ES439014A1 - A PROCEDURE TO PRODUCE BENZOISOXAZOLE COMPOUNDS. - Google Patents
A PROCEDURE TO PRODUCE BENZOISOXAZOLE COMPOUNDS.Info
- Publication number
- ES439014A1 ES439014A1 ES439014A ES439014A ES439014A1 ES 439014 A1 ES439014 A1 ES 439014A1 ES 439014 A ES439014 A ES 439014A ES 439014 A ES439014 A ES 439014A ES 439014 A1 ES439014 A1 ES 439014A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- benzoisoxazole
- formula
- agents
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Nuevos derivados de benzoisoxazol proporcionados por esta invención son los compuestos de benzoisoxazol de fórmula: **(Fórmula)** Los compuestos de fórmula donde R1 representa un grupo alcoxilo inferior y R3 y R4 son , cada uno, un grupo alquilo inferior presentan, en general, poderosas actividades inhibidoras de la agregación de plaquetas inducida por ADP y por colágeno"in vitro". Debido a que estos agentes de anti-agregación de plaquetas se consideran como unos de los más deseables agentes de anti-trombosis, pueden ser útiles como tales agentes. Los compuestos de benzoisoxazol (I) y sus sales farmacéuticamente aceptables pueden administrarse parenteral u oralmente.New benzoisoxazole derivatives provided by this invention are the benzoisoxazole compounds of the formula: **(Formula)** The compounds of the formula where R1 represents a lower alkoxy group and R3 and R4 are each a lower alkyl group present, in In general, potent inhibitory activities of ADP- and collagen-induced platelet aggregation "in vitro". Since these anti-platelet aggregation agents are considered to be some of the most desirable anti-thrombosis agents, they may be useful as such agents. The benzoisoxazole compounds (I) and their pharmaceutically acceptable salts can be administered parenterally or orally.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP49075544A JPS5826348B2 (en) | 1974-07-01 | 1974-07-01 | Method for producing new benzisoxazole derivatives |
| JP49088556A JPS5826349B2 (en) | 1974-07-31 | 1974-07-31 | Shinkibenzisoxazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES439014A1 true ES439014A1 (en) | 1978-03-01 |
Family
ID=26416679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439014A Expired ES439014A1 (en) | 1974-07-01 | 1975-06-30 | A PROCEDURE TO PRODUCE BENZOISOXAZOLE COMPOUNDS. |
Country Status (14)
| Country | Link |
|---|---|
| AR (1) | AR207986A1 (en) |
| AT (1) | AT344162B (en) |
| CA (1) | CA1051430A (en) |
| CH (1) | CH612189A5 (en) |
| DE (1) | DE2529292A1 (en) |
| DK (1) | DK294175A (en) |
| ES (1) | ES439014A1 (en) |
| FI (1) | FI59586C (en) |
| FR (1) | FR2276820A1 (en) |
| GB (1) | GB1502384A (en) |
| HU (1) | HU173527B (en) |
| NL (1) | NL7507835A (en) |
| NO (1) | NO142910C (en) |
| SE (1) | SE7507365L (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
-
1975
- 1975-01-01 AR AR259426A patent/AR207986A1/en active
- 1975-06-24 NO NO752245A patent/NO142910C/en unknown
- 1975-06-25 CA CA230,174A patent/CA1051430A/en not_active Expired
- 1975-06-26 SE SE7507365A patent/SE7507365L/en not_active Application Discontinuation
- 1975-06-26 FI FI751890A patent/FI59586C/en not_active IP Right Cessation
- 1975-06-27 DK DK294175A patent/DK294175A/en not_active Application Discontinuation
- 1975-06-27 HU HU75SU894A patent/HU173527B/en unknown
- 1975-06-27 GB GB27200/75A patent/GB1502384A/en not_active Expired
- 1975-06-30 AT AT498675A patent/AT344162B/en not_active IP Right Cessation
- 1975-06-30 ES ES439014A patent/ES439014A1/en not_active Expired
- 1975-06-30 FR FR7520521A patent/FR2276820A1/en not_active Withdrawn
- 1975-06-30 CH CH849075A patent/CH612189A5/en not_active IP Right Cessation
- 1975-07-01 NL NL7507835A patent/NL7507835A/en not_active Application Discontinuation
- 1975-07-01 DE DE19752529292 patent/DE2529292A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| HU173527B (en) | 1979-06-28 |
| ATA498675A (en) | 1977-11-15 |
| NO142910B (en) | 1980-08-04 |
| NO752245L (en) | 1976-01-05 |
| AR207986A1 (en) | 1976-11-22 |
| SE7507365L (en) | 1976-01-02 |
| FR2276820A1 (en) | 1976-01-30 |
| AT344162B (en) | 1978-07-10 |
| CA1051430A (en) | 1979-03-27 |
| CH612189A5 (en) | 1979-07-13 |
| FI751890A7 (en) | 1976-01-02 |
| FI59586C (en) | 1981-09-10 |
| AU8264175A (en) | 1977-01-06 |
| NL7507835A (en) | 1976-01-05 |
| GB1502384A (en) | 1978-03-01 |
| FI59586B (en) | 1981-05-29 |
| DE2529292A1 (en) | 1976-01-22 |
| DK294175A (en) | 1976-01-02 |
| NO142910C (en) | 1980-11-12 |
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