ES377444A1 - Procedure for preparation of new eteres of 2-hydroxyzenzamide. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for preparation of new eteres of 2-hydroxyzenzamide. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES377444A1 ES377444A1 ES377444A ES377444A ES377444A1 ES 377444 A1 ES377444 A1 ES 377444A1 ES 377444 A ES377444 A ES 377444A ES 377444 A ES377444 A ES 377444A ES 377444 A1 ES377444 A1 ES 377444A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- procedure
- machine
- legally binding
- google translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- -1 2-hydroxy-benzamide ethers Chemical class 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- 229960000581 salicylamide Drugs 0.000 abstract 2
- 150000003385 sodium Chemical class 0.000 abstract 2
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical compound NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for preparing new 2-hydroxy-benzamide ethers, corresponding to the formula **(See formula)** which R is chosen from the group consisting of radicals: -CH2C6H5, -CH2-C6H4C1 (para), -CH2-CH2C1, -CH2-CH2Cl- (N) -piperidyl, -CH2-CH.OH-CH2OH, - (CH2) 3-SO2-C6H5, - (CH2) 5-O-C6H4-CONH (ortho), - (CH2) 8-CH3, - (CH2) 10) -CH3 characterized in that the sodium derivative of the phenol function of salicylamide is formed by reaction with sodium ethylate, then it is reacts this sodium derivative with a halide of the formula Hal.R, in which Hal represents a halide and E has the meaning indicated above, in ethyl medium, at a temperature less than or equal to the boiling temperature of ethanol, and then it is they remove the sodium halides formed as well as, optionally, all or part of the ethanol, and the ethers formed are crystallized from appropriate solvents. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR6906209A FR2035764A1 (en) | 1969-03-06 | 1969-03-06 | Salicylamide ethers with analgesic, anti- - inflammatory and cns-sedative activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES377444A1 true ES377444A1 (en) | 1972-07-01 |
Family
ID=9030193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES377444A Expired ES377444A1 (en) | 1969-03-06 | 1970-03-03 | Procedure for preparation of new eteres of 2-hydroxyzenzamide. (Machine-translation by Google Translate, not legally binding) |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE746940A (en) |
| CH (1) | CH511805A (en) |
| DE (1) | DE2010222B2 (en) |
| ES (1) | ES377444A1 (en) |
| FR (1) | FR2035764A1 (en) |
| NL (1) | NL7003194A (en) |
| OA (1) | OA03444A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4436127A1 (en) * | 1994-09-27 | 1996-03-28 | Deutsches Rheumaforschungszent | Use of benzoic or pyridine:carboxylic acid or amide cpds. |
-
1969
- 1969-03-06 FR FR6906209A patent/FR2035764A1/en not_active Withdrawn
-
1970
- 1970-03-03 ES ES377444A patent/ES377444A1/en not_active Expired
- 1970-03-04 OA OA53865A patent/OA03444A/en unknown
- 1970-03-04 CH CH318570A patent/CH511805A/en not_active IP Right Cessation
- 1970-03-04 DE DE2010222A patent/DE2010222B2/en active Granted
- 1970-03-05 NL NL7003194A patent/NL7003194A/xx unknown
- 1970-03-06 BE BE746940D patent/BE746940A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| OA03444A (en) | 1971-03-30 |
| NL7003194A (en) | 1970-09-08 |
| DE2010222A1 (en) | 1970-10-01 |
| FR2035764A1 (en) | 1970-12-24 |
| DE2010222B2 (en) | 1975-07-17 |
| CH511805A (en) | 1971-08-31 |
| BE746940A (en) | 1970-08-17 |
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