ES414321A1 - A PROCEDURE FOR THE PREPARATION OF A PIRAZI-NICO PRODUCT. - Google Patents

A PROCEDURE FOR THE PREPARATION OF A PIRAZI-NICO PRODUCT.

Info

Publication number
ES414321A1
ES414321A1 ES414321A ES414321A ES414321A1 ES 414321 A1 ES414321 A1 ES 414321A1 ES 414321 A ES414321 A ES 414321A ES 414321 A ES414321 A ES 414321A ES 414321 A1 ES414321 A1 ES 414321A1
Authority
ES
Spain
Prior art keywords
alkyl
procedure
preparation
straight
branched chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES414321A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp & Dohme (I.A.) Corp
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp & Dohme (I.A.) Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp & Dohme (I.A.) Corp filed Critical Merck Sharp and Dohme Ltd
Publication of ES414321A1 publication Critical patent/ES414321A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A procedure for the preparation of a pyrazinic product of structure I ** (See formula) ** by reaction of compounds of structures II and III, in the presence of a base, followed by treatment with a mineral acid ** (See formula) ** where, in each of the structures, R represents C1-5 alkyl or phenyl; R1 represents straight or branched chain C3-6 alkyl, straight or branched chain C3-6 hydroxyalkyl, straight or branched chain alkynyl, C1-6 phenylalkyl or indolyl-C1-6 alkyl; R2 represents chlorine or hydroxy; R3 represents hydrogen or X-sulfonyl, where X represents alkyl, aryl or arylalkyl; and R4 represents hydrogen, lower alkyl and phenyl and when R2 is chlorine, R3 is hydrogen and when R2 is hydroxy, then R3 is X-sulfonyl. (Machine-translation by Google Translate, not legally binding)
ES414321A 1972-05-05 1973-05-03 A PROCEDURE FOR THE PREPARATION OF A PIRAZI-NICO PRODUCT. Expired ES414321A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA141,471A CA1001631A (en) 1972-05-05 1972-05-05 2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation

Publications (1)

Publication Number Publication Date
ES414321A1 true ES414321A1 (en) 1976-02-01

Family

ID=4093189

Family Applications (1)

Application Number Title Priority Date Filing Date
ES414321A Expired ES414321A1 (en) 1972-05-05 1973-05-03 A PROCEDURE FOR THE PREPARATION OF A PIRAZI-NICO PRODUCT.

Country Status (13)

Country Link
JP (1) JPS584026B2 (en)
AU (1) AU474809B2 (en)
BE (1) BE799099A (en)
CA (1) CA1001631A (en)
CH (1) CH580603A5 (en)
DE (1) DE2322362A1 (en)
ES (1) ES414321A1 (en)
FR (1) FR2183752B1 (en)
GB (1) GB1390329A (en)
HU (1) HU167634B (en)
NL (1) NL7305480A (en)
SE (1) SE398500B (en)
ZA (1) ZA733051B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR206801A1 (en) * 1973-02-20 1976-08-23 Ciba Geigy Ag PROCEDURE FOR THE ELABORATION OF DERIVATIVES OF 1-PIRID LOXI-2-HIDROXI-3-AMINO-PROPAN
JPS5839832B2 (en) * 1974-02-20 1983-09-01 チバ ガイギ− アクチエンゲゼルシヤフト Production method of new pyrazine compound
US4060601A (en) * 1976-06-15 1977-11-29 Merck & Co., Inc. Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines
JP2830387B2 (en) * 1990-06-08 1998-12-02 株式会社明電舎 Tire effective radius measurement method
KR0138005B1 (en) * 1993-10-21 1998-05-15 김낙두 Novel chemopreventive agents and preparation methods thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1473815A (en) * 1962-11-16 1967-03-24 Nl Combinatie Chem Ind Process for preparing tertiary amines and novel compounds thus obtained

Also Published As

Publication number Publication date
FR2183752B1 (en) 1976-03-05
JPS4961181A (en) 1974-06-13
BE799099A (en) 1973-11-05
ZA733051B (en) 1974-12-24
CA1001631A (en) 1976-12-14
CH580603A5 (en) 1976-10-15
AU474809B2 (en) 1976-08-05
SE398500B (en) 1977-12-27
DE2322362A1 (en) 1973-11-22
NL7305480A (en) 1973-11-07
FR2183752A1 (en) 1973-12-21
GB1390329A (en) 1975-04-09
JPS584026B2 (en) 1983-01-24
AU5493973A (en) 1974-10-31
HU167634B (en) 1975-11-28

Similar Documents

Publication Publication Date Title
MX171822B (en) CHEMICAL PROCESS
ES435246A1 (en) Piperidine derivatives
ES379880A1 (en) Procedure for the preparation of a fluoranum compound. (Machine-translation by Google Translate, not legally binding)
ES387834A1 (en) Acid amides
ES395380A1 (en) A PROCEDURE FOR THE PRODUCTION OF A CARBAMATE COMPOUND.
ES414320A1 (en) A PROCEDURE FOR THE PREPARATION OF A PIRAZOLE.
ES325146A1 (en) A PROCEDURE FOR THE PREPARATION OF AMINOISOXAZOLES.
ES396232A1 (en) PROCEDURE FOR THE PREPARATION OF TRIA-ZOLIL-TRIOFOSPHONIC ACID ESTERS.
ES419667A1 (en) Carboamates of 3,4,5-trimethoxy acetophenone oxime their process of preparation and their therapeutic application
ES394322A1 (en) PROCEDURE FOR THE PREPARATION OF SUBSTITUTED 2-BENZYPHENOLS.
ES392388A1 (en) PROCEDURE FOR THE PREPARATION OF TETRAHYDROPYRIDINE DERIVATIVES.
ES327297A1 (en) PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM QUINAZOLINE.
ES427983A1 (en) Functional fluids
ES428011A1 (en) PROCEDURE FOR THE PREPARATION OF 2-AMINO-3,5-DIBROMO-BENZYLAMINE.
ES388822A1 (en) Biocidal composition and disinfecting method
ES391263A1 (en) Mixture of quinophthalone dispense dyestuffs
FR2401131A1 (en) NEW O-HYDROXYNAPHTALDEHYDES, PROCESS FOR PREPARATION AND USE AS AN INTERMEDIATE OF SYNTHESES
GB1330611A (en) Fungicides for green plants
ES441429A2 (en) PROCEDURE FOR THE PRODUCTION OF AZOIC COMPOUNDS.
ES438651A1 (en) A PROCEDURE FOR THE PRODUCTION OF NEW DERIVATIVES OF PIRAZOLINE.
ES402115A1 (en) PROCEDURE FOR OBTAINING IMIDAZO (2,1-A) ISOINDOL DERIVATIVES.
ES430102A2 (en) Phenylacetic acid derivatives
ES314635A1 (en) Procedure for the preparation of new derivatives of azepine. (Machine-translation by Google Translate, not legally binding)
GB1301996A (en)
ES395942A1 (en) Quinazolone derivatives their production and their medicinal use

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19850516