ES443790A1 - A PROCEDURE FOR THE PREPARATION OF BENZYL-PYRIMIDINE DERIVATIVES. - Google Patents

A PROCEDURE FOR THE PREPARATION OF BENZYL-PYRIMIDINE DERIVATIVES.

Info

Publication number
ES443790A1
ES443790A1 ES443790A ES443790A ES443790A1 ES 443790 A1 ES443790 A1 ES 443790A1 ES 443790 A ES443790 A ES 443790A ES 443790 A ES443790 A ES 443790A ES 443790 A1 ES443790 A1 ES 443790A1
Authority
ES
Spain
Prior art keywords
amino
groups
benzyl
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES443790A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES443790A1 publication Critical patent/ES443790A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)

Abstract

Compounds of the formula < IMAGE > in which R<1> represents amino or -NHR<3> R<2> represents amino, pyrrolo, pyrrolidino, piperidino, -NHR<3> or -N(R<3>)2 R<3> represents C1-4-alkyl or C1-4-alkenyl and Z represents hydrogen, chlorine, bromine, pyrrolo, pyrrolidino, piperidino, morpholino, R<3>, OR<3> or -N(R<3>)2, are prepared by hydrolysis of corresponding compounds whose amino groups in the pyrimidine ring and/or whose substituents R<1> and R<2> are present in the form of groups which can be hydrolysed to amino and/or R<3>HN groups. The compounds are distinguished by antibacterial activity or a synergistic effect in combination with sulphonamides and good tolerability.
ES443790A 1974-12-24 1975-12-23 A PROCEDURE FOR THE PREPARATION OF BENZYL-PYRIMIDINE DERIVATIVES. Expired ES443790A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1728774A CH605828A5 (en) 1974-12-24 1974-12-24

Publications (1)

Publication Number Publication Date
ES443790A1 true ES443790A1 (en) 1977-12-16

Family

ID=4424233

Family Applications (1)

Application Number Title Priority Date Filing Date
ES443790A Expired ES443790A1 (en) 1974-12-24 1975-12-23 A PROCEDURE FOR THE PREPARATION OF BENZYL-PYRIMIDINE DERIVATIVES.

Country Status (25)

Country Link
JP (1) JPS5191273A (en)
AT (1) AT344704B (en)
AU (1) AU500102B2 (en)
BE (1) BE836996A (en)
BR (1) BR7508534A (en)
CA (1) CA1059127A (en)
CH (2) CH605828A5 (en)
CU (1) CU34406A (en)
DD (1) DD123603A5 (en)
DE (1) DE2558150A1 (en)
DK (1) DK137797B (en)
ES (1) ES443790A1 (en)
FI (1) FI753312A7 (en)
FR (1) FR2295750A1 (en)
GB (1) GB1492140A (en)
HU (1) HU174324B (en)
IL (1) IL48416A (en)
LU (1) LU73971A1 (en)
NL (1) NL7514269A (en)
NO (1) NO141408C (en)
PH (1) PH12314A (en)
PL (1) PL101046B1 (en)
SE (1) SE417607B (en)
SU (1) SU612629A3 (en)
ZA (1) ZA756964B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR71725B (en) * 1977-11-10 1983-06-22 Hoffmann La Roche
NZ598262A (en) 2009-08-17 2014-05-30 Sloan Kettering Inst Cancer Heat shock protein binding compounds, compositions, and methods for making and using same
EA201692155A1 (en) 2014-05-13 2017-04-28 Мемориал Слоун-Кеттеринг Кэнсэ Сентр Hsp70 modulators and methods for their production and use
CN120081720A (en) * 2025-02-18 2025-06-03 天津汇仁恒通科技有限公司 A method for preparing divinyl aromatic compounds

Also Published As

Publication number Publication date
PH12314A (en) 1979-01-16
JPS5191273A (en) 1976-08-10
FI753312A7 (en) 1976-06-25
CH617191A5 (en) 1980-05-14
IL48416A (en) 1980-02-29
CU34406A (en) 1978-09-08
HU174324B (en) 1979-12-28
AT344704B (en) 1978-08-10
NO141408B (en) 1979-11-26
NO141408C (en) 1980-03-05
IL48416A0 (en) 1976-01-30
FR2295750B1 (en) 1980-06-20
DE2558150A1 (en) 1976-07-01
PL101046B1 (en) 1978-11-30
AU500102B2 (en) 1979-05-10
DK589675A (en) 1976-06-25
SE7514642L (en) 1976-06-28
LU73971A1 (en) 1977-07-01
NL7514269A (en) 1976-06-28
GB1492140A (en) 1977-11-16
BR7508534A (en) 1976-12-21
NO754372L (en) 1976-06-25
SE417607B (en) 1981-03-30
ATA975975A (en) 1977-12-15
SU612629A3 (en) 1978-06-25
AU8643375A (en) 1977-05-12
BE836996A (en) 1976-06-23
ZA756964B (en) 1976-10-27
DD123603A5 (en) 1977-01-05
CH605828A5 (en) 1978-10-13
DK137797B (en) 1978-05-08
CA1059127A (en) 1979-07-24
FR2295750A1 (en) 1976-07-23
DK137797C (en) 1978-10-16

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