ES391802A1 - A procedure for the preparation of azines (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A method of preparing azines of formula I **(See formula)** where the radicals R1 and R2 at most can be hydrogen atoms, the other or the other two linear or branched alkyl radicals or cycloalkyl containing up to approximately 12 carbon atoms or a hydrocarbon radical of 6 to 12 carbon atoms, containing a nucleus benzene, optionally substituted with stable groups in the reaction medium, such as chlorine, bromine, fluorine, nitro, methoxy, etc .; whose procedure consists of reacting ammonia with a carbonyl derivative R1-CO-R2 (II) and hydrogen peroxide, in the presence of a nitrile R3- (CN) n, where n is between 1 and 6 and where R3 is a radical hydrocarbon containing up to 12 carbon atoms that can be saturated, acyclic or cyclic aliphatic or that can contain an aromatic nucleus selected from benzene and pyridic nuclei, these radicals being able to be substituted with 1 to 6 the same or different groups, preferably selected among which they are not oxidized under the reaction conditions, such as amide, carboxylic acid and ester groups, nitro, primary amine, secondary amine, tertiary amine, amine oxide, fluorine, chlorine, bromine, iodine, hydroxy, ether-oxide, acetal, ether-epoxy, sulfoxide, sulfide, sulfone and sulfonic acid. (Machine-translation by Google Translate, not legally binding)