ES441207A1 - Un procedimiento para la preparacion de nuevos derivados trans de decahidroisoquinoleina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados trans de decahidroisoquinoleina.Info
- Publication number
- ES441207A1 ES441207A1 ES441207A ES441207A ES441207A1 ES 441207 A1 ES441207 A1 ES 441207A1 ES 441207 A ES441207 A ES 441207A ES 441207 A ES441207 A ES 441207A ES 441207 A1 ES441207 A1 ES 441207A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- see formula
- see
- product
- och3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- NENLYAQPNATJSU-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline Chemical class C1NCCC2CCCCC21 NENLYAQPNATJSU-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- NENLYAQPNATJSU-IUCAKERBSA-N (4as,8ar)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline Chemical class C1NCC[C@@H]2CCCC[C@H]21 NENLYAQPNATJSU-IUCAKERBSA-N 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 229940035676 analgesics Drugs 0.000 abstract 2
- 239000000730 antalgic agent Substances 0.000 abstract 2
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- AGEZXYOZHKGVCM-UHFFFAOYSA-N benzyl bromide Chemical compound BrCC1=CC=CC=C1 AGEZXYOZHKGVCM-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- -1 lithium aluminum hydride Chemical compound 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 229910000104 sodium hydride Inorganic materials 0.000 abstract 1
- 239000012312 sodium hydride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50857774A | 1974-09-23 | 1974-09-23 | |
| US59838175A | 1975-07-29 | 1975-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES441207A1 true ES441207A1 (es) | 1977-07-01 |
Family
ID=27056229
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES441207A Expired ES441207A1 (es) | 1974-09-23 | 1975-09-23 | Un procedimiento para la preparacion de nuevos derivados trans de decahidroisoquinoleina. |
| ES456170A Expired ES456170A1 (es) | 1974-09-23 | 1977-02-16 | Un procedimiento para la preparacion de nuevos derivados trans de decahidroisoquinoleina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES456170A Expired ES456170A1 (es) | 1974-09-23 | 1977-02-16 | Un procedimiento para la preparacion de nuevos derivados trans de decahidroisoquinoleina. |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5159876A (da) |
| AR (1) | AR209936A1 (da) |
| AU (1) | AU506970B2 (da) |
| DD (1) | DD122973A5 (da) |
| DE (1) | DE2542152A1 (da) |
| DK (1) | DK424775A (da) |
| ES (2) | ES441207A1 (da) |
| FI (1) | FI752643A7 (da) |
| FR (1) | FR2285131A1 (da) |
| GB (1) | GB1465223A (da) |
| HU (1) | HU174285B (da) |
| IL (1) | IL48148A (da) |
| LU (1) | LU73435A1 (da) |
| NL (1) | NL7511199A (da) |
| NZ (1) | NZ178737A (da) |
| SE (1) | SE7509337L (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6075461A (ja) * | 1983-09-30 | 1985-04-27 | Nippon Steel Chem Co Ltd | Ν−アルキルデカヒドロイソキノリンの製造法 |
| US5939551A (en) * | 1996-05-15 | 1999-08-17 | Toray Industries, Inc. | Process for producing 4a-aryldecahydroisoquinoline derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2351599A1 (de) * | 1972-07-20 | 1974-01-31 | Du Pont | 4a-aryl-trans-decahydrochinoline und verfahren zu ihrer herstellung |
-
1975
- 1975-08-21 SE SE7509337A patent/SE7509337L/xx unknown
- 1975-09-22 NZ NZ178737A patent/NZ178737A/xx unknown
- 1975-09-22 FI FI752643A patent/FI752643A7/fi not_active Application Discontinuation
- 1975-09-22 GB GB3883675A patent/GB1465223A/en not_active Expired
- 1975-09-22 LU LU73435A patent/LU73435A1/xx unknown
- 1975-09-22 HU HU75DU241A patent/HU174285B/hu unknown
- 1975-09-22 DD DD188475A patent/DD122973A5/xx unknown
- 1975-09-22 DE DE19752542152 patent/DE2542152A1/de not_active Withdrawn
- 1975-09-22 AU AU85041/75A patent/AU506970B2/en not_active Expired
- 1975-09-22 FR FR7528988A patent/FR2285131A1/fr active Granted
- 1975-09-22 IL IL48148A patent/IL48148A/xx unknown
- 1975-09-22 DK DK424775A patent/DK424775A/da not_active Application Discontinuation
- 1975-09-23 NL NL7511199A patent/NL7511199A/xx unknown
- 1975-09-23 ES ES441207A patent/ES441207A1/es not_active Expired
- 1975-09-23 JP JP50115442A patent/JPS5159876A/ja active Pending
- 1975-09-23 AR AR260493A patent/AR209936A1/es active
-
1977
- 1977-02-16 ES ES456170A patent/ES456170A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7511199A (nl) | 1976-03-25 |
| LU73435A1 (da) | 1976-08-13 |
| SE7509337L (sv) | 1976-03-24 |
| AU506970B2 (en) | 1980-01-31 |
| ES456170A1 (es) | 1978-05-01 |
| AR209936A1 (es) | 1977-06-15 |
| DK424775A (da) | 1976-03-24 |
| FI752643A7 (da) | 1976-03-24 |
| AU8504175A (en) | 1977-03-31 |
| DD122973A5 (de) | 1976-11-12 |
| FR2285131B1 (da) | 1978-11-10 |
| JPS5159876A (en) | 1976-05-25 |
| HU174285B (hu) | 1979-12-28 |
| IL48148A (en) | 1979-12-30 |
| IL48148A0 (en) | 1975-11-25 |
| FR2285131A1 (fr) | 1976-04-16 |
| DE2542152A1 (de) | 1976-04-01 |
| GB1465223A (en) | 1977-02-23 |
| NZ178737A (en) | 1978-03-06 |
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