ES414716A2 - Procedure for the preparation of aminoadamantanos. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of aminoadamantanos. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES414716A2 ES414716A2 ES414716A ES414716A ES414716A2 ES 414716 A2 ES414716 A2 ES 414716A2 ES 414716 A ES414716 A ES 414716A ES 414716 A ES414716 A ES 414716A ES 414716 A2 ES414716 A2 ES 414716A2
- Authority
- ES
- Spain
- Prior art keywords
- translation
- procedure
- preparation
- adamantyl
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 1 -adamantyl Chemical group 0.000 abstract 3
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical class C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- CPEONABTMRSIKA-UHFFFAOYSA-N 1,4$l^{2}-oxazinane Chemical compound C1COCC[N]1 CPEONABTMRSIKA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Improvements introduced in the object of the main patent No. 382,198, applied for on July 27, 1970, for: "Procedure for the preparation of aminoadamantanes", the improvements referring to aminoadamantane compounds of the general formula **(See formula)** wherein R1 and R2 are the same or different and signify a hydrogen atom or a methyl radical, and R3 signifies a methyl radical or together with -N-R2 signifies the morpholino radical, as well as its salts, starting from N- (1 -adamantyl) -1-halogenoacetamide or N-methyl, N- (1-adamantyl) -halogenoacetamide, characterized in that the starting material is reacted with alkali metal monoglycolate to form the β-hydroxyether, the hydroxyl group is changed by halogen using a halogenating agent and the N- (1-adamantyl) -2- (2-halogenoethoxy) -acetamide, obtained in this way, is reacted with the desired amine. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732316839 DE2316839C2 (en) | 1973-04-04 | 1973-04-04 | Process for the preparation of aminoadamantane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES414716A2 true ES414716A2 (en) | 1976-03-01 |
Family
ID=5876993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES414716A Expired ES414716A2 (en) | 1973-04-04 | 1973-05-12 | Procedure for the preparation of aminoadamantanos. (Machine-translation by Google Translate, not legally binding) |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5720295B2 (en) |
| AT (1) | AT325592B (en) |
| BE (1) | BE798609R (en) |
| CA (1) | CA962674A (en) |
| CH (1) | CH553748A (en) |
| DE (1) | DE2316839C2 (en) |
| ES (1) | ES414716A2 (en) |
| FR (1) | FR2224446B2 (en) |
| GB (1) | GB1432678A (en) |
| NL (1) | NL7306130A (en) |
| PL (1) | PL83827B1 (en) |
| SE (1) | SE385874B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6221991U (en) * | 1985-07-25 | 1987-02-09 |
-
1973
- 1973-04-04 DE DE19732316839 patent/DE2316839C2/en not_active Expired
- 1973-04-11 AT AT319473A patent/AT325592B/en not_active IP Right Cessation
- 1973-04-12 SE SE7305183A patent/SE385874B/en unknown
- 1973-04-19 CH CH566973A patent/CH553748A/en not_active IP Right Cessation
- 1973-04-24 BE BE130325A patent/BE798609R/en not_active IP Right Cessation
- 1973-04-24 GB GB1943573A patent/GB1432678A/en not_active Expired
- 1973-05-02 NL NL7306130A patent/NL7306130A/xx unknown
- 1973-05-09 JP JP5156473A patent/JPS5720295B2/ja not_active Expired
- 1973-05-12 ES ES414716A patent/ES414716A2/en not_active Expired
- 1973-06-04 CA CA173,060A patent/CA962674A/en not_active Expired
- 1973-06-22 PL PL16352173A patent/PL83827B1/pl unknown
- 1973-07-04 FR FR7324580A patent/FR2224446B2/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2316839C2 (en) | 1983-04-28 |
| CA962674A (en) | 1975-02-11 |
| PL83827B1 (en) | 1976-02-28 |
| JPS49127957A (en) | 1974-12-07 |
| GB1432678A (en) | 1976-04-22 |
| FR2224446B2 (en) | 1976-06-18 |
| NL7306130A (en) | 1974-10-08 |
| CH553748A (en) | 1974-09-13 |
| AT325592B (en) | 1975-10-27 |
| FR2224446A2 (en) | 1974-10-31 |
| JPS5720295B2 (en) | 1982-04-27 |
| SE385874B (en) | 1976-07-26 |
| DE2316839A1 (en) | 1974-10-17 |
| ATA319473A (en) | 1975-01-15 |
| BE798609R (en) | 1973-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD2A | Announcement of lapse in spain |
Effective date: 20170704 |