ES450060A1 - 33nitroo44hydroxyyquinolinee2*1h* ons - Google Patents
33nitroo44hydroxyyquinolinee2*1h* onsInfo
- Publication number
- ES450060A1 ES450060A1 ES450060A ES450060A ES450060A1 ES 450060 A1 ES450060 A1 ES 450060A1 ES 450060 A ES450060 A ES 450060A ES 450060 A ES450060 A ES 450060A ES 450060 A1 ES450060 A1 ES 450060A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- formula
- trifluoromethyl
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- SHZUGBYEPDMAPC-UHFFFAOYSA-N 4-hydroxy-3-nitro-1h-quinolin-2-one Chemical class C1=CC=C2C(=O)C([N+]([O-])=O)=C(O)NC2=C1 SHZUGBYEPDMAPC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- VYFOAVADNIHPTR-UHFFFAOYSA-N isatoic anhydride Chemical compound NC1=CC=CC=C1CO VYFOAVADNIHPTR-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
A procedure for the preparation, of new 3-nitro-4-hydroxy-quinolin-2 (1H) -ones of formula I: **(See formula)** where R ° is hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 3 to 6 carbon atoms, alkynyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloalkylalkyl where the cycloalkyl is of 3 to 6 carbon atoms and the alkyl portion is 1 or 2 carbon atoms, or **(See formula)** wherein Y and Y', independently, are hydrogen, fluorine, chlorine, bromine, C1-C3-alkyl, C1-C3-alkoxy, or trifluoromethyl, and n is O or 1, and R and R'independently are hydrogen, fluorine, chlorine, bromine, C1 -C4 -alkyl, C1 -C4 -alkoxy, nitro or trifluoromethyl, with the proviso that only one of the symbols R and R'may be from the group consisting of nitro and trifluoromethyl, with the additional condition that the unsaturation in any alkenyl or alkynyl group is not in the alpha carbon atom, the procedure of which is to react in an inert organic solvent, and to a temperature between approximately 202 and 200ºC, an isatoic anhydride of formula II: **(See formula)** where R °, R'and R have the previously indicated meanings, with the product of the treatment of a compound of formula III: R''OOC-CH2 - NO2 III where R'' is alkyl of 1 to 5 carbon atoms, with a strong base. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59853975A | 1975-07-23 | 1975-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES450060A1 true ES450060A1 (en) | 1977-12-01 |
Family
ID=24395967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES450060A Expired ES450060A1 (en) | 1975-07-23 | 1976-07-22 | 33nitroo44hydroxyyquinolinee2*1h* ons |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5225781A (en) |
| AU (1) | AU1620976A (en) |
| BE (1) | BE844414A (en) |
| DD (1) | DD126769A5 (en) |
| DE (1) | DE2631317A1 (en) |
| DK (1) | DK319276A (en) |
| ES (1) | ES450060A1 (en) |
| FI (1) | FI762046A7 (en) |
| FR (1) | FR2318633A1 (en) |
| IL (1) | IL50090A0 (en) |
| NL (1) | NL7607968A (en) |
| NO (1) | NO762489L (en) |
| NZ (1) | NZ181532A (en) |
| PT (1) | PT65391B (en) |
| SE (1) | SE7608151L (en) |
| YU (1) | YU181176A (en) |
| ZA (1) | ZA764449B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54130587A (en) * | 1978-03-30 | 1979-10-09 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| IE52656B1 (en) * | 1981-04-07 | 1988-01-06 | Shell Int Research | Closure device |
| JPS60101445U (en) * | 1983-12-17 | 1985-07-10 | 紀伊産業株式会社 | sealed container |
| JPH0621181B2 (en) * | 1987-01-12 | 1994-03-23 | テルモ株式会社 | Method for producing hydrophilic polyvinylidene fluoride porous membrane |
| JPH0644827Y2 (en) * | 1988-09-20 | 1994-11-16 | エヌオーケー株式会社 | cap |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1770482A1 (en) * | 1968-05-22 | 1971-11-11 | Basf Ag | Process for the preparation of 2,4-dioxyquinolines |
| DE2354145A1 (en) * | 1972-11-02 | 1974-05-16 | Sandoz Ag | CHINAZOLIN-2 (LH) -ONE AND METHOD FOR MANUFACTURING IT |
| GB1453863A (en) * | 1973-05-19 | 1976-10-27 | Beecham Group Ltd | Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity |
-
1976
- 1976-07-12 DE DE19762631317 patent/DE2631317A1/en active Pending
- 1976-07-14 DK DK319276A patent/DK319276A/en unknown
- 1976-07-14 FI FI762046A patent/FI762046A7/fi not_active Application Discontinuation
- 1976-07-15 NO NO762489A patent/NO762489L/no unknown
- 1976-07-16 SE SE7608151A patent/SE7608151L/en unknown
- 1976-07-19 NL NL7607968A patent/NL7607968A/en unknown
- 1976-07-21 NZ NZ181532A patent/NZ181532A/en unknown
- 1976-07-21 PT PT65391A patent/PT65391B/en unknown
- 1976-07-21 JP JP51086079A patent/JPS5225781A/en active Pending
- 1976-07-21 DD DD193994A patent/DD126769A5/xx unknown
- 1976-07-21 IL IL50090A patent/IL50090A0/en unknown
- 1976-07-22 ES ES450060A patent/ES450060A1/en not_active Expired
- 1976-07-22 YU YU01811/76A patent/YU181176A/en unknown
- 1976-07-22 BE BE169152A patent/BE844414A/en unknown
- 1976-07-23 ZA ZA00764449A patent/ZA764449B/en unknown
- 1976-07-23 FR FR7622494A patent/FR2318633A1/en active Granted
- 1976-07-23 AU AU16209/76A patent/AU1620976A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK319276A (en) | 1977-01-24 |
| ZA764449B (en) | 1978-03-29 |
| FR2318633B1 (en) | 1978-12-22 |
| FR2318633A1 (en) | 1977-02-18 |
| JPS5225781A (en) | 1977-02-25 |
| SE7608151L (en) | 1977-01-24 |
| BE844414A (en) | 1977-01-24 |
| NZ181532A (en) | 1978-07-10 |
| FI762046A7 (en) | 1977-01-24 |
| DD126769A5 (en) | 1977-08-10 |
| PT65391B (en) | 1978-04-05 |
| NO762489L (en) | 1977-01-25 |
| IL50090A0 (en) | 1976-09-30 |
| NL7607968A (en) | 1977-01-25 |
| PT65391A (en) | 1976-08-01 |
| AU1620976A (en) | 1978-01-26 |
| YU181176A (en) | 1982-05-31 |
| DE2631317A1 (en) | 1977-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES284924A1 (en) | Procedure for the preparation of agents to combat the growth of unwanted plants (Machine-translation by Google Translate, not legally binding) | |
| ES463200A1 (en) | Agricultural fungicidal compositions containing 6-(substituted phenyl)-pyridazinones and said pyridazinones | |
| ES380041A1 (en) | Tricyclic quinazolinones | |
| ES450060A1 (en) | 33nitroo44hydroxyyquinolinee2*1h* ons | |
| GB1111988A (en) | 2',3'-dideoxyriboside-2',3'-olefins | |
| ES317861A1 (en) | A procedure for the preparation of indian compounds. (Machine-translation by Google Translate, not legally binding) | |
| ES451903A1 (en) | Diphenylamines | |
| ES290435A1 (en) | Centrifugal moulding machines | |
| ES449531A1 (en) | Synthesis of 3,5-diphenyl-4(1h)-pyridazinones | |
| ES386022A1 (en) | Methylenedioxy quinazoline derivatives | |
| ES451451A1 (en) | Carbamoylacetamide derivatives | |
| ES417337A2 (en) | Derivatives of phenylaminopyridine | |
| ES444439A1 (en) | PROCEDURE FOR OBTAINING CARBONATES OF CETOOXIMA. | |
| ES282449A1 (en) | Procedure for preparing new oxazine derivatives (Machine-translation by Google Translate, not legally binding) | |
| ES389161A1 (en) | Formamidine derivatives and the composition containing same | |
| ES291672A1 (en) | Procedure for obtaining benzanilide derivatives (Machine-translation by Google Translate, not legally binding) | |
| ES387034A1 (en) | Procedure for the obtaining of quinazolinones. (Machine-translation by Google Translate, not legally binding) | |
| ES422953A1 (en) | Haloacetanilides for influencing plant growth | |
| ES439537A1 (en) | Substituted biscyclohexanols | |
| ES447185A1 (en) | Process for the production of iminopyrrolinones | |
| ES439006A1 (en) | Procedure for the obtaining of new derivatives of 2-arilamino-2-imidazoline. (Machine-translation by Google Translate, not legally binding) | |
| ES375923A1 (en) | PROCEDURE FOR OBTAINING TRICICLO-OXA (TIA) ZOLICOS DERIVATIVES. | |
| ES409379A1 (en) | Procedure for the obtaining of salicilanilidas. (Machine-translation by Google Translate, not legally binding) | |
| ES376839A1 (en) | Production of adiponitrile | |
| ES378961A1 (en) | Herbicide |