ES425892A1 - Procedure for the obtaining of new 2- (1- (2,3-dihydro-2-benzofuryl) -alkyl) -1,3,8-triazaespiro (4,5) decanes. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of new 2- (1- (2,3-dihydro-2-benzofuryl) -alkyl) -1,3,8-triazaespiro (4,5) decanes. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES425892A1 ES425892A1 ES425892A ES425892A ES425892A1 ES 425892 A1 ES425892 A1 ES 425892A1 ES 425892 A ES425892 A ES 425892A ES 425892 A ES425892 A ES 425892A ES 425892 A1 ES425892 A1 ES 425892A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- signifies
- hydrogen
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 2,3-dihydro-2-benzofuryl Chemical group 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 150000003856 quaternary ammonium compounds Chemical class 0.000 abstract 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000003003 spiro group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procedure for obtaining new 8- [1- (2,3-dihydro-2-benzofuryl) -alkyl] -1,3,8-triazaspiro (4,5) -decanes of general formula I **(See formula)** wherein Ph signifies a 1,2-phenylene residue, each of the residues R1, R2 and R3 signifies hydrogen or lower alkyl, each of the residues alk1 and alk2 signifies lower alkylene, which separates the nitrogen atom from the atom of spiro carbon by two ring carbon atoms, R4 signifies hydrogen, an aliphatic, araliphatic or aromatic moiety, R5 signifies two hydrogen atoms, hydrogen and lower alkyl or oxo, and R6 signifies hydrogen or lower alkyl, its acyl derivatives, N- oxides, quaternary ammonium compounds and salts, characterized in that a dehydro and/or hydroxy derivative of a compound of general formula VII is reduced **(See formula)** wherein the dotted lines represent optional bonds under corresponding deletion of the substituents on the atoms attached by them and where W stands for a free, or functionally modified, reaction-capable group of formula (see formula) or the formula group (see formula), when a double bond starts from at least one of the carbon atoms in position 2, and where the other general symbols have the indicated meaning and, if desired, a compound obtained from formula (I) is transforms into another compound of general formula (I) and/or a compound obtained from general formula (I) is transformed into its salts, acyl derivatives, N-oxides or quaternary ammonium compounds, and/or, if desired, a salt obtained is transformed into the free compound, and/or, if desired, a mixture of obtained isomers or racemates, are separated into the different isomers or racemates, and/or, if desired, the obtained racemates are dissociated at the optical antipodes . (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10512671A | 1971-01-08 | 1971-01-08 | |
| US00183694A US3826835A (en) | 1971-01-08 | 1971-09-24 | 8-benzofurylmethyl-1,3,8-triazaspiro(4,5)decanes as neuroleptics |
| CH1826571A CH590280A5 (en) | 1971-01-08 | 1971-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES425892A1 true ES425892A1 (en) | 1976-10-01 |
Family
ID=27177704
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES425891A Expired ES425891A1 (en) | 1971-01-08 | 1974-05-02 | Procedure for the obtaining of new 8- (1- (2,3-dihydro-2-benzofuryl) -alkyl) -1,3,8-triazaespiro (4,5) decanes. (Machine-translation by Google Translate, not legally binding) |
| ES425892A Expired ES425892A1 (en) | 1971-01-08 | 1974-05-02 | Procedure for the obtaining of new 2- (1- (2,3-dihydro-2-benzofuryl) -alkyl) -1,3,8-triazaespiro (4,5) decanes. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES425891A Expired ES425891A1 (en) | 1971-01-08 | 1974-05-02 | Procedure for the obtaining of new 8- (1- (2,3-dihydro-2-benzofuryl) -alkyl) -1,3,8-triazaespiro (4,5) decanes. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (2) | ES425891A1 (en) |
-
1974
- 1974-05-02 ES ES425891A patent/ES425891A1/en not_active Expired
- 1974-05-02 ES ES425892A patent/ES425892A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES425891A1 (en) | 1976-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES316050A1 (en) | Procedure for the preparation of derivatives of dibenzo (a, d) cicloheptatrieno. (Machine-translation by Google Translate, not legally binding) | |
| ES330368A1 (en) | Procedure for preparing N-alcohilamino-alcohilic derivatives of espirotetralinosuccinimidas and their salts. (Machine-translation by Google Translate, not legally binding) | |
| ES387016A1 (en) | Isoquinoline derivatives | |
| ES469821A1 (en) | Sesquiterpene derivatives having anti-complementary activity | |
| GB925429A (en) | Indole derivatives | |
| ES422738A1 (en) | N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation | |
| EP0089065A3 (en) | Novel phenylpiperazine derivatives and process for producing the same | |
| ES406551A1 (en) | 1,3,4-oxadiazolone derivatives | |
| ES425891A1 (en) | Procedure for the obtaining of new 8- (1- (2,3-dihydro-2-benzofuryl) -alkyl) -1,3,8-triazaespiro (4,5) decanes. (Machine-translation by Google Translate, not legally binding) | |
| ES407582A1 (en) | Halogenated 4-(4'-bisphenylyl)-butanols | |
| ES404745A1 (en) | Cephalosporin compounds | |
| ES312117A1 (en) | Procedure for the obtaining of diazacicloalcanicos compounds. (Machine-translation by Google Translate, not legally binding) | |
| ES393934A2 (en) | Derivatives of theophylline | |
| ES398670A1 (en) | Procedure for the obtaining of new 8 - (i- (2,3-dihydro-2-benzofuril) -alquil) -1,3,8-triazaespiro (4,5) -decanos. (Machine-translation by Google Translate, not legally binding) | |
| GB1104731A (en) | Conessine derivatives | |
| ES425350A1 (en) | Amines and process for their manufacture | |
| ES331825A1 (en) | Procedure for the obtaining of tetrahydro-aza-cicloalcan (i 2-a) pyracines. (Machine-translation by Google Translate, not legally binding) | |
| ES419386A1 (en) | Indenopyrrole derivatives | |
| GB1336399A (en) | 3-formylrifamycin sv derivatives | |
| CA2053705A1 (en) | Piperazine derivatives | |
| ES286563A1 (en) | Procedure for preparing new piperidine derivatives (Machine-translation by Google Translate, not legally binding) | |
| ES298514A1 (en) | A procedure for preparing a benzodiazocine compound (Machine-translation by Google Translate, not legally binding) | |
| GB1012622A (en) | New tropine derivatives | |
| ES388909A1 (en) | N-vinyl-quinolones | |
| ES394550A1 (en) | Tetrazole derivatives |