ES408403A1 - Procedure for the preparation of oxolynic acid. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of oxolynic acid. (Machine-translation by Google Translate, not legally binding)

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Publication number
ES408403A1
ES408403A1 ES408403A ES408403A ES408403A1 ES 408403 A1 ES408403 A1 ES 408403A1 ES 408403 A ES408403 A ES 408403A ES 408403 A ES408403 A ES 408403A ES 408403 A1 ES408403 A1 ES 408403A1
Authority
ES
Spain
Prior art keywords
compound
see formula
acid
translation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES408403A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHIMICO FARMACEUTICO DR P BLAS
Original Assignee
CHIMICO FARMACEUTICO DR P BLAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHIMICO FARMACEUTICO DR P BLAS filed Critical CHIMICO FARMACEUTICO DR P BLAS
Publication of ES408403A1 publication Critical patent/ES408403A1/en
Expired legal-status Critical Current

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Procedure for the preparation of oxolinic acid of the structural formula: **(See formula)** characterized by reacting a compound of structure (III) **(See formula)** where R = R1 = H or R and R1, together, represent the group -O-CH2-O-, with hot diethyl malonate, to obtain a compound of structure (IV) **(See formula)** which cyclizes by rapid heating to 250-260ºC, becoming a respective quinoline derivative of the structure (V) **(See formula)** which, by alkylation on the heterocyclic nitrogen with a compound taken from the group consisting of ethyl halide and an ethyl ester of an ethyl donor inorganic acid, in the presence or absence of a polar or apolar solvent, gives the respective compound of the structure (VI) **(See formula)** where R and R1 have the same meaning as before, and this compound (VI), by ambient or alkaline hydrolysis, gives the end the oxolinic acid. (Machine-translation by Google Translate, not legally binding)
ES408403A 1972-07-26 1972-11-09 Procedure for the preparation of oxolynic acid. (Machine-translation by Google Translate, not legally binding) Expired ES408403A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2743772 1972-07-26

Publications (1)

Publication Number Publication Date
ES408403A1 true ES408403A1 (en) 1976-01-16

Family

ID=11221635

Family Applications (1)

Application Number Title Priority Date Filing Date
ES408403A Expired ES408403A1 (en) 1972-07-26 1972-11-09 Procedure for the preparation of oxolynic acid. (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES408403A1 (en)

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