ES401941A1 - Procedimiento para la preparacion de 1,2,3,4-tetrahidroisoquinolinas - Google Patents
Procedimiento para la preparacion de 1,2,3,4-tetrahidroisoquinolinasInfo
- Publication number
- ES401941A1 ES401941A1 ES0401941A ES401941A ES401941A1 ES 401941 A1 ES401941 A1 ES 401941A1 ES 0401941 A ES0401941 A ES 0401941A ES 401941 A ES401941 A ES 401941A ES 401941 A1 ES401941 A1 ES 401941A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- translation
- preparation
- machine
- legally binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical class C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 abstract 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- HSEKIORHFYSLRN-UHFFFAOYSA-N 2-(3-chloropropanoyl)-N'-hydroxybenzenecarboximidamide Chemical compound ClCCC(=O)C1=C(C(N)=NO)C=CC=C1 HSEKIORHFYSLRN-UHFFFAOYSA-N 0.000 abstract 1
- PSRZKYADWWQZMS-UHFFFAOYSA-N C1(NCCC2=CC=CC=C12)CCN1OC=NC1 Chemical class C1(NCCC2=CC=CC=C12)CCN1OC=NC1 PSRZKYADWWQZMS-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000010533 azeotropic distillation Methods 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedimiento para la preparación de 1,2,3,4-tetrahidroisoquinolinas, y en especial del 3- fenil-5(2[2-(1,2,3,4-tetrahidroisoquinolinil)-etil])-1,2,4-oxadiazoles, componente activo en formulaciones para el tratamiento clínico de afecciones en las vías respitarorias de la fórmula general **fórmula** en la que R representa hidrógeno o un grupo de metoxilo, R'' representa hidrógeno , metilo, etilo o n-propilo y R''` representa hidrógeno o metilo, caracterizado por el hecho de que se hace reaccionar beta-cloropropionil-benzamidoxima con una tetrahidroisoquinolina de la fórmula **fórmula** donde los substituyentes tienen el mismo significado antes expuesto en presencia de una sustancia apta para captar el ácido clorhídrico eliminando el agua, que se forma en el curso de la reacción , mediante destilación azeotrópica con benceno
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2352871A IT1043838B (it) | 1971-04-22 | 1971-04-22 | 1 2 3 4 tetraidroisochinoline e processo per la loro preparazione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES401941A1 true ES401941A1 (es) | 1975-03-01 |
Family
ID=11207867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0401941A Expired ES401941A1 (es) | 1971-04-22 | 1972-04-20 | Procedimiento para la preparacion de 1,2,3,4-tetrahidroisoquinolinas |
Country Status (8)
| Country | Link |
|---|---|
| AR (1) | AR192360A1 (es) |
| BE (1) | BE782182A (es) |
| DE (1) | DE2219418B2 (es) |
| ES (1) | ES401941A1 (es) |
| FR (1) | FR2134047B1 (es) |
| GB (1) | GB1381959A (es) |
| IT (1) | IT1043838B (es) |
| ZA (1) | ZA722503B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU180708B (en) * | 1979-10-11 | 1983-04-29 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new 1,2,4-oxadiazine derivatives |
| GB8529546D0 (en) * | 1985-11-30 | 1986-01-08 | Beecham Group Plc | Compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL120029C (es) * | 1959-09-29 |
-
1971
- 1971-04-22 IT IT2352871A patent/IT1043838B/it active
-
1972
- 1972-04-13 ZA ZA722503A patent/ZA722503B/xx unknown
- 1972-04-14 BE BE782182A patent/BE782182A/xx unknown
- 1972-04-20 ES ES0401941A patent/ES401941A1/es not_active Expired
- 1972-04-20 AR AR24157772A patent/AR192360A1/es active
- 1972-04-20 DE DE19722219418 patent/DE2219418B2/de active Granted
- 1972-04-21 FR FR7214318A patent/FR2134047B1/fr not_active Expired
- 1972-04-21 GB GB1860172A patent/GB1381959A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE782182A (fr) | 1972-07-31 |
| IT1043838B (it) | 1980-02-29 |
| DE2219418B2 (de) | 1974-03-14 |
| FR2134047A1 (es) | 1972-12-01 |
| AR192360A1 (es) | 1973-02-14 |
| ZA722503B (en) | 1973-07-25 |
| GB1381959A (en) | 1975-01-29 |
| DE2219418A1 (de) | 1972-11-02 |
| FR2134047B1 (es) | 1975-12-26 |
| DE2219418C3 (es) | 1974-10-10 |
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