ES450109A1 - Phenothiazine derivatives and their preparation - Google Patents
Phenothiazine derivatives and their preparationInfo
- Publication number
- ES450109A1 ES450109A1 ES450109A ES450109A ES450109A1 ES 450109 A1 ES450109 A1 ES 450109A1 ES 450109 A ES450109 A ES 450109A ES 450109 A ES450109 A ES 450109A ES 450109 A1 ES450109 A1 ES 450109A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- phenothiazine derivatives
- preparation
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000001484 phenothiazinyl group Chemical class C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 title abstract 2
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- UANSQQFYKHHDJM-KRWDZBQOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]naphthalene-1-carboxamide Chemical compound C1=CC=C2C(C(N[C@@H]3C4CCN(CC4)C3)=O)=CC=CC2=C1 UANSQQFYKHHDJM-KRWDZBQOSA-N 0.000 abstract 1
- 239000003880 polar aprotic solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Improvements introduced in a process for obtaining phenothiazine derivatives, represented by the formula: **(See formula)** and its pharmaceutically acceptable acid addition salts where p has a value of 0 or 1, the improvements of which are to react a compound of formula: **(See formula)** with a compound of formula: where M represents an alkali metal atom and A represents a halogen atom or an alkyl- or aryl-sulfonyloxy group, in an inert solvent, and condensing the quinuclidine derivative formed in the same solvent or after adding a polar aprotic solvent. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7523340A FR2318638A2 (en) | 1975-07-25 | 1975-07-25 | NEW DERIVATIVES OF PHENOTHIAZINE AND PROCESS FOR THEIR PREPARATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES450109A1 true ES450109A1 (en) | 1977-08-01 |
Family
ID=9158390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES450109A Expired ES450109A1 (en) | 1975-07-25 | 1976-07-23 | Phenothiazine derivatives and their preparation |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE844520R (en) |
| ES (1) | ES450109A1 (en) |
| FR (1) | FR2318638A2 (en) |
| GB (1) | GB1492157A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2497806A1 (en) * | 1981-01-13 | 1982-07-16 | Pharmindustrie | NEW PROCESS FOR THE PREPARATION OF N, N-DIMETHYL (AZA-1 BICYCLO (2,2,2) OCTYL-3) -10 10H-PHENOTHIAZINESULFONAMIDE-2 |
| FR2503165A1 (en) * | 1981-04-03 | 1982-10-08 | Pharmindustrie | NOVEL DERIVATIVES OF N, N-DIMETHYL (AZA-1 BICYCLO (2,2,2) OCTYL-3) -10H PHENOTHIAZINESULFONAMIDE-2, PROCESS FOR THEIR PREPARATION AND USE AS MEDICAMENTS |
| FR2509307A1 (en) * | 1981-07-10 | 1983-01-14 | Pharmindustrie | (AZA-1 BICYCLO- (2,2,2) OCTYL-3) 10H PHENOTHIAZINE-SULFONAMIDE-2, ITS DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR USE AS MEDICAMENTS |
| FR2526433B1 (en) * | 1982-05-04 | 1985-10-18 | Pharmuka Lab | DEXTROGYRIC ISOMERS OF AZA-1 BICYCLO (2,2,2) OCTANE DERIVATIVES, THEIR PREPARATION METHOD AND MEDICAMENTS CONTAINING THEM |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1250534A (en) * | 1969-03-03 | 1971-10-20 |
-
1975
- 1975-07-25 FR FR7523340A patent/FR2318638A2/en active Granted
-
1976
- 1976-07-23 ES ES450109A patent/ES450109A1/en not_active Expired
- 1976-07-23 GB GB3089876A patent/GB1492157A/en not_active Expired
- 1976-07-26 BE BE169242A patent/BE844520R/en active
Also Published As
| Publication number | Publication date |
|---|---|
| FR2318638B2 (en) | 1978-12-22 |
| GB1492157A (en) | 1977-11-16 |
| BE844520R (en) | 1976-11-16 |
| FR2318638A2 (en) | 1977-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980202 |