ES451375A1 - Procedimiento para la preparacion de 2-4 diamino-5-bencil-pirimidinas. - Google Patents
Procedimiento para la preparacion de 2-4 diamino-5-bencil-pirimidinas.Info
- Publication number
- ES451375A1 ES451375A1 ES451375A ES451375A ES451375A1 ES 451375 A1 ES451375 A1 ES 451375A1 ES 451375 A ES451375 A ES 451375A ES 451375 A ES451375 A ES 451375A ES 451375 A1 ES451375 A1 ES 451375A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- image
- benzylpyrimidines
- diamino
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XHPZVBGIPQQTQW-UHFFFAOYSA-N 5-benzylpyrimidine-2,4-diamine Chemical class NC1=NC(N)=NC=C1CC1=CC=CC=C1 XHPZVBGIPQQTQW-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- RORTUEWWZUJHTM-UHFFFAOYSA-N 3-aminoprop-2-enenitrile Chemical compound NC=CC#N RORTUEWWZUJHTM-UHFFFAOYSA-N 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para la preparación de 2,4-diamino-5-bencil-pirimidinas de la fórmula general **fórmula** en la que R significa un grupo alcohilo con 1 a 4 átomos de carbono o un átomo de halógeno, caracterizado proque se hace reaccionar en solución alcohólica con guanidina, calentando a reflujo un beta-aminoacrilonitrilo de la fórmula **fórmula** en donde R significa un grupo alcohilo con 1 a 4 átomos de carbono o un átomo de halógeno y R'' representa un grupo anilino, que eventualmente está sustituido , o un grupo morfolino, se separa por destilación el alcohol, y el producto remanente después de separar por destilación el alcohol, el cual producto tiene la fórmula general **fórmula** en la que R tiene los significados antes indicados, se transforma en ácido clorhídrico alcohílico a la temperatura de ebullición, con separación del radial metoximetilo, en el pretendido compuesto de 2,4-diamino-5-bencil-pirimidina y éste se convierte eventualmente en su sal por adición de ácido farmacológicamente compatible.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2546667A DE2546667C3 (de) | 1975-10-17 | 1975-10-17 | 2,4-DiamüH»-5-(3-methoxy-4-hydroxy-5-halogenbenzyl)-pyrimidine, und diese Verbindungen enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES451375A1 true ES451375A1 (es) | 1981-10-16 |
Family
ID=5959437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES451375A Expired ES451375A1 (es) | 1975-10-17 | 1976-09-09 | Procedimiento para la preparacion de 2-4 diamino-5-bencil-pirimidinas. |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5251376A (es) |
| AR (1) | AR210905A1 (es) |
| AT (1) | AT352735B (es) |
| AU (1) | AU1724576A (es) |
| BE (1) | BE846397A (es) |
| CA (1) | CA1055498A (es) |
| CH (1) | CH623313A5 (es) |
| DE (1) | DE2546667C3 (es) |
| ES (1) | ES451375A1 (es) |
| FR (1) | FR2327786A1 (es) |
| GB (1) | GB1522537A (es) |
| GR (1) | GR60352B (es) |
| HU (1) | HU174155B (es) |
| IL (1) | IL50430A0 (es) |
| MX (1) | MX4485E (es) |
| NL (1) | NL7609652A (es) |
| PT (1) | PT65482B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2720771C3 (de) | 1977-05-09 | 1979-11-29 | Ludwig Heumann & Co Gmbh, 8500 Nuernberg | 2,4-Diamino-5-(33-dimethoxy-4thioalkyl-benzyD-pyrimidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| NO791699L (no) * | 1978-05-24 | 1979-11-27 | Wellcome Found | Benzylpyrimidinforbindelser og fremgangsmaate til deres fremstilling |
| HU188588B (en) * | 1982-08-13 | 1986-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for the production of 2,4-diamino-5-benzyl-pyrimidine-derivatives |
-
1975
- 1975-10-17 DE DE2546667A patent/DE2546667C3/de not_active Expired
-
1976
- 1976-07-28 CH CH962676A patent/CH623313A5/de not_active IP Right Cessation
- 1976-08-03 GR GR51404A patent/GR60352B/el unknown
- 1976-08-17 PT PT65482A patent/PT65482B/pt unknown
- 1976-08-27 AU AU17245/76A patent/AU1724576A/en not_active Expired
- 1976-08-31 NL NL7609652A patent/NL7609652A/xx not_active Application Discontinuation
- 1976-09-01 AT AT649276A patent/AT352735B/de not_active IP Right Cessation
- 1976-09-08 IL IL50430A patent/IL50430A0/xx unknown
- 1976-09-09 ES ES451375A patent/ES451375A1/es not_active Expired
- 1976-09-16 FR FR7627872A patent/FR2327786A1/fr active Granted
- 1976-09-21 BE BE170783A patent/BE846397A/xx unknown
- 1976-09-22 AR AR264813A patent/AR210905A1/es active
- 1976-09-27 CA CA262,152A patent/CA1055498A/en not_active Expired
- 1976-10-01 HU HU76HE722A patent/HU174155B/hu unknown
- 1976-10-01 GB GB40800/76A patent/GB1522537A/en not_active Expired
- 1976-10-01 JP JP51118916A patent/JPS5251376A/ja active Pending
- 1976-10-01 MX MX764949U patent/MX4485E/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU174155B (hu) | 1979-11-28 |
| FR2327786A1 (fr) | 1977-05-13 |
| IL50430A0 (en) | 1976-11-30 |
| FR2327786B1 (es) | 1980-04-18 |
| GR60352B (en) | 1978-05-18 |
| DE2546667B2 (de) | 1978-02-09 |
| CA1055498A (en) | 1979-05-29 |
| NL7609652A (nl) | 1977-04-19 |
| ATA649276A (de) | 1979-03-15 |
| PT65482A (de) | 1976-09-01 |
| CH623313A5 (en) | 1981-05-29 |
| AT352735B (de) | 1979-10-10 |
| AU1724576A (en) | 1978-03-02 |
| JPS5251376A (en) | 1977-04-25 |
| AR210905A1 (es) | 1977-09-30 |
| DE2546667A1 (de) | 1977-04-28 |
| BE846397A (fr) | 1977-01-17 |
| GB1522537A (en) | 1978-08-23 |
| DE2546667C3 (de) | 1978-10-12 |
| MX4485E (es) | 1982-05-21 |
| PT65482B (de) | 1978-02-13 |
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