ES449740A1 - 1-(benzazolylalkyl)piperidine derivatives - Google Patents
1-(benzazolylalkyl)piperidine derivativesInfo
- Publication number
- ES449740A1 ES449740A1 ES449740A ES449740A ES449740A1 ES 449740 A1 ES449740 A1 ES 449740A1 ES 449740 A ES449740 A ES 449740A ES 449740 A ES449740 A ES 449740A ES 449740 A1 ES449740 A1 ES 449740A1
- Authority
- ES
- Spain
- Prior art keywords
- benzazolylalkyl
- formula
- piperidine derivatives
- salts
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000007126 N-alkylation reaction Methods 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000008673 vomiting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1-(Benzazolylalkyl)piperidine derivatives of formula I < IMAGE > and their salts are prepared by subjecting an amine of formula < IMAGE > to N-alkylation to introduce the corresponding substituted alkyl radical. In the compounds of formula I, the substituents have the meanings given in Patent Claim 1. These compounds and their salts have a spasmolytic action and they are in particular used in agents to prevent vomiting.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59779375A | 1975-07-21 | 1975-07-21 | |
| US05/687,139 US4066772A (en) | 1975-07-21 | 1976-05-17 | 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds |
| KR7601697A KR810000334B1 (en) | 1975-07-21 | 1976-07-12 | Process for preparation 1-(benzazolylalkyl)-piperidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES449740A1 true ES449740A1 (en) | 1978-02-16 |
Family
ID=27348142
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES449740A Expired ES449740A1 (en) | 1975-07-21 | 1976-07-09 | 1-(benzazolylalkyl)piperidine derivatives |
| ES461630A Expired ES461630A1 (en) | 1975-07-21 | 1977-08-16 | A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1- (BENZAZOLYLALKYL) PIPERIDINE. |
| ES461631A Expired ES461631A1 (en) | 1975-07-21 | 1977-08-16 | A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1- (BENZAZOLYLALKYL) PIPERIDINE. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES461630A Expired ES461630A1 (en) | 1975-07-21 | 1977-08-16 | A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1- (BENZAZOLYLALKYL) PIPERIDINE. |
| ES461631A Expired ES461631A1 (en) | 1975-07-21 | 1977-08-16 | A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1- (BENZAZOLYLALKYL) PIPERIDINE. |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS5217475A (en) |
| AT (1) | AT364358B (en) |
| AU (1) | AU511027B2 (en) |
| BG (1) | BG26526A3 (en) |
| CA (1) | CA1085852A (en) |
| CH (1) | CH623820A5 (en) |
| CS (1) | CS202550B2 (en) |
| DE (1) | DE2632870A1 (en) |
| DK (1) | DK154950C (en) |
| ES (3) | ES449740A1 (en) |
| FI (1) | FI62667C (en) |
| GB (1) | GB1542514A (en) |
| HK (1) | HK14180A (en) |
| IE (1) | IE43496B1 (en) |
| IT (1) | IT1062614B (en) |
| KE (1) | KE3215A (en) |
| LU (1) | LU75354A1 (en) |
| MY (1) | MY8100017A (en) |
| NL (1) | NL187442C (en) |
| NZ (1) | NZ181256A (en) |
| PH (1) | PH13710A (en) |
| PT (1) | PT65387B (en) |
| RO (1) | RO70566A (en) |
| SE (2) | SE426490B (en) |
| YU (1) | YU39969B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4501749A (en) * | 1983-10-31 | 1985-02-26 | Merck & Co., Inc. | Peripherally selective dopamine antagonists in the treatment of ocular hypertension |
| JPS6248684A (en) * | 1985-08-26 | 1987-03-03 | Sumitomo Chem Co Ltd | Novel iodobutyrophenone derivative and production thereof |
| JPS62251313A (en) * | 1986-04-25 | 1987-11-02 | 信越ポリマー株式会社 | Bundling device |
| FR2723091B1 (en) * | 1994-07-29 | 1996-11-08 | Esteve Labor Dr | TETRAHYDROPYRIDINE- (6,4-HYDROXYPIPERIDINE) ALKYLAZOLES |
| US6355659B1 (en) | 1994-07-29 | 2002-03-12 | Laboratorios Del Dr. Esteve, S.A. | 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same |
| RU2192848C1 (en) * | 2001-10-30 | 2002-11-20 | Закрытое акционерное общество "ВЕРОФАРМ" | Antiemetic remedy |
| PA8603801A1 (en) | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | DERIVATIVES OF QUINAZOLINE |
| RU2268047C2 (en) * | 2003-12-15 | 2006-01-20 | Закрытое акционерное общество "Фармацевтическое предприятие "Оболенское" | Medicinal formulation possessing anti-vomiting effect and method for its preparing |
| DE602004012891T2 (en) | 2003-12-18 | 2009-04-09 | Janssen Pharmaceutica N.V. | PYRIDO AND PYRIMIDOPYRIMIDIN DERIVATIVES AS ANTI-PROLIFERATIVE AGENTS |
| NI200700147A (en) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | QUINAZOLINE DERIVATIVES KINE INHIBITORS TARGETING MULTIP |
| DK2044084T3 (en) | 2006-07-13 | 2016-05-09 | Janssen Pharmaceutica Nv | MTKI-quinazoline derivatives |
| EP1997805A1 (en) * | 2007-06-01 | 2008-12-03 | Commissariat à l'Energie Atomique | Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans |
| DK2185562T3 (en) | 2007-07-27 | 2016-02-22 | Janssen Pharmaceutica Nv | PYRROLOPYRIMIDINES SUITABLE FOR TREATING PROLIFERATIVE DISEASES |
| KR20140139125A (en) | 2007-08-31 | 2014-12-04 | 퍼듀 퍼머 엘피 | Substituted-quinoxaline-type piperidine compounds and the uses thereof |
| WO2014102594A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
| EP3411031B1 (en) * | 2016-02-04 | 2024-07-24 | CinDome Pharma, Inc. | Deuterated domperidone compositions and methods for therapy of disorders |
| KR20240125702A (en) | 2017-06-30 | 2024-08-19 | 신돔 파마, 인크. | Deuterated domperidone compositions, methods, and preparation |
| US12478612B2 (en) | 2017-06-30 | 2025-11-25 | Cindome Pharma, Inc. | Deuterated domperidone compositions, methods, and preparation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE633495A (en) * | 1962-06-13 | |||
| BE633914A (en) * | 1962-06-22 | |||
| US3629267A (en) * | 1968-10-28 | 1971-12-21 | Smith Kline French Lab | Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione |
| AU4698672A (en) * | 1972-09-22 | 1972-11-09 | Ciba-Geigy Ag | Azacycloaliphatic compounds, process for their manufacture and compositions containing them |
| FR2218100A1 (en) * | 1973-02-20 | 1974-09-13 | Janssen Pharmaceutica Nv | Neuroleptic tricyclic derivs. - of benzimidazolinones and triazaspiro-4,5-decan-4-ones |
| US3989707A (en) * | 1974-06-21 | 1976-11-02 | Janssen Pharmaceutica N.V. | Benzimidazolinone derivatives |
-
1976
- 1976-06-23 NZ NZ181256A patent/NZ181256A/en unknown
- 1976-06-30 GB GB7627242A patent/GB1542514A/en not_active Expired
- 1976-07-07 RO RO7686860A patent/RO70566A/en unknown
- 1976-07-07 CA CA256,450A patent/CA1085852A/en not_active Expired
- 1976-07-08 PH PH18663A patent/PH13710A/en unknown
- 1976-07-09 LU LU75354A patent/LU75354A1/xx unknown
- 1976-07-09 ES ES449740A patent/ES449740A1/en not_active Expired
- 1976-07-16 AU AU15964/76A patent/AU511027B2/en not_active Expired
- 1976-07-16 CS CS764688A patent/CS202550B2/en unknown
- 1976-07-19 IT IT50499/76A patent/IT1062614B/en active
- 1976-07-19 JP JP51085216A patent/JPS5217475A/en active Granted
- 1976-07-20 FI FI762086A patent/FI62667C/en not_active IP Right Cessation
- 1976-07-20 CH CH929176A patent/CH623820A5/en not_active IP Right Cessation
- 1976-07-20 BG BG033791A patent/BG26526A3/en unknown
- 1976-07-20 AT AT0534776A patent/AT364358B/en not_active IP Right Cessation
- 1976-07-20 IE IE1602/76A patent/IE43496B1/en not_active IP Right Cessation
- 1976-07-20 NL NLAANVRAGE7608023,A patent/NL187442C/en not_active IP Right Cessation
- 1976-07-20 PT PT65387A patent/PT65387B/en unknown
- 1976-07-20 DK DK327576A patent/DK154950C/en not_active IP Right Cessation
- 1976-07-20 SE SE7608265A patent/SE426490B/en not_active IP Right Cessation
- 1976-07-21 DE DE19762632870 patent/DE2632870A1/en active Granted
- 1976-07-21 YU YU1794/76A patent/YU39969B/en unknown
-
1977
- 1977-08-16 ES ES461630A patent/ES461630A1/en not_active Expired
- 1977-08-16 ES ES461631A patent/ES461631A1/en not_active Expired
-
1980
- 1980-03-20 HK HK141/80A patent/HK14180A/en unknown
- 1980-12-11 SE SE8008713A patent/SE435621B/en not_active IP Right Cessation
-
1981
- 1981-12-30 MY MY17/81A patent/MY8100017A/en unknown
-
1982
- 1982-05-21 KE KE3215A patent/KE3215A/en unknown
Also Published As
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