ES432467A1 - Procedure for the preparation of new derivatives of bifenilo. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new derivatives of bifenilo. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES432467A1 ES432467A1 ES432467A ES432467A ES432467A1 ES 432467 A1 ES432467 A1 ES 432467A1 ES 432467 A ES432467 A ES 432467A ES 432467 A ES432467 A ES 432467A ES 432467 A1 ES432467 A1 ES 432467A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- radical
- group
- formula
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000007529 inorganic bases Chemical class 0.000 abstract 2
- 150000002825 nitriles Chemical class 0.000 abstract 2
- 150000007530 organic bases Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000008363 butyronitriles Chemical class 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
- C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedure for the preparation of new biphenyl derivatives of the general formula I, **(See formula)** wherein the radical signifies a halogen atom and the radical B signifies the hydroxy group, an alkoxy or aralkoxy group or a group of the formula (see formula), in which R3, and R4, which may be the same or different from each other, represent hydrogen atoms, the carboxymethyl radical, a lower alcohol radical or a phenyl radical optionally substituted by a hydroxy or methyl group, and, if that B means the hydroxy group, of its salts with organic or inorganic bases, characterized in that for the preparation of compounds of the general formula I, in which the radical B represents the hydroxy group, biphenyl-butyronitriles of the formula are saponified general II **(See formula)** in which the radical has the meanings indicated above, in the presence of a base or an acid at temperatures between 100º and 200ºC or, for the preparation of the same compounds of the general formula I, butyronitriles of the general formula are saponified and decarboxylated IIa **(See formula)** wherein the radical R1 represents a halogen atom and the radical means the cyano or carboxamido group or a carboxyl group, which may optionally be esterified with an aliphatic or araliphatic alcohol or with a phenol: o Nitriles are reduced, saponified and decarboxylated the general formula IId **(See formula)** wherein the radicals R1 and Q are as defined above or, for the preparation of compounds of the general formula I, in which B means the free amino group, a nitrile of the general formula II is partially saponified; and the eventually obtained racemates are split by fractional crystallization of their salts with optically active bases into their two optically active individual components, and if desired, compounds obtained from the general formula I, in which B means the alkoxy group, or are saponified to form compounds of the general formula I, in which B represents the hydroxy group, and if desired, compounds obtained from the general formula I, in which B is the hydroxy group, are transformed according to methods customary in their esters or in its salts by means of organic or inorganic bases or, if desired, for the preparation of compounds of the general formula I, in which B means the radical (see formula) A compound of the general formula I, in which B represents an alkoxy group or a halogen atom, is reacted with a primary or secondary amine at elevated temperatures. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732322195 DE2322195A1 (en) | 1973-05-03 | 1973-05-03 | Antiphlogistic butyric acid derivs - 3-(halo-substd.-4-biphenylyl)-butyric acid derivs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES432467A1 true ES432467A1 (en) | 1976-11-16 |
Family
ID=5879859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES432467A Expired ES432467A1 (en) | 1973-05-03 | 1974-11-30 | Procedure for the preparation of new derivatives of bifenilo. (Machine-translation by Google Translate, not legally binding) |
Country Status (3)
| Country | Link |
|---|---|
| CS (1) | CS165389B2 (en) |
| DE (1) | DE2322195A1 (en) |
| ES (1) | ES432467A1 (en) |
-
1973
- 1973-05-03 DE DE19732322195 patent/DE2322195A1/en active Pending
- 1973-08-16 CS CS490673A patent/CS165389B2/cs unknown
-
1974
- 1974-11-30 ES ES432467A patent/ES432467A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CS165389B2 (en) | 1975-12-22 |
| DE2322195A1 (en) | 1974-11-21 |
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