ES386601A1 - Un procedimiento de resolucion de 2-(oclorofenil) - 2- me- tilamino-ciclohexanona racemica. - Google Patents
Un procedimiento de resolucion de 2-(oclorofenil) - 2- me- tilamino-ciclohexanona racemica.Info
- Publication number
- ES386601A1 ES386601A1 ES386601A ES386601A ES386601A1 ES 386601 A1 ES386601 A1 ES 386601A1 ES 386601 A ES386601 A ES 386601A ES 386601 A ES386601 A ES 386601A ES 386601 A1 ES386601 A1 ES 386601A1
- Authority
- ES
- Spain
- Prior art keywords
- methylaminocyclohexanone
- chlorophenyl
- tartaric acid
- isomer
- racemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 title abstract 6
- 229960003299 ketamine Drugs 0.000 title 1
- 150000003892 tartrate salts Chemical class 0.000 abstract 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88679969A | 1969-12-19 | 1969-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES386601A1 true ES386601A1 (es) | 1974-01-16 |
Family
ID=25389797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES386601A Expired ES386601A1 (es) | 1969-12-19 | 1970-12-18 | Un procedimiento de resolucion de 2-(oclorofenil) - 2- me- tilamino-ciclohexanona racemica. |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4948542B1 (de) |
| BE (1) | BE760492A (de) |
| CH (1) | CH535201A (de) |
| DE (1) | DE2062620A1 (de) |
| ES (1) | ES386601A1 (de) |
| FR (1) | FR2081388B1 (de) |
| GB (1) | GB1330878A (de) |
| NL (1) | NL7018334A (de) |
| ZA (1) | ZA708468B (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5875614A (ja) * | 1981-10-28 | 1983-05-07 | Matsushita Electric Ind Co Ltd | 焼却炉の排ガス浄化装置 |
| DE4312016A1 (de) * | 1993-04-13 | 1994-10-20 | Goedecke Ag | Stabile Ketamin-Lösungen |
| DE19619665C2 (de) * | 1996-05-15 | 2001-03-08 | Goedecke Ag | Racemattrennung von Ketamin |
| BRPI0002693B8 (pt) * | 2000-06-19 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | processo de obtenção dos enantiômeros da cetamina e seus sais farmaceuticamente aceitáveis |
| US7273889B2 (en) | 2002-09-25 | 2007-09-25 | Innovative Drug Delivery Systems, Inc. | NMDA receptor antagonist formulation with reduced neurotoxicity |
| US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| PT1928405E (pt) | 2005-09-28 | 2014-10-20 | Auris Medical Ag | Composições farmacêuticas para o tratamento de distúrbios do ouvido interno |
| WO2013087090A1 (en) | 2011-12-12 | 2013-06-20 | Auris Medical Ag | Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system |
| US20140275278A1 (en) | 2013-03-15 | 2014-09-18 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| HRP20211629T1 (hr) | 2013-09-13 | 2022-02-04 | National University Corporation Chiba University | Primjena r-ketamina i njegove soli kao lijekova |
| EP3179993B1 (de) | 2014-08-13 | 2021-01-20 | Janssen Pharmaceutica NV | Esketamine zur verwendung in einem verfahren zur behandlung von depression |
| CA2961208A1 (en) | 2014-09-15 | 2016-03-24 | Janssen Pharmaceutica Nv | Val66met (snp rs6265) genotype specific dosing regimens and methods for the treatment of depression |
| US20160332962A1 (en) * | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| MX2020006650A (es) | 2017-12-22 | 2020-11-06 | Janssen Pharmaceuticals Inc | Esketamina para el tratamiento de la depresión. |
| CN118453559A (zh) | 2018-02-15 | 2024-08-09 | 国立大学法人千叶大学 | 炎症性疾病或骨病的预防或治疗剂及医药组合物 |
| CN110218157B (zh) * | 2018-03-01 | 2022-08-23 | 江苏恒瑞医药股份有限公司 | 一种r-氯胺酮及其可药用盐的制备方法 |
| CA3099293A1 (en) | 2018-05-04 | 2019-11-07 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
| BR112020023882A2 (pt) | 2018-06-27 | 2021-02-09 | Clexio Biosciences Ltd. | método para tratar transtorno depressivo maior |
| WO2020070547A1 (en) | 2018-10-05 | 2020-04-09 | Clexio Biosciences Ltd. | Dosage regime of esketamine for treating major depressive disorder |
| US11865088B2 (en) | 2018-10-05 | 2024-01-09 | Clexio Biosciences Ltd. | Method of treating major depressive disorder |
| EP3863617A1 (de) | 2018-10-11 | 2021-08-18 | Clexio Biosciences Ltd. | Esketamin zur verwendung bei der behandlung einer schweren depressiven störung |
| WO2020178653A1 (en) | 2019-03-05 | 2020-09-10 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| WO2021137148A1 (en) | 2019-12-30 | 2021-07-08 | Clexio Biosciences Ltd. | Dosage regime with esketamine for treating neuropsychiatric or neurological conditions |
| US12268658B2 (en) | 2019-12-30 | 2025-04-08 | Clexio Biosciences Ltd. | Dosage regime with esketamine for treating major depressive disorder |
| US12478592B2 (en) | 2019-12-30 | 2025-11-25 | Clexio Biosciences Ltd. | Dosage regime with esketamine for treating neuropsychiatric or neurological conditions |
| PH12022551856A1 (en) | 2020-01-22 | 2024-01-03 | Seelos Therapeutics Inc | Reducing side effects of nmda antagonists |
| CN112125816A (zh) * | 2020-03-17 | 2020-12-25 | 国药集团工业有限公司 | 一种氯胺酮、其衍生物或其盐的消旋化方法 |
| WO2025057111A1 (en) | 2023-09-12 | 2025-03-20 | Clexio Biosciences Ltd. | Esketamine or a pharmaceutical salt thereof for use in a method of treating major depressive disorder |
-
1970
- 1970-12-11 CH CH1836870A patent/CH535201A/de not_active IP Right Cessation
- 1970-12-15 ZA ZA708468A patent/ZA708468B/xx unknown
- 1970-12-16 NL NL7018334A patent/NL7018334A/xx unknown
- 1970-12-17 BE BE760492A patent/BE760492A/xx unknown
- 1970-12-18 GB GB6017370A patent/GB1330878A/en not_active Expired
- 1970-12-18 FR FR7045893A patent/FR2081388B1/fr not_active Expired
- 1970-12-18 ES ES386601A patent/ES386601A1/es not_active Expired
- 1970-12-18 DE DE19702062620 patent/DE2062620A1/de active Pending
- 1970-12-19 JP JP11363170A patent/JPS4948542B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL7018334A (de) | 1971-06-22 |
| FR2081388B1 (de) | 1974-06-21 |
| ZA708468B (en) | 1972-02-23 |
| DE2062620A1 (de) | 1971-07-15 |
| GB1330878A (en) | 1973-09-19 |
| FR2081388A1 (de) | 1971-12-03 |
| BE760492A (fr) | 1971-06-17 |
| CH535201A (de) | 1973-03-31 |
| JPS4948542B1 (de) | 1974-12-21 |
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