ES404174A1 - PROCEDURE FOR OBTAINING SUBSTITUTE OXIDOLS. - Google Patents
PROCEDURE FOR OBTAINING SUBSTITUTE OXIDOLS.Info
- Publication number
- ES404174A1 ES404174A1 ES404174A ES404174A ES404174A1 ES 404174 A1 ES404174 A1 ES 404174A1 ES 404174 A ES404174 A ES 404174A ES 404174 A ES404174 A ES 404174A ES 404174 A1 ES404174 A1 ES 404174A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- formula
- separated
- nitrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 12
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- -1 aminopropoxy side chain Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000005623 oxindoles Chemical class 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
Landscapes
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedure for obtaining substituted oxindoles, of formula I, **(See formula)** wherein R1 is hydrogen or C1-C4-alkyl, R2 is C1-C6-alkyl; cycloalkyl of 3 to 8 carbon atoms; alkoxyalkyl of 3 to 10 carbon atoms, the oxygen atom thereof being separated from the nitrogen atom by at least two carbon atoms; phenylalkyl of 8 to 12 carbon atoms, the phenyl being separated from the nitrogen atom by at least two carbon atoms; phenylalkyl of 8 to 12 carbon atoms, monosubstituted by alkyl of 1 to 5 carbon atoms or alkoxy of 1 to 5 carbon atoms, the phenyl being separated from the nitrogen atom by at least two carbon atoms; alkynyl of 2 to 7 carbon atoms; or carbalkoxyalkyl, whose alkoxy substituent has 1 to 4 carbon atoms, and whose alkyl substituent has 1 to 6 carbon atoms; R3 is hydrogen, and where the aminopropoxy side chain is in position 4 or 7 of the oxindolic nucleus, characterized in that a compound of formula III is reacted, **(See formula)** where R1 has the meaning indicated above, and the epoxypropoxy side chain is in position 4 or 7 of the oxindolic nucleus, with an amine of formula IV, H2NR2 IV wherein R2 has the meaning indicated above, preferably in an inert organic solvent, preferably at a temperature of 20 to 150ºC. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH924871A CH547801A (en) | 1971-06-24 | 1971-06-24 | 4 and 7-Aminopropoyx-oxindole derivs - useful as anti-arrhythmics and beta-adrenergic blockers |
| CH924771A CH547800A (en) | 1971-06-24 | 1971-06-24 | 4 and 7-Aminopropoyx-oxindole derivs - useful as anti-arrhythmics and beta-adrenergic blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES404174A1 true ES404174A1 (en) | 1975-11-16 |
Family
ID=25704505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES404174A Expired ES404174A1 (en) | 1971-06-24 | 1972-06-23 | PROCEDURE FOR OBTAINING SUBSTITUTE OXIDOLS. |
Country Status (3)
| Country | Link |
|---|---|
| ES (1) | ES404174A1 (en) |
| PL (1) | PL83679B1 (en) |
| RO (1) | RO62636A (en) |
-
1972
- 1972-06-22 PL PL15620572A patent/PL83679B1/pl unknown
- 1972-06-22 RO RO7483072A patent/RO62636A/en unknown
- 1972-06-23 ES ES404174A patent/ES404174A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| RO62636A (en) | 1978-05-15 |
| PL83679B1 (en) | 1975-12-31 |
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