ES414231A1 - Procedure for the preparation of benzodiazepin-2-onas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of benzodiazepin-2-onas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES414231A1 ES414231A1 ES414231A ES414231A ES414231A1 ES 414231 A1 ES414231 A1 ES 414231A1 ES 414231 A ES414231 A ES 414231A ES 414231 A ES414231 A ES 414231A ES 414231 A1 ES414231 A1 ES 414231A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- acid addition
- addition salts
- groups
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000003158 alcohol group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 125000002560 nitrile group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedure for the preparation of benzodiazepin-2-one of general formula **(See formula)** where R1 represents hydrogen or a low molecular weight alcohol radical, which can be linear, branched or cyclic, and possibly can also be substituted, and A and B represent phenyl radicals, which can be substituted by one or more substituents such as nitro, trifluoromethyl, halogen, alcohol or alkoxy, as well as by their acid addition salts, characterized in that a compound of the general formula **(See formula)** where R1, A and B have the same meaning indicated above, and R2 represents a halogen atom, a nitrile group or a carboxyl group, or a derivative that can be obtained from them; also a free, esterified or etherified hydroxyl group, or a group (see formula), in which R3 and R4 can be identical or different, and hydrogen atoms, acyl groups or straight or branched chain alcohol groups, saturated or unsaturated, the alcohol groups being able to be linked to each other also directly or by means of of a heteroatom, which, when it is a nitrogen atom, can also have a substituent; and R3 and R4 further represent aryl, aralkoxy or aryloxyalkyl groups, which may optionally be substituted, or their acid addition salts, are subjected to oxidation with an appropriate oxidizing agent in the presence of an inert solvent, and the bases or their acid addition salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722221536 DE2221536A1 (en) | 1972-05-03 | 1972-05-03 | Benzodiazepin-2-ones prepn - by oxidn of 5-phenyl -2,3-dihydro-2-(substd methyl)-1,4-benzodiazepines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES414231A1 true ES414231A1 (en) | 1976-01-16 |
Family
ID=5843890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES414231A Expired ES414231A1 (en) | 1972-05-03 | 1973-04-30 | Procedure for the preparation of benzodiazepin-2-onas. (Machine-translation by Google Translate, not legally binding) |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5341159B2 (en) |
| KR (1) | KR780000053B1 (en) |
| AT (1) | AT332875B (en) |
| CH (1) | CH574943A5 (en) |
| DD (1) | DD105221A5 (en) |
| DE (1) | DE2221536A1 (en) |
| DK (1) | DK137184C (en) |
| ES (1) | ES414231A1 (en) |
| NO (1) | NO137444C (en) |
| SE (1) | SE409710B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2754112A1 (en) * | 1977-12-05 | 1979-06-13 | Kali Chemie Pharma Gmbh | 1,4-BENZODIAZEPINE DERIVATIVES, THEIR SALTS AND MEDICINAL PREPARATIONS CONTAINING THESE COMPOUNDS |
-
1972
- 1972-05-03 DE DE19722221536 patent/DE2221536A1/en not_active Ceased
-
1973
- 1973-03-28 CH CH448973A patent/CH574943A5/xx not_active IP Right Cessation
- 1973-04-09 DD DD170141A patent/DD105221A5/xx unknown
- 1973-04-30 ES ES414231A patent/ES414231A1/en not_active Expired
- 1973-05-01 JP JP4900473A patent/JPS5341159B2/ja not_active Expired
- 1973-05-02 NO NO1796/73A patent/NO137444C/en unknown
- 1973-05-02 SE SE7306127A patent/SE409710B/en unknown
- 1973-05-02 DK DK238473A patent/DK137184C/en active
- 1973-05-03 AT AT389773A patent/AT332875B/en not_active IP Right Cessation
- 1973-05-03 KR KR7300715A patent/KR780000053B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE409710B (en) | 1979-09-03 |
| JPS4941390A (en) | 1974-04-18 |
| NO137444B (en) | 1977-11-21 |
| CH574943A5 (en) | 1976-04-30 |
| NO137444C (en) | 1978-03-01 |
| ATA389773A (en) | 1976-02-15 |
| JPS5341159B2 (en) | 1978-10-31 |
| DK137184C (en) | 1978-07-03 |
| DE2221536A1 (en) | 1973-11-22 |
| DD105221A5 (en) | 1974-04-12 |
| AT332875B (en) | 1976-10-25 |
| DK137184B (en) | 1978-01-30 |
| KR780000053B1 (en) | 1978-03-16 |
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