ES374151A1 - PROCEDURE FOR THE PREPARATION OF NEW AMINO-PROPIOFE-NONAS. - Google Patents

PROCEDURE FOR THE PREPARATION OF NEW AMINO-PROPIOFE-NONAS.

Info

Publication number
ES374151A1
ES374151A1 ES374151A ES374151A ES374151A1 ES 374151 A1 ES374151 A1 ES 374151A1 ES 374151 A ES374151 A ES 374151A ES 374151 A ES374151 A ES 374151A ES 374151 A1 ES374151 A1 ES 374151A1
Authority
ES
Spain
Prior art keywords
beta
propiofe
nonas
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES374151A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK120969A external-priority patent/DK125242B/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES374151A1 publication Critical patent/ES374151A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

New aminopropiophenones of formula:- (where R and R' are alkyls with 3 or 4C, or R = H), esp. the beta-butyl-amino or beta-propylamino-propiohenones, are prepared from the corresponding beta-halogeno derivs. and amines RR'NH or the 4-acylamino cpds. are hydrolysed or the related secondary alcohols are oxidised or appropriately substituted acetophenones are condensed with HCHO and bases RR'NH in the presence of an acid or the amine salt. The products have better analgetic and sedative properties than previous cpds. of this type.
ES374151A 1969-03-04 1969-12-02 PROCEDURE FOR THE PREPARATION OF NEW AMINO-PROPIOFE-NONAS. Expired ES374151A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK120969A DK125242B (en) 1968-03-06 1969-03-04 Analogous process for the preparation of amino ketones.

Publications (1)

Publication Number Publication Date
ES374151A1 true ES374151A1 (en) 1971-12-16

Family

ID=8102199

Family Applications (5)

Application Number Title Priority Date Filing Date
ES374151A Expired ES374151A1 (en) 1969-03-04 1969-12-02 PROCEDURE FOR THE PREPARATION OF NEW AMINO-PROPIOFE-NONAS.
ES374323A Expired ES374323A1 (en) 1969-03-04 1969-12-06 PROCEDURE FOR THE PREPARATION OF NEW AMINO-PROPIOFE-NONAS.
ES374324A Expired ES374324A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties
ES374322A Expired ES374322A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties
ES374321A Expired ES374321A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES374323A Expired ES374323A1 (en) 1969-03-04 1969-12-06 PROCEDURE FOR THE PREPARATION OF NEW AMINO-PROPIOFE-NONAS.
ES374324A Expired ES374324A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties
ES374322A Expired ES374322A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties
ES374321A Expired ES374321A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties

Country Status (9)

Country Link
JP (1) JPS4817266B1 (en)
BG (4) BG17532A3 (en)
DE (1) DE1943777A1 (en)
ES (5) ES374151A1 (en)
HU (1) HU162685B (en)
IL (1) IL33993A (en)
NO (1) NO126617B (en)
RO (1) RO55610A (en)
SU (1) SU364160A3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0041087A1 (en) * 1980-06-03 1981-12-09 Saunders Transport Limited Wheel cleaner with powered rollers
US4906781A (en) * 1983-02-01 1990-03-06 American Cyanamid Company Method for the preparation of 4'-(substituted)-amino-2-(substituted) amino-3',5'-dichloroacetophenone and salts thereof
FR2626878B1 (en) * 1988-02-10 1990-06-08 Lafon Labor 1- (AMINOPHENYL) -2-DIMETHYLAMINOPROPANONE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE

Also Published As

Publication number Publication date
HU162685B (en) 1973-03-28
BG17534A3 (en) 1973-11-10
BG18180A3 (en) 1974-09-02
ES374322A1 (en) 1971-12-16
IL33993A0 (en) 1970-05-21
ES374323A1 (en) 1971-12-16
ES374324A1 (en) 1971-12-16
NO126617B (en) 1973-03-05
JPS4817266B1 (en) 1973-05-28
BG17533A3 (en) 1973-11-10
DE1943777A1 (en) 1970-09-24
RO55610A (en) 1973-09-20
ES374321A1 (en) 1971-12-16
BG17532A3 (en) 1973-11-10
IL33993A (en) 1973-08-29
SU364160A3 (en) 1972-12-25

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