ES377329A1 - Improvements in or relating to cephalosporin compounds - Google Patents
Improvements in or relating to cephalosporin compoundsInfo
- Publication number
- ES377329A1 ES377329A1 ES377329A ES377329A ES377329A1 ES 377329 A1 ES377329 A1 ES 377329A1 ES 377329 A ES377329 A ES 377329A ES 377329 A ES377329 A ES 377329A ES 377329 A1 ES377329 A1 ES 377329A1
- Authority
- ES
- Spain
- Prior art keywords
- acid
- boiling
- esters
- oxide
- relating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- -1 cephalosporin compounds Chemical class 0.000 title 1
- 238000009835 boiling Methods 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/08—Preparation by forming the ring or condensed ring systems
- C07D501/10—Preparation by forming the ring or condensed ring systems from compounds containing the penicillin ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A process for preparing 7beta-acylamido-3-methyl cef-3-em-4-carboxylic acid esters, comprising redistributing a 6beta-acylamidopenicillinic acid 1-oxide ester (hereinafter called penicillin oxide) in the presence of an acid catalyst which it is a hydrocarbon sulfonic acid or a phosphorous acid, and of a solvent chosen from ketones boiling at 75 to 120ºC, esters boiling at 75 to 140ºC, dioxane (in which solvents the reaction is carried out for a time at least 2 hours at a temperature of 75 to 110ºC, and for at least 45 min at higher temperatures), and diethylene glycol dimethyl ether. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB02865/69A GB1299734A (en) | 1969-03-11 | 1969-03-11 | Improvements in or relating to cephalosporin compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES377329A1 true ES377329A1 (en) | 1972-06-16 |
Family
ID=10012562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES377329A Expired ES377329A1 (en) | 1969-03-11 | 1970-03-10 | Improvements in or relating to cephalosporin compounds |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5417751B1 (en) |
| AT (1) | AT306920B (en) |
| BE (1) | BE747118A (en) |
| BR (1) | BR6915236D0 (en) |
| CH (1) | CH537416A (en) |
| DE (1) | DE2011375A1 (en) |
| ES (1) | ES377329A1 (en) |
| FR (1) | FR2037857A5 (en) |
| GB (1) | GB1299734A (en) |
| HU (1) | HU165811B (en) |
| IE (1) | IE34074B1 (en) |
| NL (1) | NL7003357A (en) |
| SE (1) | SE386901B (en) |
| YU (1) | YU36378B (en) |
| ZA (1) | ZA701626B (en) |
-
1969
- 1969-03-11 GB GB02865/69A patent/GB1299734A/en not_active Expired
- 1969-12-16 BR BR215236/69A patent/BR6915236D0/en unknown
-
1970
- 1970-03-10 NL NL7003357A patent/NL7003357A/xx unknown
- 1970-03-10 BE BE747118D patent/BE747118A/en not_active IP Right Cessation
- 1970-03-10 DE DE19702011375 patent/DE2011375A1/en active Pending
- 1970-03-10 ZA ZA701626A patent/ZA701626B/en unknown
- 1970-03-10 ES ES377329A patent/ES377329A1/en not_active Expired
- 1970-03-10 JP JP2002470A patent/JPS5417751B1/ja active Pending
- 1970-03-10 HU HUGA999A patent/HU165811B/hu unknown
- 1970-03-10 AT AT225270A patent/AT306920B/en not_active IP Right Cessation
- 1970-03-10 SE SE7003188A patent/SE386901B/en unknown
- 1970-03-10 CH CH355370A patent/CH537416A/en not_active IP Right Cessation
- 1970-03-10 FR FR7008449A patent/FR2037857A5/fr not_active Expired
- 1970-03-10 IE IE316/70A patent/IE34074B1/en unknown
- 1970-03-11 YU YU00580/70A patent/YU36378B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2037857A5 (en) | 1970-12-31 |
| NL7003357A (en) | 1970-09-15 |
| CH537416A (en) | 1973-05-31 |
| AT306920B (en) | 1973-04-25 |
| DE2011375A1 (en) | 1970-09-24 |
| YU36378B (en) | 1983-06-30 |
| HU165811B (en) | 1974-11-28 |
| IE34074L (en) | 1970-09-11 |
| SE386901B (en) | 1976-08-23 |
| YU58070A (en) | 1981-11-13 |
| ZA701626B (en) | 1971-10-27 |
| JPS5417751B1 (en) | 1979-07-02 |
| BE747118A (en) | 1970-09-10 |
| BR6915236D0 (en) | 1973-02-13 |
| GB1299734A (en) | 1972-12-13 |
| IE34074B1 (en) | 1975-01-22 |
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