ES417073A1 - PROCEDURE FOR THE PREPARATION OF ACTIVE TRICYCLIC COMPOUNDS, SUCH AS SHOCK ABSORBERS OF THE CENTRAL NERVOUS SYSTEM AND NEUROLOPTICS. - Google Patents

Abstract

Procedure for the preparation of tricyclic compounds active as central nervous system and neuroleptic buffers of the general formula **(See formula)** in which n represents the number 2, 3 or 4, R1 represents a halogen atom or a group of lower alkyl, di (lower alkyl) sulfamoyl, nitro, amino, di (lower alkyl) amino or trifluoromethyl, X represents an oxygen atom or an imino group, (lower alkyl) imino or methylene, m represents the number 0 or 1 and R2 and R3 each represent a hydrogen atom, or R2 and R3 represent the grouping **(See formula)** and where the link indicated by a broken line may be hydrogenated, and its salts, whose process includes (a) reacting a compound of the general formula **(See formula)** in which R1 has the meaning indicated above and Y represents a part atom with a compound of the general formula **(See formula)** in which m, n, R2, R3 and X have the meaning indicated above, to obtain a compound of formula I in which the bond indicated by a broken line is hydrogenated, or, in an alternative thereof, (b) reducing a compound of the general formula **(See formula)** in which m, n, R1, R2, R3 and X have the meaning indicated above, to obtain a compound of formula I where the indicated bond with a broken line is hydrogenated, or, in a variant thereof, (c) reacting a compound of the general formula **(See formula)** in which R1 has the meaning indicated above, with a compound of the general formula **(See formula)** in which m, n, X, R2 and R3 have the meaning indicated above, and Y has the meaning set forth above in this claim, to obtain a compound of formula I where the indicated bond with a broken line is hydrogenated, or in another alternative (d) reacting a compound of the general formula **(See formula)** in which R1 has the meaning indicated above, with a compound of formula III, set forth above in this claim, to obtain a compound of formula I wherein the bond indicated by a broken line is not hydrogenated and, in any case, if desired, reduce an indicated nitro group by R1 to obtain the amino group; proceed, if desired, to the di (lower alkylation) of an amino group indicated by and, convert, if desired, a compound of formula I obtained into a salt. (Machine-translation by Google Translate, not legally binding)