ES452198A1 - Un procedimiento para la preparacion de nuevos derivados de colecalciferol y dihidrotaquisterol. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de colecalciferol y dihidrotaquisterol.

Info

Publication number
ES452198A1
ES452198A1 ES452198A ES452198A ES452198A1 ES 452198 A1 ES452198 A1 ES 452198A1 ES 452198 A ES452198 A ES 452198A ES 452198 A ES452198 A ES 452198A ES 452198 A1 ES452198 A1 ES 452198A1
Authority
ES
Spain
Prior art keywords
preparation
dihidrotaquisterol
colecalciferol
procedure
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES452198A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES452198A1 publication Critical patent/ES452198A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J17/00Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES452198A 1975-10-14 1976-10-07 Un procedimiento para la preparacion de nuevos derivados de colecalciferol y dihidrotaquisterol. Expired ES452198A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62197675A 1975-10-14 1975-10-14

Publications (1)

Publication Number Publication Date
ES452198A1 true ES452198A1 (es) 1977-12-16

Family

ID=24492438

Family Applications (1)

Application Number Title Priority Date Filing Date
ES452198A Expired ES452198A1 (es) 1975-10-14 1976-10-07 Un procedimiento para la preparacion de nuevos derivados de colecalciferol y dihidrotaquisterol.

Country Status (12)

Country Link
US (1) US4069321A (es)
JP (1) JPS5268163A (es)
AU (1) AU1842976A (es)
BE (1) BE847223A (es)
DE (1) DE2646240A1 (es)
DK (1) DK457176A (es)
ES (1) ES452198A1 (es)
FR (1) FR2327790A1 (es)
GB (1) GB1524418A (es)
NL (1) NL7611274A (es)
SE (1) SE7611261L (es)
ZA (1) ZA766097B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53147051A (en) * 1977-05-24 1978-12-21 Teijin Ltd 1alpha-hydroxy-24-dehydro-vitamin d3 and its preparation
US4145346A (en) * 1977-10-03 1979-03-20 Merck & Co., Inc. Preparation of 3β-hydroxy-27-norcholest-5-ene-25-one and intermediates thereof
US4263214A (en) * 1978-07-26 1981-04-21 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4188345A (en) * 1978-07-26 1980-02-12 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4224230A (en) * 1978-07-26 1980-09-23 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4229357A (en) * 1978-07-26 1980-10-21 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same
US4196133A (en) * 1979-03-05 1980-04-01 Wisconsin Alumni Research Foundation 24,24-Difluoro-25-hydroxycholecalciferol
US4201881A (en) * 1979-03-28 1980-05-06 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4230626A (en) * 1979-07-30 1980-10-28 G. D. Searle & Co. 25-Halocholest-5-ene-3β,22-diols and esters thereof
US4230627A (en) * 1979-08-06 1980-10-28 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4287129A (en) * 1980-07-28 1981-09-01 Diamond Shamrock Corp. Synthesis of 1α-hydroxy-7-dehydrosteroids
EP0070588B1 (en) * 1981-07-17 1986-05-07 Duphar International Research B.V Method of preparing 1-alpha-hydroxyvitamin d and 1-alpha-hydroxy-previtamin d compounds, and adduct of a previtamin d or tachysterol compound with a suitable dienophile
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4428946A (en) * 1982-07-26 1984-01-31 Wisconsin Alumni Research Foundation Method of preventing milk fever in dairy cattle
EP0154185B1 (en) * 1984-02-08 1988-10-05 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Calciferol derivatives
IL77668A (en) * 1986-01-21 1989-03-31 Teva Pharma Production of cholecalciferol derivatives and novel intermediates used therefor
US4929609A (en) * 1987-03-12 1990-05-29 Hoffmann-La Roche Inc. 25, 28-dihydroxyergocalciferol and 1,25,28-trihydroxyergocalciferol compositions thereof and their use in the treatment of hyperproliferative disease
JP2525478B2 (ja) * 1989-03-01 1996-08-21 帝人株式会社 安定性の改良された活性型ビタミンd▲下3▼類固型製剤
US5401731A (en) * 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
KR100257445B1 (ko) * 1992-04-15 2000-08-01 에드워드 이. 데이비스 스테롤 혼합물로부터 5,7-디엔작용기를 함유한 스테로이드를 분리하는 방법
JP2905091B2 (ja) * 1994-06-24 1999-06-14 日本バルカー工業株式会社 フッ素樹脂被覆ガスケットの製造方法
KR100756823B1 (ko) * 2001-10-23 2007-09-07 주식회사 엘지생활건강 신규한 폴리에톡실화 콜레칼시페롤 유도체 및 그의 제조방법
US7795427B2 (en) * 2006-02-14 2010-09-14 New York University Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass
EP3965773B1 (en) * 2019-05-09 2025-12-31 Fermenta Biotech Limited NEW PROCESS FOR THE SYNTHESIS OF 25-OH CHOLESTEROL/CALCIFEDIOL FROM PHYTOSTEROL

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2862934A (en) * 1955-06-14 1958-12-02 Philips Corp Method of producing tachysterol and dihydrotachysterol
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US3607888A (en) * 1969-08-07 1971-09-21 Wisconsin Alumni Res Found 25-hydroxytachysterol3 25-hydroxydihydrotachysterol3 and methods for preparing same

Also Published As

Publication number Publication date
GB1524418A (en) 1978-09-13
DE2646240A1 (de) 1977-04-28
NL7611274A (nl) 1977-04-18
JPS5268163A (en) 1977-06-06
AU1842976A (en) 1978-04-13
SE7611261L (sv) 1977-04-15
FR2327790B1 (es) 1979-07-20
DK457176A (da) 1977-04-15
ZA766097B (en) 1978-05-30
BE847223A (fr) 1977-04-13
FR2327790A1 (fr) 1977-05-13
US4069321A (en) 1978-01-17

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