ES438596A1 - PROCEDURE FOR OBTAINING BENZOCYCLO-HEPTATIOPHENE DERIVATIVES. - Google Patents
PROCEDURE FOR OBTAINING BENZOCYCLO-HEPTATIOPHENE DERIVATIVES.Info
- Publication number
- ES438596A1 ES438596A1 ES438596A ES438596A ES438596A1 ES 438596 A1 ES438596 A1 ES 438596A1 ES 438596 A ES438596 A ES 438596A ES 438596 A ES438596 A ES 438596A ES 438596 A1 ES438596 A1 ES 438596A1
- Authority
- ES
- Spain
- Prior art keywords
- benzocycloheptathiophene
- procedure
- obtaining
- formula
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 fluoro- Chemical class 0.000 abstract 5
- 150000008617 benzocycloheptathiophenes Chemical class 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedure for obtaining benzocycloheptathiophene derivatives of formula I, **(See formula)** where R1 is hydrogen, chlorine, bromine or alkoxy of 1 to 4 carbon atoms and is in position 6 or 7 of the benzocycloheptathiophene nucleus, R2 is alkyl of 1 to 4 carbon atoms; benzyl; fluoro-, chloro- or bromo-substituted benzyl; diphenylmethyl; or fluoro-, chloro- or bromo-substituted diphenylmethyl, and/or one of a and a is hydroxyiminomethylene and the other is methylene, characterized in that a compound of formula II is reacted, **(See formula)** where R1 and R2 have the meanings indicated above, and the oxo group is in position 9 or 10 of the benzocycloheptathiophene nucleus, with hydroxylamine, preferably in an inert organic solvent, preferably at room temperature and at reflux temperature. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH98872A CH565172A5 (en) | 1972-01-24 | 1972-01-24 | 4-piperidylidene benzocycloheptathiophenes - - antihistamines and serotonin and acetyl choline inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES438596A1 true ES438596A1 (en) | 1977-09-01 |
Family
ID=4199855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES438596A Expired ES438596A1 (en) | 1972-01-24 | 1975-06-16 | PROCEDURE FOR OBTAINING BENZOCYCLO-HEPTATIOPHENE DERIVATIVES. |
Country Status (6)
| Country | Link |
|---|---|
| CH (1) | CH565172A5 (en) |
| CS (1) | CS180000B2 (en) |
| DK (1) | DK134405B (en) |
| ES (1) | ES438596A1 (en) |
| PL (1) | PL92124B1 (en) |
| SU (1) | SU505364A3 (en) |
-
1972
- 1972-01-24 CH CH98872A patent/CH565172A5/en not_active IP Right Cessation
-
1973
- 1973-01-15 DK DK22573A patent/DK134405B/en not_active IP Right Cessation
- 1973-01-22 PL PL18205073A patent/PL92124B1/pl unknown
- 1973-01-23 CS CS415273A patent/CS180000B2/en unknown
-
1974
- 1974-05-28 SU SU2027852A patent/SU505364A3/en active
-
1975
- 1975-06-16 ES ES438596A patent/ES438596A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CS180000B2 (en) | 1977-12-30 |
| DK134405B (en) | 1976-11-01 |
| PL92124B1 (en) | 1977-03-31 |
| CH565172A5 (en) | 1975-08-15 |
| DK134405C (en) | 1977-03-28 |
| SU505364A3 (en) | 1976-02-28 |
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