ES435689A2 - 1-(beta-d-ribofuranosyl)-1,2,4-triazole acid derivatives - Google Patents

1-(beta-d-ribofuranosyl)-1,2,4-triazole acid derivatives

Info

Publication number
ES435689A2
ES435689A2 ES435689A ES435689A ES435689A2 ES 435689 A2 ES435689 A2 ES 435689A2 ES 435689 A ES435689 A ES 435689A ES 435689 A ES435689 A ES 435689A ES 435689 A2 ES435689 A2 ES 435689A2
Authority
ES
Spain
Prior art keywords
acyl
ribofuranosyl
beta
acid derivatives
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES435689A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch Health Americas Inc
Original Assignee
ICN Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/452,065 external-priority patent/US3984396A/en
Application filed by ICN Pharmaceuticals Inc filed Critical ICN Pharmaceuticals Inc
Publication of ES435689A2 publication Critical patent/ES435689A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Improvements made to the subject of the main patent No. 403,142 for "Procedure for the preparation of 1,2,4-triazole nucleosides" especially (ß -D-ribofuranosyl) -l, 2,4-triazole nucleosides of the structure **(See formula)** in which R1 is selected from the group consisting of a) carboxaraide, b) thiocarboxamide and c) carboxamidino groups and acid addition salts, physiologically acceptable from c) and in which X is hydrogen or C1-C18 acyl, being at least one X hydrogen and being at least one X acyl, characterized in that it is preferably acylated with an acyl halide or acyl anhydride, one or more of the free hydroxyl groups of a compound of the structure **(See formula)** in that it is as indicated above and isolating the product. (Machine-translation by Google Translate, not legally binding)
ES435689A 1974-03-18 1975-03-17 1-(beta-d-ribofuranosyl)-1,2,4-triazole acid derivatives Expired ES435689A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/452,065 US3984396A (en) 1971-06-01 1974-03-18 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters

Publications (1)

Publication Number Publication Date
ES435689A2 true ES435689A2 (en) 1977-10-16

Family

ID=23794869

Family Applications (1)

Application Number Title Priority Date Filing Date
ES435689A Expired ES435689A2 (en) 1974-03-18 1975-03-17 1-(beta-d-ribofuranosyl)-1,2,4-triazole acid derivatives

Country Status (13)

Country Link
JP (1) JPS50154253A (en)
AR (1) AR224992A1 (en)
BE (2) BE826776R (en)
CA (1) CA1060004A (en)
DE (2) DE2511828A1 (en)
DK (1) DK106375A (en)
ES (1) ES435689A2 (en)
FR (1) FR2264552B1 (en)
GB (1) GB1482736A (en)
NL (1) NL7503214A (en)
SE (1) SE7502995L (en)
YU (2) YU42137B (en)
ZA (1) ZA751662B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
TR200101085T2 (en) * 1998-10-16 2001-08-21 Schering Corporation Combined ribavirin-interferon alpha therapy for the elimination of detectable HCV-RNA in patients with chronic hepatitis C infection
US6277830B1 (en) 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US6924270B2 (en) 2000-04-20 2005-08-02 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
WO2009028575A1 (en) 2007-08-27 2009-03-05 National University Corporation Nagoya University Activator for blood coagulation factor vii promoter and utilization of the same
WO2009028573A1 (en) 2007-08-27 2009-03-05 National University Corporation Nagoya University Use of ribavirin in blood coagulation disorder
CN111205344B (en) * 2020-01-14 2023-03-14 华东理工大学 Pure organic phosphorescent small-molecule material for methanol solvent recognition and preparation method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3798209A (en) * 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides

Also Published As

Publication number Publication date
YU42137B (en) 1988-06-30
JPS50154253A (en) 1975-12-12
AR224992A1 (en) 1982-02-15
CA1060004A (en) 1979-08-07
GB1482736A (en) 1977-08-10
FR2264552A2 (en) 1975-10-17
SE7502995L (en) 1975-09-19
YU9287A (en) 1988-04-30
DE2560551C2 (en) 1989-02-23
BE826776R (en) 1975-07-16
DK106375A (en) 1975-09-19
AU7914575A (en) 1976-09-23
YU43291B (en) 1989-06-30
DE2511828A1 (en) 1975-10-02
BE903674Q (en) 1986-05-20
FR2264552B1 (en) 1980-12-19
ZA751662B (en) 1976-02-25
DE2511828C2 (en) 1991-01-17
NL7503214A (en) 1975-09-22
YU65775A (en) 1983-01-21

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20170705