ES384814A1 - A procedure for preparing benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for preparing benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES384814A1 ES384814A1 ES384814A ES384814A ES384814A1 ES 384814 A1 ES384814 A1 ES 384814A1 ES 384814 A ES384814 A ES 384814A ES 384814 A ES384814 A ES 384814A ES 384814 A1 ES384814 A1 ES 384814A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- procedure
- machine
- legally binding
- google translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title abstract 2
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- IEGKHNXXLDCDTE-UHFFFAOYSA-N 1,2-benzodiazepin-2-amine Chemical class NN1C=CC=C2C=CC=CC2=N1 IEGKHNXXLDCDTE-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A procedure for preparing benzodiazepine derivatives of the general formula **(See formula)** (where R1 hydrogen or a hydrocarbon radical, R2 is hydrogen or lower alcohol, the respective rings A and B are substituted or unsubstituted by one or more nitro, trifluoromethyl, halogen, alcohol or alkoxy groups, and the nitrogen atom in the position 5 may be in the form of N-oxide), characterized in that it comprises reacting 2-aminobenzodiazepine derivatives of the general formula **(See formula)** (Where all symbols have the same meanings as above and the 4-position nitrogen atom may be in the N-oxide form) with acylhydrazines of the general formula NH2NHCOR1 (where R1 has the same meaning as above), followed by subjecting the resulting product to a ring closure reaction. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8487069A JPS4927880B1 (en) | 1969-10-23 | 1969-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES384814A1 true ES384814A1 (en) | 1973-09-01 |
Family
ID=13842822
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES384814A Expired ES384814A1 (en) | 1969-10-23 | 1970-10-22 | A procedure for preparing benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES413244A Expired ES413244A1 (en) | 1969-10-23 | 1973-03-31 | A procedure for preparing benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES413244A Expired ES413244A1 (en) | 1969-10-23 | 1973-03-31 | A procedure for preparing benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4927880B1 (en) |
| AT (1) | AT299958B (en) |
| CH (1) | CH550810A (en) |
| DK (1) | DK141726B (en) |
| ES (2) | ES384814A1 (en) |
| FI (1) | FI51699C (en) |
| NL (1) | NL7015430A (en) |
| SE (1) | SE383348B (en) |
| YU (1) | YU34881B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3879406A (en) * | 1972-07-13 | 1975-04-22 | Hoffmann La Roche | Preparation of triazolobenzodiazepines |
| US4155913A (en) * | 1973-02-08 | 1979-05-22 | Hoffmann-La Roche Inc. | Thienotriazolodiazepine derivatives |
-
1969
- 1969-10-23 JP JP8487069A patent/JPS4927880B1/ja active Pending
-
1970
- 1970-10-14 DK DK520370A patent/DK141726B/en not_active IP Right Cessation
- 1970-10-21 NL NL7015430A patent/NL7015430A/xx unknown
- 1970-10-21 YU YU257470A patent/YU34881B/en unknown
- 1970-10-22 FI FI285070A patent/FI51699C/en active
- 1970-10-22 SE SE1428570A patent/SE383348B/en unknown
- 1970-10-22 ES ES384814A patent/ES384814A1/en not_active Expired
- 1970-10-23 AT AT957570A patent/AT299958B/en not_active IP Right Cessation
- 1970-10-23 CH CH1571270A patent/CH550810A/en not_active IP Right Cessation
-
1973
- 1973-03-31 ES ES413244A patent/ES413244A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH550810A (en) | 1974-06-28 |
| FI51699C (en) | 1977-03-10 |
| DK141726C (en) | 1980-10-27 |
| SE383348B (en) | 1976-03-08 |
| ES413244A1 (en) | 1976-01-01 |
| DK141726B (en) | 1980-06-02 |
| JPS4927880B1 (en) | 1974-07-22 |
| FI51699B (en) | 1976-11-30 |
| YU257470A (en) | 1979-10-31 |
| YU34881B (en) | 1980-04-30 |
| AT299958B (en) | 1972-07-10 |
| NL7015430A (en) | 1971-04-27 |
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