ES397573A1 - Biologically active imidazoles - Google Patents
Biologically active imidazolesInfo
- Publication number
- ES397573A1 ES397573A1 ES397573A ES397573A ES397573A1 ES 397573 A1 ES397573 A1 ES 397573A1 ES 397573 A ES397573 A ES 397573A ES 397573 A ES397573 A ES 397573A ES 397573 A1 ES397573 A1 ES 397573A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- optionally substituted
- groups
- hydroxyl
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 125000002887 hydroxy group Chemical class [H]O* 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001302 tertiary amino group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for the preparation of new substituted imidazoles of general formula (VI) ** formula ** or a tautomeric or structural isomer thereof as defined above, where R1 is a carbocyclic or heterocyclic aromatic group, optionally substituted with one or more atoms optionally substituted halogen, hydroxyl, amino, thiol, sulfonic, or carboxylic groups or cyano, nitro, acyl, alkyl, aryl, or haloalkyl groups; R2 is an amino or hydroxyl group or an alkoxy, aryloxy or aralkoxy group optionally substituted with one or more halogen atoms or optionally substituted hydroxyl or tertiary amino groups, R4 is a hydrogen atom or a methyl group, R3 is an N = group N-NR5R6, where R5 is a beta-halogenated methyl or ethyl group and R6 is a hydrogen atom or a hydrocarbon group optionally substituted with a halogen atom or an optionally substituted tertiary amino or hydroxyl group and addition salts with acids, solvates or addition salts with solvated acids thereof, the process of which comprises the step of reacting the compound of the general formula ** formula ** where R''4 is a negative casing or a methyl group, with a compound of the general formula HNR5R6, whereupon optionally, if desired, replacing or modifying groups R1, R2 and/or R4 to provide other groups, R1, R2 and/or R4 by known method. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5838570A GB1373346A (en) | 1970-12-09 | 1970-12-09 | Biologically active imidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES397573A1 true ES397573A1 (en) | 1975-10-01 |
Family
ID=10481482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES397573A Expired ES397573A1 (en) | 1970-12-09 | 1971-12-01 | Biologically active imidazoles |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | AT310740B (en) |
| BE (1) | BE776422A (en) |
| CA (1) | CA979428A (en) |
| DE (1) | DE2161209A1 (en) |
| ES (1) | ES397573A1 (en) |
| FR (1) | FR2117939B1 (en) |
| GB (1) | GB1373346A (en) |
| HU (1) | HU163484B (en) |
| IE (1) | IE35817B1 (en) |
| IL (1) | IL38174A0 (en) |
| NL (1) | NL7116331A (en) |
| SE (1) | SE7412430L (en) |
| ZA (1) | ZA717873B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019113227A1 (en) * | 2017-12-06 | 2019-06-13 | Yale University | Prodrugs activated by reduction in the cytosol |
-
1970
- 1970-12-09 GB GB5838570A patent/GB1373346A/en not_active Expired
-
1971
- 1971-11-17 IE IE1448/71A patent/IE35817B1/en unknown
- 1971-11-18 IL IL38174A patent/IL38174A0/en unknown
- 1971-11-23 ZA ZA717873A patent/ZA717873B/en unknown
- 1971-11-26 NL NL7116331A patent/NL7116331A/xx unknown
- 1971-11-26 CA CA128,705A patent/CA979428A/en not_active Expired
- 1971-12-01 ES ES397573A patent/ES397573A1/en not_active Expired
- 1971-12-03 AT AT1042171A patent/AT310740B/en not_active IP Right Cessation
- 1971-12-08 BE BE776422A patent/BE776422A/en unknown
- 1971-12-08 FR FR7144014A patent/FR2117939B1/fr not_active Expired
- 1971-12-09 DE DE19712161209 patent/DE2161209A1/en active Pending
- 1971-12-09 HU HUBE1108A patent/HU163484B/hu unknown
-
1974
- 1974-10-02 SE SE7412430A patent/SE7412430L/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AT310740B (en) | 1973-10-10 |
| ZA717873B (en) | 1972-08-30 |
| IL38174A0 (en) | 1972-01-27 |
| SE7412430L (en) | 1974-10-02 |
| HU163484B (en) | 1973-09-27 |
| GB1373346A (en) | 1974-11-13 |
| AU3658871A (en) | 1973-06-14 |
| BE776422A (en) | 1972-06-08 |
| DE2161209A1 (en) | 1972-06-22 |
| IE35817L (en) | 1972-06-09 |
| FR2117939A1 (en) | 1972-07-28 |
| FR2117939B1 (en) | 1975-06-13 |
| NL7116331A (en) | 1972-06-13 |
| CA979428A (en) | 1975-12-09 |
| IE35817B1 (en) | 1976-05-26 |
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