ES442142A1 - A PROCEDURE FOR THE PREPARATION OF QUATERNARY SALTS OF D-HOMOSTEROIDS. - Google Patents

A PROCEDURE FOR THE PREPARATION OF QUATERNARY SALTS OF D-HOMOSTEROIDS.

Info

Publication number
ES442142A1
ES442142A1 ES442142A ES442142A ES442142A1 ES 442142 A1 ES442142 A1 ES 442142A1 ES 442142 A ES442142 A ES 442142A ES 442142 A ES442142 A ES 442142A ES 442142 A1 ES442142 A1 ES 442142A1
Authority
ES
Spain
Prior art keywords
group
homosteroids
formula
hydrogen atom
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES442142A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES442142A1 publication Critical patent/ES442142A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A procedure for the preparation of quaternary salts of D-homosteroids, of the general formula **(See formula)** in which R1, R2, R4 and R5 each independently represent a hydrogen atom or a group of C1-10 alkyl or C7-10 aralkyl or R1 and R2 or R4 and R5 together with the N atom to which they are attached they represent a hethocyclic group; R3 represents a hydrogen atom or an acyl group; and R6 represents an oxo group, (beta-H, alpha-OR7) or (alpha-H, B-OR7) where R7 represents a hydrogen atom or an acyl group, with at least one nitrogen atom being present in quaternized form, and of the acid addition salts of monoquaternary salts of D-homosteroids of formula I, the method of which comprises quaternizing one or both of the amine groups of a D-homoesteroid of formula I and, if desired, functionally modifying the group designated with R6, acylate a 3-hydroxylic group and/or convert a mono-quaternary salt obtained into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES442142A 1974-10-29 1975-10-28 A PROCEDURE FOR THE PREPARATION OF QUATERNARY SALTS OF D-HOMOSTEROIDS. Expired ES442142A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1446974A CH602794A5 (en) 1974-10-29 1974-10-29

Publications (1)

Publication Number Publication Date
ES442142A1 true ES442142A1 (en) 1977-04-01

Family

ID=4401103

Family Applications (1)

Application Number Title Priority Date Filing Date
ES442142A Expired ES442142A1 (en) 1974-10-29 1975-10-28 A PROCEDURE FOR THE PREPARATION OF QUATERNARY SALTS OF D-HOMOSTEROIDS.

Country Status (23)

Country Link
JP (1) JPS51125267A (en)
AR (1) AR212436A1 (en)
AT (1) AT349161B (en)
BE (1) BE834925A (en)
CA (1) CA1050009A (en)
CH (1) CH602794A5 (en)
DD (1) DD123332A5 (en)
DE (1) DE2547739A1 (en)
DK (1) DK135316B (en)
ES (1) ES442142A1 (en)
FI (1) FI53711C (en)
FR (1) FR2289175A1 (en)
GB (1) GB1498239A (en)
HU (1) HU174161B (en)
IE (1) IE42058B1 (en)
IL (1) IL48219A (en)
LU (1) LU73655A1 (en)
NL (1) NL7512661A (en)
NO (1) NO139736C (en)
NZ (1) NZ178817A (en)
PL (1) PL100305B1 (en)
SE (1) SE413248B (en)
ZA (1) ZA756169B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2362648A (en) * 2000-05-23 2001-11-28 Univerzita Palackeho V Olomouc Triterpenoid derivatives
MXPA04006953A (en) 2002-01-18 2005-06-20 Univ Minnesota Triterpene quaternary salts as biologically active surfactants.

Also Published As

Publication number Publication date
NO753616L (en) 1976-04-30
FI53711B (en) 1978-03-31
ZA756169B (en) 1976-09-29
IE42058B1 (en) 1980-05-21
CA1050009A (en) 1979-03-06
CH602794A5 (en) 1978-08-15
FI53711C (en) 1978-07-10
HU174161B (en) 1979-11-28
SE7512006L (en) 1976-04-30
BE834925A (en) 1976-04-28
NL7512661A (en) 1976-05-04
DK135316C (en) 1977-08-22
DE2547739A1 (en) 1976-05-06
NO139736B (en) 1979-01-22
DK135316B (en) 1977-04-04
IL48219A (en) 1979-01-31
SE413248B (en) 1980-05-12
IE42058L (en) 1976-04-29
AU8541875A (en) 1977-04-07
ATA819375A (en) 1978-08-15
GB1498239A (en) 1978-01-18
DK485975A (en) 1976-04-30
IL48219A0 (en) 1975-11-25
NO139736C (en) 1979-05-09
AT349161B (en) 1979-03-26
FR2289175B1 (en) 1980-05-30
LU73655A1 (en) 1977-05-31
PL100305B1 (en) 1978-09-30
NZ178817A (en) 1978-06-02
AR212436A1 (en) 1978-07-14
FI752825A7 (en) 1976-04-30
FR2289175A1 (en) 1976-05-28
JPS51125267A (en) 1976-11-01
DD123332A5 (en) 1976-12-12

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