1958-08-04 | 1970-03-03 | Upjohn Co | 6alpha-fluoro-16alpha-methyl derivatives of the pregnane series |
-
1969
- 1969-09-15 RO RO61035A patent/RO54664A/ro unknown
- 1969-09-17 IL IL33017A patent/IL33017A/en unknown
- 1969-09-22 CH CH1427369A patent/CH540891A/en not_active IP Right Cessation
- 1969-09-30 IE IE1363/69A patent/IE33329B1/en unknown
- 1969-09-30 ES ES372061A patent/ES372061A1/en not_active Expired
- 1969-09-30 GB GB48004/69A patent/GB1286659A/en not_active Expired
- 1969-10-01 CS CS6578A patent/CS150285B2/cs unknown
- 1969-10-01 FR FR6933482A patent/FR2019676A1/fr not_active Withdrawn
- 1969-10-01 NO NO3902/69A patent/NO130824C/no unknown
- 1969-10-01 SE SE13534/69A patent/SE352082B/xx unknown
- 1969-10-01 DK DK523169AA patent/DK121053B/en not_active IP Right Cessation
- 1969-10-01 AT AT928069A patent/AT290033B/en not_active IP Right Cessation
- 1969-10-02 BR BR212959/69A patent/BR6912959D0/en unknown
- 1969-10-02 BE BE739736D patent/BE739736A/xx unknown
- 1969-10-02 NL NL6914942.A patent/NL167439C/en not_active IP Right Cessation
- 1969-10-02 FI FI692843A patent/FI46505C/en active
Also Published As
| Publication number | Publication date |
|---|---|
| SE352082B (en) | 1972-12-18 |
| IE33329B1 (en) | 1974-05-29 |
| CH540891A (en) | 1973-08-31 |
| GB1286659A (en) | 1972-08-23 |
| DK121053B (en) | 1971-08-30 |
| CS150285B2 (en) | 1973-09-04 |
| BR6912959D0 (en) | 1973-02-08 |
| BE739736A (en) | 1970-04-02 |
| IE33329L (en) | 1970-04-02 |
| DE1801390A1 (en) | 1970-05-21 |
| FI46505C (en) | 1973-04-10 |
| NL167439C (en) | 1981-12-16 |
| FI46505B (en) | 1973-01-02 |
| IL33017A (en) | 1974-01-14 |
| AT290033B (en) | 1971-05-10 |
| FR2019676A1 (en) | 1970-07-03 |
| IL33017A0 (en) | 1969-11-30 |
| RO54664A (en) | 1973-03-15 |
| DE1801390B2 (en) | 1977-02-17 |
| NO130824C (en) | 1975-02-19 |
| NL167439B (en) | 1981-07-16 |
| NO130824B (en) | 1974-11-11 |
| NL6914942A (en) | 1970-04-06 |
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