ES439051A1 - Procedure for the obtaining of new derivatives of diazepine. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of new derivatives of diazepine. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES439051A1 ES439051A1 ES439051A ES439051A ES439051A1 ES 439051 A1 ES439051 A1 ES 439051A1 ES 439051 A ES439051 A ES 439051A ES 439051 A ES439051 A ES 439051A ES 439051 A1 ES439051 A1 ES 439051A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- formula
- general formula
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- -1 polymethylenimino Polymers 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedure for obtaining new diazepine derivatives of general formula I **(See formula)** wherein R1 signifies hydrogen or an alkyl group with 1 to 3 carbon atoms, A signifies an alkylene group with 1 to 3 carbon atoms, R2 signifies the hydroxyl group, an aqueous group with 1 to 6 carbon atoms, a group mono- or diaryl-methoxy, a dialkylamino, N-alkyl-aralkylamino or diaralkylamino group, where the alkyl groups contain 1 to 6 and the aralkyl groups 7 to 9 carbon atoms, a polymethylenimino radical with 5 to 7 ring members or a morpholino residue, the cyclic residues of which can be substituted by and including alkyl groups, contain a maximum of 10 carbon atoms and rings B and C can be substituted by halogen up to atomic number 35, trifluoromethyl, alkyl or alkoxy groups with 1 to 6 carbon atoms, and their addition salts with inorganic or organic acids, characterized in that a compound of general formula II **(See formula)** Where R1 has the meaning indicated under formula I and rings B and C may be substituted as indicated therein, it is reacted with a carboxylic acid of general formula III **(See formula)** where R2 has the meaning indicated under formula I for R1, except for the hydroxyl group and A has the meaning indicated under formula A, or a reactive functional derivative thereof, where R2'means a monoarylmethoxy or diarylmethoxy group, while R1 and A have the meaning indicated under formula I and rings B and C may be substituted as indicated therein, it is cleaved to a compound of general formula I, the residue R2 of which is the hydroxyl group, and/or, if desired, a compound obtained of general formula I is converted into an addition salt with an inorganic or organic acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK560071AA DK138854B (en) | 1970-11-23 | 1971-11-15 | Analogous process for the preparation of s-triazolo (4,3-a) (1,4) benzodiazepine derivatives or 5-oxides or salts thereof. |
| CH681972A CH569737A5 (en) | 1972-05-08 | 1972-05-08 | 4,5-dihydro-4h-s-triazolo (4,3-a) (1,4) benzodiazepine - cns depressants, anti-convulsants, anti-aggressives and somatic reflex in |
| DK248772A DK140987B (en) | 1971-11-15 | 1972-05-18 | Analogous process for the preparation of s-triazolo (4,3-a) (1,4) benzodiazepine derivatives or addition salts thereof with inorganic or organic acids. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES439051A1 true ES439051A1 (en) | 1977-02-01 |
Family
ID=27175603
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439051A Expired ES439051A1 (en) | 1971-11-15 | 1975-07-01 | Procedure for the obtaining of new derivatives of diazepine. (Machine-translation by Google Translate, not legally binding) |
| ES439052A Expired ES439052A1 (en) | 1971-11-15 | 1975-07-01 | Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439052A Expired ES439052A1 (en) | 1971-11-15 | 1975-07-01 | Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (4)
| Country | Link |
|---|---|
| DK (1) | DK140987B (en) |
| ES (2) | ES439051A1 (en) |
| PL (2) | PL92116B1 (en) |
| SU (2) | SU578877A3 (en) |
-
1972
- 1972-05-18 DK DK248772A patent/DK140987B/en unknown
-
1973
- 1973-02-27 PL PL18337273A patent/PL92116B1/pl unknown
- 1973-02-27 PL PL18337373A patent/PL92991B1/pl unknown
-
1974
- 1974-07-15 SU SU7402043344A patent/SU578877A3/en active
-
1975
- 1975-07-01 ES ES439051A patent/ES439051A1/en not_active Expired
- 1975-07-01 ES ES439052A patent/ES439052A1/en not_active Expired
- 1975-07-15 SU SU7502043346A patent/SU578004A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| PL92116B1 (en) | 1977-03-31 |
| SU578004A3 (en) | 1977-10-25 |
| SU578877A3 (en) | 1977-10-30 |
| PL92991B1 (en) | 1977-04-30 |
| DK140987B (en) | 1979-12-17 |
| DK140987C (en) | 1980-06-02 |
| ES439052A1 (en) | 1977-04-01 |
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