ES443766A1 - Un procedimiento de preparacion de derivados del triptofa- no. - Google Patents
Un procedimiento de preparacion de derivados del triptofa- no.Info
- Publication number
- ES443766A1 ES443766A1 ES443766A ES443766A ES443766A1 ES 443766 A1 ES443766 A1 ES 443766A1 ES 443766 A ES443766 A ES 443766A ES 443766 A ES443766 A ES 443766A ES 443766 A1 ES443766 A1 ES 443766A1
- Authority
- ES
- Spain
- Prior art keywords
- nervous system
- central nervous
- increased effect
- tryptophan derivatives
- denotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical class C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title abstract 2
- 210000003169 central nervous system Anatomy 0.000 title abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- -1 nitrogenous organic bases Chemical class 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7442505A FR2295746A1 (fr) | 1974-12-23 | 1974-12-23 | Nouveaux derives du tryptophane a activite nerveuse centrale renforcee |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES443766A1 true ES443766A1 (es) | 1977-04-16 |
Family
ID=9146520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES443766A Expired ES443766A1 (es) | 1974-12-23 | 1975-12-22 | Un procedimiento de preparacion de derivados del triptofa- no. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4299838A (es) |
| BE (1) | BE836954A (es) |
| DE (1) | DE2557497C2 (es) |
| ES (1) | ES443766A1 (es) |
| FR (1) | FR2295746A1 (es) |
| GB (1) | GB1529340A (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04506967A (ja) * | 1989-07-27 | 1992-12-03 | ジー．ディー．サール アンド カンパニー | 高血圧症治療用腎選択性生成物 |
| US5939076A (en) * | 1997-11-12 | 1999-08-17 | Allocca Techical, Inc. | Composition and method for treating or alleviating migraine headaches |
| WO1999052539A1 (en) | 1998-04-10 | 1999-10-21 | Mayo Foundation For Medical Education And Research | Neo-tryptophan |
| US7087575B2 (en) * | 2002-07-18 | 2006-08-08 | Mayo Foundation For Medical Education And Research | Treating the effect of nicotine |
| DK1549333T3 (da) | 2002-09-20 | 2012-01-16 | Univ Pennsylvania | Compstatinanaloge med forbedret aktivitet |
| US7399324B2 (en) * | 2004-01-29 | 2008-07-15 | Camovision Of Georgia, Llc | Active agent delivery device |
| CA2625206C (en) | 2005-10-08 | 2021-12-07 | Potentia Pharmaceuticals, Inc. | Compstatin and analogs thereof for eye disorders |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| CN106188239B (zh) | 2005-11-28 | 2020-01-07 | 宾夕法尼亚州大学理事会 | 有效的坎普他汀类似物 |
| WO2007100718A2 (en) * | 2006-02-24 | 2007-09-07 | Denise Barbut | Neurotensin receptor agonists and opioid receptor agonists |
| WO2007114948A2 (en) * | 2006-04-04 | 2007-10-11 | The Brigham And Women's Hospital, Inc. | Methods and compositions for inhibiting cell death |
| AU2008214359B2 (en) | 2007-02-05 | 2014-01-16 | Apellis Pharmaceuticals, Inc. | Local complement inhibition for treatment of complement-mediated disorders |
| CN102458438A (zh) | 2009-05-01 | 2012-05-16 | 宾夕法尼亚州大学理事会 | 具有肽骨架和c-末端修饰的经修饰补体抑素 |
| CA2813049A1 (en) | 2010-09-23 | 2012-03-29 | The Trustees Of The University Of Pennsylvania | Modified compstatin with improved stability and binding properties |
| CA2835627C (en) | 2011-05-11 | 2023-01-10 | Apellis Pharmaceuticals, Inc. | Cell-reactive, long-acting, or targeted compstatin analogs and uses thereof |
| EP2723361B1 (en) | 2011-06-22 | 2019-10-30 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
| CA2847862C (en) | 2011-09-07 | 2021-01-12 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with improved pharmacokinetic properties |
| EP3929206A1 (en) | 2012-11-15 | 2021-12-29 | Apellis Pharmaceuticals, Inc. | Long-acting compstatin analogs and related compositions and methods |
| US10308687B2 (en) | 2013-03-15 | 2019-06-04 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
| WO2015142701A1 (en) | 2014-03-17 | 2015-09-24 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with improved potency and pharmacokinetic properties |
| CA3287719A1 (en) | 2015-10-07 | 2026-03-02 | Apellis Pharmaceuticals, Inc. | Use of long-acting compstatin analog for treating a complement-mediated disorder |
| CN116059313A (zh) | 2017-04-07 | 2023-05-05 | 阿佩利斯制药有限公司 | 给药方案以及相关组合物和方法 |
| KR20240167712A (ko) | 2017-12-15 | 2024-11-27 | 아펠리스 파마슈티컬스 인코포레이티드 | 투여 요법 및 관련 조성물 및 방법 |
| WO2019195712A2 (en) | 2018-04-06 | 2019-10-10 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with increased solubility and improved pharmacokinetic properties |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2865928A (en) * | 1956-08-03 | 1958-12-23 | Du Pont | Resolution of n-acyl-dl-tryptophans |
| GB873777A (en) * | 1959-01-26 | 1961-07-26 | Upjohn Co | 5-hydroxy-ª--alkyltryptophans |
| BE791909A (fr) * | 1971-11-24 | 1973-05-24 | Beecham Group Ltd | Compositions pharmaceutiques contenant du lithium et du tryptophane |
-
1974
- 1974-12-23 FR FR7442505A patent/FR2295746A1/fr active Granted
-
1975
- 1975-12-15 GB GB51324/75A patent/GB1529340A/en not_active Expired
- 1975-12-19 DE DE2557497A patent/DE2557497C2/de not_active Expired
- 1975-12-22 BE BE163017A patent/BE836954A/xx not_active IP Right Cessation
- 1975-12-22 ES ES443766A patent/ES443766A1/es not_active Expired
-
1978
- 1978-02-17 US US05/878,811 patent/US4299838A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2295746B1 (es) | 1978-08-18 |
| US4299838A (en) | 1981-11-10 |
| DE2557497C2 (de) | 1983-11-03 |
| GB1529340A (en) | 1978-10-18 |
| BE836954A (fr) | 1976-04-16 |
| DE2557497A1 (de) | 1976-06-24 |
| FR2295746A1 (fr) | 1976-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980202 |