ES386601A1 - Un procedimiento de resolucion de 2-(oclorofenil) - 2- me- tilamino-ciclohexanona racemica. - Google Patents
Un procedimiento de resolucion de 2-(oclorofenil) - 2- me- tilamino-ciclohexanona racemica.Info
- Publication number
- ES386601A1 ES386601A1 ES386601A ES386601A ES386601A1 ES 386601 A1 ES386601 A1 ES 386601A1 ES 386601 A ES386601 A ES 386601A ES 386601 A ES386601 A ES 386601A ES 386601 A1 ES386601 A1 ES 386601A1
- Authority
- ES
- Spain
- Prior art keywords
- methylaminocyclohexanone
- chlorophenyl
- tartaric acid
- isomer
- racemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 title abstract 6
- 229960003299 ketamine Drugs 0.000 title 1
- 150000003892 tartrate salts Chemical class 0.000 abstract 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88679969A | 1969-12-19 | 1969-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES386601A1 true ES386601A1 (es) | 1974-01-16 |
Family
ID=25389797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES386601A Expired ES386601A1 (es) | 1969-12-19 | 1970-12-18 | Un procedimiento de resolucion de 2-(oclorofenil) - 2- me- tilamino-ciclohexanona racemica. |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4948542B1 (de) |
| BE (1) | BE760492A (de) |
| CH (1) | CH535201A (de) |
| DE (1) | DE2062620A1 (de) |
| ES (1) | ES386601A1 (de) |
| FR (1) | FR2081388B1 (de) |
| GB (1) | GB1330878A (de) |
| NL (1) | NL7018334A (de) |
| ZA (1) | ZA708468B (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5875614A (ja) * | 1981-10-28 | 1983-05-07 | Matsushita Electric Ind Co Ltd | 焼却炉の排ガス浄化装置 |
| DE4312016A1 (de) * | 1993-04-13 | 1994-10-20 | Goedecke Ag | Stabile Ketamin-Lösungen |
| DE19619665C2 (de) * | 1996-05-15 | 2001-03-08 | Goedecke Ag | Racemattrennung von Ketamin |
| BRPI0002693B8 (pt) * | 2000-06-19 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | processo de obtenção dos enantiômeros da cetamina e seus sais farmaceuticamente aceitáveis |
| US7273889B2 (en) * | 2002-09-25 | 2007-09-25 | Innovative Drug Delivery Systems, Inc. | NMDA receptor antagonist formulation with reduced neurotoxicity |
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| KR101271263B1 (ko) | 2005-09-28 | 2013-06-07 | 아우리스 메디칼 아게 | 내이 장애 치료용 약학 조성물 |
| WO2013087090A1 (en) | 2011-12-12 | 2013-06-20 | Auris Medical Ag | Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system |
| US20140274981A1 (en) | 2013-03-15 | 2014-09-18 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| HUE056378T2 (hu) | 2013-09-13 | 2022-02-28 | Univ Chiba Nat Univ Corp | R-Ketamin és sójának alkalmazása gyógyszerekként |
| KR20170040800A (ko) | 2014-08-13 | 2017-04-13 | 얀센 파마슈티카 엔.브이. | 우울증 치료 방법 |
| AU2015318123A1 (en) | 2014-09-15 | 2017-03-30 | Janssen Pharmaceutica Nv | Val66Met (SNP rs6265) genotype specific dosing regimens and methods for the treatment of depression |
| US20160332962A1 (en) | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| KR20240011237A (ko) | 2017-12-22 | 2024-01-25 | 얀센 파마슈티카 엔브이 | 우울증 치료를 위한 에스케타민 |
| US11980595B2 (en) | 2018-02-15 | 2024-05-14 | National University Corporation Chiba University | Preventive or therapeutic agent and pharmaceutical composition for inflammatory diseases or bone diseases |
| CN110218157B (zh) * | 2018-03-01 | 2022-08-23 | 江苏恒瑞医药股份有限公司 | 一种r-氯胺酮及其可药用盐的制备方法 |
| WO2019213551A1 (en) | 2018-05-04 | 2019-11-07 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
| BR112020023882A2 (pt) | 2018-06-27 | 2021-02-09 | Clexio Biosciences Ltd. | método para tratar transtorno depressivo maior |
| CN112702995A (zh) | 2018-10-05 | 2021-04-23 | 克雷西奥生物科技有限公司 | 治疗重度抑郁症的艾氯胺酮的治疗方案 |
| WO2020070547A1 (en) | 2018-10-05 | 2020-04-09 | Clexio Biosciences Ltd. | Dosage regime of esketamine for treating major depressive disorder |
| EP3863617A1 (de) | 2018-10-11 | 2021-08-18 | Clexio Biosciences Ltd. | Esketamin zur verwendung bei der behandlung einer schweren depressiven störung |
| JP2022524008A (ja) | 2019-03-05 | 2022-04-27 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | うつ病の治療のためのエスケタミン |
| WO2021137148A1 (en) | 2019-12-30 | 2021-07-08 | Clexio Biosciences Ltd. | Dosage regime with esketamine for treating neuropsychiatric or neurological conditions |
| EP4084786A1 (de) | 2019-12-30 | 2022-11-09 | Clexio Biosciences Ltd. | Dosierungsschema mit esketamin zur behandlung einer schweren depressiven störung |
| JP2023507926A (ja) | 2019-12-30 | 2023-02-28 | クレキシオ バイオサイエンシーズ エルティーディー． | 神経精神状態または神経学的状態を治療するためのエスケタミンを用いた投与計画 |
| JP2023511370A (ja) | 2020-01-22 | 2023-03-17 | シーロス セラピューティクス， インコーポレイテッド | Ｎｍｄａ拮抗薬の副作用の低減 |
| CN112125816A (zh) * | 2020-03-17 | 2020-12-25 | 国药集团工业有限公司 | 一种氯胺酮、其衍生物或其盐的消旋化方法 |
| WO2025057111A1 (en) | 2023-09-12 | 2025-03-20 | Clexio Biosciences Ltd. | Esketamine or a pharmaceutical salt thereof for use in a method of treating major depressive disorder |
-
1970
- 1970-12-11 CH CH1836870A patent/CH535201A/de not_active IP Right Cessation
- 1970-12-15 ZA ZA708468A patent/ZA708468B/xx unknown
- 1970-12-16 NL NL7018334A patent/NL7018334A/xx unknown
- 1970-12-17 BE BE760492A patent/BE760492A/xx unknown
- 1970-12-18 GB GB6017370A patent/GB1330878A/en not_active Expired
- 1970-12-18 ES ES386601A patent/ES386601A1/es not_active Expired
- 1970-12-18 DE DE19702062620 patent/DE2062620A1/de active Pending
- 1970-12-18 FR FR7045893A patent/FR2081388B1/fr not_active Expired
- 1970-12-19 JP JP11363170A patent/JPS4948542B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2081388A1 (de) | 1971-12-03 |
| JPS4948542B1 (de) | 1974-12-21 |
| ZA708468B (en) | 1972-02-23 |
| GB1330878A (en) | 1973-09-19 |
| FR2081388B1 (de) | 1974-06-21 |
| BE760492A (fr) | 1971-06-17 |
| CH535201A (de) | 1973-03-31 |
| DE2062620A1 (de) | 1971-07-15 |
| NL7018334A (de) | 1971-06-22 |
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