ES389253A1 - A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF PROPIONIC ACID2- (4- (2-FLUOROPHENOXY) PHENYL). - Google Patents

A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF PROPIONIC ACID2- (4- (2-FLUOROPHENOXY) PHENYL).

Info

Publication number
ES389253A1
ES389253A1 ES389253A ES389253A ES389253A1 ES 389253 A1 ES389253 A1 ES 389253A1 ES 389253 A ES389253 A ES 389253A ES 389253 A ES389253 A ES 389253A ES 389253 A1 ES389253 A1 ES 389253A1
Authority
ES
Spain
Prior art keywords
free acid
procedure
preparation
fluorophenoxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES389253A
Other languages
Spanish (es)
Inventor
S Adams
J Tantum
B Armitage
J Nicholson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Pure Drug Co Ltd
Original Assignee
Boots Pure Drug Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Pure Drug Co Ltd filed Critical Boots Pure Drug Co Ltd
Publication of ES389253A1 publication Critical patent/ES389253A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A procedure for the preparation of a compound of the general formula I ** (See formula) ** wherein Y is COOH, CONH2 or CH2OH, together with pharmaceutically acceptable esters, inorganic salts and organic salts of those compounds in which Y is COOH, characterized by hydrolyzing a compound of the general formula II ** (See formula) ** wherein Z is cyano, carbamoyl, or COOR4, where R4 is an ester forming group, and, if desired, (a) a free acid thus obtained is esterified to provide an ester, (b) a free acid thus obtained it is amidated to provide an amide, (c) a free acid thus obtained is reduced to provide an alcohol or (d) a free acid thus obtained is transformed into a pharmaceutically acceptable salt. (Machine-translation by Google Translate, not legally binding)
ES389253A 1970-03-16 1971-03-15 A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF PROPIONIC ACID2- (4- (2-FLUOROPHENOXY) PHENYL). Expired ES389253A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1257070 1970-03-16

Publications (1)

Publication Number Publication Date
ES389253A1 true ES389253A1 (en) 1973-06-16

Family

ID=10007088

Family Applications (4)

Application Number Title Priority Date Filing Date
ES389253A Expired ES389253A1 (en) 1970-03-16 1971-03-15 A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF PROPIONIC ACID2- (4- (2-FLUOROPHENOXY) PHENYL).
ES389252A Expired ES389252A1 (en) 1970-03-16 1971-03-15 PROCEDURE FOR THE PREPARATION OF PROPIONIC ACIDS SUBSTITUTED BY PHENYL IN POSITION 2.
ES398802A Expired ES398802A1 (en) 1970-03-16 1972-01-12 PROCEDURE FOR THE PREPARATION OF PROPIONIC ACIDS SUBSTITUTED BY PHENYL IN POSITION 2.
ES398803A Expired ES398803A1 (en) 1970-03-16 1972-01-12 A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 2- (4- (2-FLUOROPHENOXY) PHENYL) PROPIONIC ACID.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES389252A Expired ES389252A1 (en) 1970-03-16 1971-03-15 PROCEDURE FOR THE PREPARATION OF PROPIONIC ACIDS SUBSTITUTED BY PHENYL IN POSITION 2.
ES398802A Expired ES398802A1 (en) 1970-03-16 1972-01-12 PROCEDURE FOR THE PREPARATION OF PROPIONIC ACIDS SUBSTITUTED BY PHENYL IN POSITION 2.
ES398803A Expired ES398803A1 (en) 1970-03-16 1972-01-12 A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 2- (4- (2-FLUOROPHENOXY) PHENYL) PROPIONIC ACID.

Country Status (18)

Country Link
AT (4) AT318574B (en)
BE (2) BE764258A (en)
CA (2) CA925878A (en)
CH (2) CH530363A (en)
CS (4) CS169813B2 (en)
DE (2) DE2112323A1 (en)
DK (1) DK139673B (en)
ES (4) ES389253A1 (en)
FR (2) FR2085713B1 (en)
GB (1) GB1307284A (en)
IE (2) IE35234B1 (en)
IL (2) IL36395A (en)
NL (2) NL7103404A (en)
NO (2) NO131507C (en)
PL (4) PL94402B1 (en)
RO (4) RO61058A (en)
SE (2) SE366733B (en)
ZA (2) ZA711644B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2837525A1 (en) * 1978-08-28 1980-03-20 Bayer Ag PROCESS FOR THE PRODUCTION OF 4-FLUORO-3-PHENOXY-TOLUENE
SE8400239D0 (en) * 1984-01-19 1984-01-19 Pharmacia Ab NEW ARYLETIC ACID DERIVATIVES
AU611255B2 (en) * 1987-12-28 1991-06-06 Dowelanco Phenoxyphenoxypropionates, intermediates thereof and methods of preparation
ES2163986B1 (en) * 1999-07-13 2003-02-16 Menarini Lab ACIDOS-ALFA-ARILPROPIONICOS AND ARILACETICOS AS INHIBITORS OF CYCLLOXYGENASA-II.
FR2862964B1 (en) * 2003-11-27 2006-12-29 Merck Sante Sas DERIVATIVES OF DIPHENYLAMINE.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE363818B (en) * 1968-08-15 1974-02-04 Lilly Co Eli

Also Published As

Publication number Publication date
ES398802A1 (en) 1974-08-16
CS169813B2 (en) 1976-07-29
BE764258A (en) 1971-09-15
RO61093A (en) 1976-08-15
DK139673C (en) 1979-09-10
FR2085713B1 (en) 1974-08-23
IL36395A0 (en) 1971-05-26
SE366732B (en) 1974-05-06
CA925878A (en) 1973-05-08
CA925520A (en) 1973-05-01
RO61058A (en) 1976-08-15
NL7103404A (en) 1971-09-20
IL36394A (en) 1974-11-29
RO62254A (en) 1977-08-15
AT318575B (en) 1974-10-25
NO132989B (en) 1975-11-10
ES389252A1 (en) 1974-04-16
NL7103403A (en) 1971-09-20
IE35234B1 (en) 1975-12-24
IE35109L (en) 1971-09-16
RO61065A (en) 1976-08-15
NO131507B (en) 1975-03-03
CH530363A (en) 1972-11-15
FR2085713A1 (en) 1971-12-31
AT318577B (en) 1974-10-25
AT318576B (en) 1974-10-25
DE2112323A1 (en) 1971-11-25
FR2085712B1 (en) 1974-09-27
IL36394A0 (en) 1971-05-26
PL72430B1 (en) 1974-06-29
NO131507C (en) 1975-06-11
ZA711644B (en) 1971-12-29
IE35234L (en) 1971-09-16
FR2085712A1 (en) 1971-12-31
DK139673B (en) 1979-03-26
ES398803A1 (en) 1974-08-16
IE35109B1 (en) 1975-11-12
CH532010A (en) 1972-12-31
PL94403B1 (en) 1977-08-31
PL70292B1 (en) 1974-02-28
AT318574B (en) 1974-10-25
CS170542B2 (en) 1976-08-27
NO132989C (en) 1976-02-18
PL94402B1 (en) 1977-08-31
DE2112322A1 (en) 1971-10-14
GB1307284A (en) 1973-02-14
ZA711643B (en) 1971-12-29
SE366733B (en) 1974-05-06
BE764257A (en) 1971-09-15
CS170543B2 (en) 1976-08-27
CS169814B2 (en) 1976-07-29
IL36395A (en) 1975-02-10

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