ES390456A1 - PROCEDURE FOR OBTAINING 13-ALKYL-17 BETA-HIDRO-XI-17 ALPHA-PROPADIENYLGONE-4, 9 (10), 11-TRIEN-3ONA. - Google Patents
PROCEDURE FOR OBTAINING 13-ALKYL-17 BETA-HIDRO-XI-17 ALPHA-PROPADIENYLGONE-4, 9 (10), 11-TRIEN-3ONA.Info
- Publication number
- ES390456A1 ES390456A1 ES390456A ES390456A ES390456A1 ES 390456 A1 ES390456 A1 ES 390456A1 ES 390456 A ES390456 A ES 390456A ES 390456 A ES390456 A ES 390456A ES 390456 A1 ES390456 A1 ES 390456A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- trien
- alkyl
- procedure
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical group [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical compound N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Abstract
Procedure for obtaining 13-alkyl-17β-hydroxy-17α-propadienylgon-4,9 (10), 11-trien-3-one, of formula I, ** (See formula) ** wherein R is a methyl, ethyl or n-propyl radical, characterized in that a compound of formula-II is treated, where R has the meaning indicated above, with a compound of formula X, ** (See formula) ** wherein each of Z, Z1, Z2 and Z3, which may be the same or different, signifies a chlorine or bromine atom or a cyano radical, in an inert organic solvent. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3178270A | 1970-04-24 | 1970-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES390456A1 true ES390456A1 (en) | 1974-07-01 |
Family
ID=21861362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES390456A Expired ES390456A1 (en) | 1970-04-24 | 1971-04-22 | PROCEDURE FOR OBTAINING 13-ALKYL-17 BETA-HIDRO-XI-17 ALPHA-PROPADIENYLGONE-4, 9 (10), 11-TRIEN-3ONA. |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | ATA353071A (en) |
| AU (1) | AU2810571A (en) |
| BE (1) | BE766148A (en) |
| CA (1) | CA945141A (en) |
| CS (1) | CS155974B2 (en) |
| DE (1) | DE2119328A1 (en) |
| ES (1) | ES390456A1 (en) |
| FR (1) | FR2092083B1 (en) |
| GB (1) | GB1348186A (en) |
| NL (1) | NL7105446A (en) |
| ZA (2) | ZA712601B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL127071C (en) * | 1964-12-31 | |||
| IL34228A (en) * | 1969-04-18 | 1975-04-25 | Syntex Corp | The preparation of 17alpha-propadienyl steroids and novel 17alpha-(3-substituted propynyl)steroidal intermediates |
-
1971
- 1971-04-19 GB GB993171*[A patent/GB1348186A/en not_active Expired
- 1971-04-21 DE DE19712119328 patent/DE2119328A1/en active Pending
- 1971-04-22 BE BE766148A patent/BE766148A/en unknown
- 1971-04-22 CA CA111,058A patent/CA945141A/en not_active Expired
- 1971-04-22 FR FR7114358A patent/FR2092083B1/fr not_active Expired
- 1971-04-22 NL NL7105446A patent/NL7105446A/xx unknown
- 1971-04-22 ES ES390456A patent/ES390456A1/en not_active Expired
- 1971-04-22 ZA ZA712601A patent/ZA712601B/en unknown
- 1971-04-23 AU AU28105/71A patent/AU2810571A/en not_active Expired
- 1971-04-23 AT AT713530A patent/ATA353071A/en not_active IP Right Cessation
- 1971-04-23 ZA ZA712643A patent/ZA712643B/en unknown
- 1971-04-23 CS CS299571A patent/CS155974B2/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2810571A (en) | 1972-10-26 |
| GB1348186A (en) | 1974-03-13 |
| NL7105446A (en) | 1971-10-26 |
| FR2092083B1 (en) | 1974-08-23 |
| ZA712643B (en) | 1972-11-29 |
| FR2092083A1 (en) | 1972-01-21 |
| ATA353071A (en) | 1975-02-15 |
| CS155974B2 (en) | 1974-06-24 |
| CA945141A (en) | 1974-04-09 |
| DE2119328A1 (en) | 1971-11-11 |
| BE766148A (en) | 1971-10-22 |
| ZA712601B (en) | 1972-11-29 |
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