ES378917A1 - Metodo para preparar una amida formacodinamicamente activa. - Google Patents
Metodo para preparar una amida formacodinamicamente activa.Info
- Publication number
- ES378917A1 ES378917A1 ES378917A ES378917A ES378917A1 ES 378917 A1 ES378917 A1 ES 378917A1 ES 378917 A ES378917 A ES 378917A ES 378917 A ES378917 A ES 378917A ES 378917 A1 ES378917 A1 ES 378917A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- reacting
- ethyl
- compounds
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CSNIZNHTOVFARY-UHFFFAOYSA-N 1,2-benzothiazole Chemical class C1=CC=C2C=NSC2=C1 CSNIZNHTOVFARY-UHFFFAOYSA-N 0.000 title abstract 3
- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical compound C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 7
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- HWLOCGLMEHUBAQ-UHFFFAOYSA-N 2-(1,2-benzothiazol-3-yl)acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=NSC2=C1 HWLOCGLMEHUBAQ-UHFFFAOYSA-N 0.000 abstract 1
- IYNFJKUJHGHOJF-UHFFFAOYSA-N 2-(3-oxo-1H-isoindol-2-yl)acetyl chloride Chemical compound O=C1N(CC2=CC=CC=C12)CC(=O)Cl IYNFJKUJHGHOJF-UHFFFAOYSA-N 0.000 abstract 1
- ZRWICZHXYMHBDP-UHFFFAOYSA-N 2-chlorosulfonylbenzoic acid Chemical compound OC(=O)C1=CC=CC=C1S(Cl)(=O)=O ZRWICZHXYMHBDP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- YKCQHUPTHHPHGX-UHFFFAOYSA-N ethyl 2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetate Chemical compound C1=CC=C2S(=O)(=O)N(CC(=O)OCC)C(=O)C2=C1 YKCQHUPTHHPHGX-UHFFFAOYSA-N 0.000 abstract 1
- 125000005067 haloformyl group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical compound C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE05806/69A SE333734B (es) | 1969-04-23 | 1969-04-23 | |
| SE07055/69A SE361667B (es) | 1969-05-20 | 1969-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES378917A1 true ES378917A1 (es) | 1973-01-16 |
Family
ID=26654657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES378917A Expired ES378917A1 (es) | 1969-04-23 | 1970-04-22 | Metodo para preparar una amida formacodinamicamente activa. |
Country Status (8)
| Country | Link |
|---|---|
| AU (1) | AU1404370A (es) |
| BE (1) | BE749416A (es) |
| DE (1) | DE2019476A1 (es) |
| DK (1) | DK124953B (es) |
| ES (1) | ES378917A1 (es) |
| FR (1) | FR2042365A1 (es) |
| GB (1) | GB1271054A (es) |
| IL (1) | IL34317A0 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7907121L (sv) | 1979-08-27 | 1981-02-28 | Astra Laekemedel Ab | Ftalimidinderivat |
| JPS6169773A (ja) * | 1984-09-14 | 1986-04-10 | Takeda Chem Ind Ltd | イソインドリノン誘導体 |
| EP2344479B1 (en) * | 2008-09-23 | 2015-04-08 | Georgetown University | 1,2-benzisothiazolinone and isoindolinone derivatives |
| CA2845551C (en) | 2011-08-16 | 2020-06-09 | Georgetown University | Methods of treating bacterial infections with 1,2-benzisothiazolinone and isoindolinone derivatives |
-
1970
- 1970-04-14 IL IL34317A patent/IL34317A0/xx unknown
- 1970-04-17 AU AU14043/70A patent/AU1404370A/en not_active Expired
- 1970-04-22 ES ES378917A patent/ES378917A1/es not_active Expired
- 1970-04-22 GB GB09363/70A patent/GB1271054A/en not_active Expired
- 1970-04-22 DK DK202670AA patent/DK124953B/da unknown
- 1970-04-22 DE DE19702019476 patent/DE2019476A1/de active Pending
- 1970-04-23 FR FR7014786A patent/FR2042365A1/fr not_active Withdrawn
- 1970-04-23 BE BE749416D patent/BE749416A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL34317A0 (en) | 1970-06-17 |
| BE749416A (fr) | 1970-10-01 |
| AU1404370A (en) | 1971-10-21 |
| FR2042365A1 (es) | 1971-02-12 |
| GB1271054A (en) | 1972-04-19 |
| DK124953B (da) | 1972-12-11 |
| DE2019476A1 (de) | 1970-12-03 |
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