ES440221A1 - Procedimiento para preparar 3-(alfa-acetonilbencil)-4-hidro-xicumarina microcristalina. - Google Patents

Procedimiento para preparar 3-(alfa-acetonilbencil)-4-hidro-xicumarina microcristalina.

Info

Publication number: ES440221A1
Authority: ES; Spain
Prior art keywords: warfarin; microcrystalline; acetonylbenzyl; alpha; making
Prior art date: 1974-08-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES440221A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Meda Pharmaceuticals Inc

Original Assignee

Carter Wallace Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-08-13

Filing date

1975-08-13

Publication date

1977-03-01

1975-08-13 Application filed by Carter Wallace Inc filed Critical Carter Wallace Inc

1977-03-01 Publication of ES440221A1 publication Critical patent/ES440221A1/es

Status Expired legal-status Critical Current

Links

PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 title abstract 6
229960005080 warfarin Drugs 0.000 title abstract 4
239000000203 mixture Substances 0.000 abstract 2
239000012670 alkaline solution Substances 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
229940127219 anticoagulant drug Drugs 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
230000020477 pH reduction Effects 0.000 abstract 1
239000003128 rodenticide Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
- C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)

ES440221A 1974-08-13 1975-08-13 Procedimiento para preparar 3-(alfa-acetonilbencil)-4-hidro-xicumarina microcristalina. Expired ES440221A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/496,932 US4113744A (en)	1974-08-13	1974-08-13	Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin (warfarin) and methods of making

Publications (1)

Publication Number	Publication Date
ES440221A1 true ES440221A1 (es)	1977-03-01

Family

ID=23974780

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES440221A Expired ES440221A1 (es)	1974-08-13	1975-08-13	Procedimiento para preparar 3-(alfa-acetonilbencil)-4-hidro-xicumarina microcristalina.

Country Status (13)

Country	Link
US (1)	US4113744A (es)
JP (1)	JPS5835967B2 (es)
BE (1)	BE832395A (es)
BR (1)	BR7504996A (es)
CA (1)	CA1077502A (es)
DE (1)	DE2535228A1 (es)
ES (1)	ES440221A1 (es)
FR (1)	FR2281754A1 (es)
GB (1)	GB1513399A (es)
IN (1)	IN141166B (es)
LU (1)	LU73199A1 (es)
NL (1)	NL7509661A (es)
ZA (1)	ZA754795B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5696274A (en) *	1995-12-28	1997-12-09	Hoechst Celanese Corporation	Syntheses based on 2-hydroxyacetophenone
WO1999049931A2 (en) *	1998-03-30	1999-10-07	Sloan-Kettering Institute For Cancer Research	Bismuth-213 generator and uses thereof
US6512005B2 (en)	2001-02-28	2003-01-28	Taro Pharmaceutical Industries, Ltd.	Process for synthesis of pure warfarin acid, warfarin alkali metal salts and corresponding clathrates
US6610862B2 (en)	2001-02-28	2003-08-26	Taro Pharmaceutical Industries Ltd.	Preparation of warfarin sodium from warfarin sodium-2-propanol clathrate by solvent expulsion
CN1505620A (zh) *	2001-02-28	2004-06-16	��ҩ��޹�˾	提纯苄丙酮香豆素酸、苄丙酮香豆素碱金属盐及相应笼形包合物的方法
US6673944B2 (en)	2001-02-28	2004-01-06	Taro Pharmaceutical Industries, Ltd.	Preparation of warfarin sodium from warfarin acid
US20050215625A9 (en) *	2003-01-08	2005-09-29	Nesselroad James M Iii	Combination therapy for anticoagulation
GB0329303D0 (en) *	2003-12-18	2004-01-21	Whelan Ian P	Rodenticide bait system
AU2024300365A1 (en) *	2023-07-22	2026-02-12	Liqmeds Worldwide Limited	A ready-to-use oral liquid formulation of warfarin sodium
CN117169390B (zh) *	2023-10-18	2024-05-03	宁波市疾病预防控制中心(宁波市健康教育与促进中心)	一种测定血液中安妥的方法、试剂盒及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2666064A (en) *	1951-07-10	1954-01-12	S B Penick & Company Inc	Manufacture of 3-(alpha-phenyl-beta-acetylethyl)-4-hydroxycoumarin
US2777859A (en) *	1953-02-05	1957-01-15	Wisconsin Alumni Res Found	Warfarin-alkali metal derivatives and processes of preparing the same
US2752360A (en) *	1953-03-23	1956-06-26	S B Penick & Company Inc	Improvement in the manufacture of 3-substituted 4-hydroxycoumarins
US2932652A (en) *	1957-02-11	1960-04-12	Nicholas M Molnar	3-(1'-(alpha-naphthyl) 3'-oxo-butyl) 4-hydroxy coumarin and salts thereof

1974
- 1974-08-13 US US05/496,932 patent/US4113744A/en not_active Expired - Lifetime
1975
- 1975-07-25 ZA ZA754795A patent/ZA754795B/xx unknown
- 1975-07-31 IN IN1515/CAL/1975A patent/IN141166B/en unknown
- 1975-07-31 CA CA232,784A patent/CA1077502A/en not_active Expired
- 1975-08-05 BR BR7504996A patent/BR7504996A/pt unknown
- 1975-08-07 JP JP50095464A patent/JPS5835967B2/ja not_active Expired
- 1975-08-07 DE DE19752535228 patent/DE2535228A1/de not_active Withdrawn
- 1975-08-12 FR FR7525087A patent/FR2281754A1/fr active Granted
- 1975-08-13 BE BE159171A patent/BE832395A/xx unknown
- 1975-08-13 LU LU73199A patent/LU73199A1/xx unknown
- 1975-08-13 ES ES440221A patent/ES440221A1/es not_active Expired
- 1975-08-13 NL NL7509661A patent/NL7509661A/xx not_active Application Discontinuation
- 1975-08-13 GB GB33672/75A patent/GB1513399A/en not_active Expired

Also Published As

Publication number	Publication date
FR2281754B1 (es)	1978-11-10
ZA754795B (en)	1977-03-30
DE2535228A1 (de)	1976-02-26
JPS5141361A (es)	1976-04-07
GB1513399A (en)	1978-06-07
JPS5835967B2 (ja)	1983-08-05
NL7509661A (nl)	1976-02-17
BR7504996A (pt)	1976-08-31
LU73199A1 (es)	1976-08-13
CA1077502A (en)	1980-05-13
FR2281754A1 (fr)	1976-03-12
IN141166B (es)	1977-01-29
AU8356175A (en)	1977-02-03
US4113744A (en)	1978-09-12
BE832395A (fr)	1976-02-13

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