ES449557A1 - Procedure for preparation of polymethylene-4, 5 pirazoles. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for preparation of polymethylene-4, 5 pirazoles. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES449557A1 ES449557A1 ES449557A ES449557A ES449557A1 ES 449557 A1 ES449557 A1 ES 449557A1 ES 449557 A ES449557 A ES 449557A ES 449557 A ES449557 A ES 449557A ES 449557 A1 ES449557 A1 ES 449557A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- group
- polymethylene
- translation
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
- -1 H) and (H Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000001351 cycling effect Effects 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
- C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for the preparation of polymethylene-4,5-pyrazoles, which correspond to the following general formula: **(See formula)** in which: - R1 represents a hydrogen atom, an alkyl group comprising 1 to 4 carbon atoms, or a phenyl nucleus substituted by one or more halogen atoms or by two nitro groups, - R2 represents an alkyl group comprising from 1 to 4 carbon atoms, a cyclohexane group, a phenyl nucleus optionally substituted by an alkyl group comprising a maximum of 4 carbon atoms, a methoxy group or a halogen atom or a group benzyl, - R3 represents a hydrogen atom or a methyl group, and - n is equal to 3 or 4, however, the set (R1, R2, R3) cannot take the values (H, phenyl, H) and (H, methyl, H) when n = 4, characterized in that it consists of cycling a β-diketone that responds to the general formula (II): **(See formula)** in which n and R2 have the same meaning as in formula (I), due to the action of a hydrazine hydrate that responds to general formula (III): R1NH - NH2 H2O where R1 has the same meaning as in formula (I). (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7520888A FR2315924A1 (en) | 1975-07-03 | 1975-07-03 | Analgesic and antiinflammatory polymethylene pyrazole derivs. - prepd. by cyclizing 2-acyl cyclic ketones with hydrazine derivs. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES449557A1 true ES449557A1 (en) | 1977-08-01 |
Family
ID=9157451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES449557A Expired ES449557A1 (en) | 1975-07-03 | 1976-07-03 | Procedure for preparation of polymethylene-4, 5 pirazoles. (Machine-translation by Google Translate, not legally binding) |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE2630015C3 (en) |
| ES (1) | ES449557A1 (en) |
| FR (1) | FR2315924A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0226624A1 (en) * | 1985-06-14 | 1987-07-01 | The Upjohn Company | Cyclopentapyrazole and tetrahydroindazole compounds |
| IT1287174B1 (en) * | 1996-11-15 | 1998-08-04 | Angelini Ricerche Spa | PHARMACOLOGICALLY ACTIVE DIARYL-CYCLOMETHYLENPYRAZOLES, PROCEDURE FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM |
| US6083969A (en) * | 1999-10-20 | 2000-07-04 | Ortho-Mcneil Pharaceutical, Inc. | 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as selective inhibitors of cyclooxygenase-2 and antiinflammatory agents |
| RU2485105C1 (en) * | 2012-03-28 | 2013-06-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" | 3-(3,4-dimethoxyphenyl)-4,5,6,7-tetrahydroindazole hydrochloride, analgesic and antimicrobial agent |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1948793A1 (en) * | 1969-09-26 | 1971-04-01 | Rhein Chemie Rheinau Gmbh | Process for the preparation of 4,5,6,7-tetrahydroindazoles |
-
1975
- 1975-07-03 FR FR7520888A patent/FR2315924A1/en active Granted
-
1976
- 1976-07-03 DE DE19762630015 patent/DE2630015C3/en not_active Expired
- 1976-07-03 ES ES449557A patent/ES449557A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2630015B2 (en) | 1980-10-16 |
| DE2630015A1 (en) | 1977-01-27 |
| FR2315924A1 (en) | 1977-01-28 |
| FR2315924B1 (en) | 1978-10-06 |
| DE2630015C3 (en) | 1981-07-30 |
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