ES453501A1 - Derivatives of thienamycin and its isomers - Google Patents
Derivatives of thienamycin and its isomersInfo
- Publication number
- ES453501A1 ES453501A1 ES453501A ES453501A ES453501A1 ES 453501 A1 ES453501 A1 ES 453501A1 ES 453501 A ES453501 A ES 453501A ES 453501 A ES453501 A ES 453501A ES 453501 A1 ES453501 A1 ES 453501A1
- Authority
- ES
- Spain
- Prior art keywords
- thienamycin
- hydrogen
- formula
- carbon atoms
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un procedimiento para la preparación de nuevos derivados N-metilénicos de tienamicina de fórmula: **(Fórmula)** y las sales, ésteres, éteres y amidas derivados del mismo farmacéuticamente aceptables, donde Y es -NR1R2 y X es hidrógeno o R al mismo tiempo R1 y R2 están seleccionados independientemente entre R, hidrógeno, nitro, hidroxilo, alcoxi de 1 a 6 átomos de carbono, amino, mono-, di- y tri-alquilamino donde los radicales alquilo contiene cada uno de ellos de 1 a 6 átomos de carbono; R1 y R2 pueden estar unidos para formar un heteroarilo o un heterociclo, monocíclicos o bicíclicos, sustituidos o no sustituidos, que contiene (junto con el átomo de nitrógeno al que están unidos) de 4 a 10 átomos de los que uno o más pueden ser un heteroátomo adicional seleccionado entre oxígeno, azufre o nitrógeno.A process for the preparation of new N-methylene derivatives of thienamycin of the formula: **(Formula)** and the pharmaceutically acceptable salts, esters, ethers and amides thereof, where Y is -NR1R2 and X is hydrogen or R al same time R1 and R2 are independently selected from R, hydrogen, nitro, hydroxyl, alkoxy of 1 to 6 carbon atoms, amino, mono-, di- and tri-alkylamino where the alkyl radicals each contain from 1 to 6 carbon atoms; R1 and R2 may be joined to form a substituted or unsubstituted monocyclic or bicyclic heteroaryl or heterocycle containing (together with the nitrogen atom to which they are attached) from 4 to 10 atoms of which one or more may be an additional heteroatom selected from oxygen, sulfur or nitrogen.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63429675A | 1975-11-21 | 1975-11-21 | |
| US67626176A | 1976-04-12 | 1976-04-12 | |
| US73365476A | 1976-10-18 | 1976-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES453501A1 true ES453501A1 (en) | 1978-03-01 |
Family
ID=27417545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES453501A Expired ES453501A1 (en) | 1975-11-21 | 1976-11-19 | Derivatives of thienamycin and its isomers |
Country Status (27)
| Country | Link |
|---|---|
| AT (1) | AT358168B (en) |
| AU (1) | AU512383B2 (en) |
| BG (1) | BG34037A3 (en) |
| CA (1) | CA1083577A (en) |
| CH (2) | CH632510A5 (en) |
| DD (1) | DD127742A5 (en) |
| DE (1) | DE2652679A1 (en) |
| DK (1) | DK157401C (en) |
| EG (1) | EG12261A (en) |
| ES (1) | ES453501A1 (en) |
| FI (1) | FI62306C (en) |
| FR (1) | FR2332012A1 (en) |
| GB (1) | GB1570990A (en) |
| GR (1) | GR62072B (en) |
| HK (1) | HK29683A (en) |
| HU (1) | HU180865B (en) |
| IE (1) | IE44433B1 (en) |
| IL (1) | IL50911A (en) |
| KE (1) | KE3286A (en) |
| NL (1) | NL189297C (en) |
| NO (1) | NO153298C (en) |
| NZ (1) | NZ182630A (en) |
| PH (1) | PH16714A (en) |
| PL (1) | PL110937B1 (en) |
| PT (1) | PT65865B (en) |
| SE (1) | SE427841B (en) |
| SG (1) | SG10983G (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1593524A (en) * | 1976-11-19 | 1981-07-15 | Merck & Co Inc | 1-carba-2-penem-3-carboxylic acids |
| SE436569B (en) * | 1977-05-05 | 1985-01-07 | Merck & Co Inc | ANALOGY PROCEDURE FOR THE PREPARATION OF TIENAMYCIN DERIVATIVES |
| US4232030A (en) * | 1977-09-15 | 1980-11-04 | Merck & Co., Inc. | Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone |
| DK153486C (en) * | 1978-07-03 | 1988-11-28 | Merck & Co Inc | ANALOGY PROCEDURE FOR THE PREPARATION OF CRYSTALLINIC N-FORMIMIDOYL-THIENAMYCINE MONOHYDRATE |
| EP0044170A1 (en) * | 1980-07-11 | 1982-01-20 | Beecham Group Plc | Beta-lactam antibiotics, their preparation and use |
| WO1992004054A1 (en) * | 1990-08-30 | 1992-03-19 | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY, PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon | Substituted amidines having high binding to the sigma receptor and the use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1004670A (en) * | 1963-04-23 | 1965-09-15 | Beecham Res Lab | Penicillins |
| GB1348984A (en) * | 1970-06-16 | 1974-03-27 | Merck & Co Inc | Antibiotics and processes for their production |
| US3950357A (en) * | 1974-11-25 | 1976-04-13 | Merck & Co., Inc. | Antibiotics |
-
1976
- 1976-11-15 NZ NZ182630A patent/NZ182630A/en unknown
- 1976-11-15 AU AU19647/76A patent/AU512383B2/en not_active Expired
- 1976-11-15 IL IL50911A patent/IL50911A/en unknown
- 1976-11-18 FI FI763308A patent/FI62306C/en not_active IP Right Cessation
- 1976-11-18 PH PH19142A patent/PH16714A/en unknown
- 1976-11-18 IE IE2542/76A patent/IE44433B1/en not_active IP Right Cessation
- 1976-11-19 DE DE19762652679 patent/DE2652679A1/en active Granted
- 1976-11-19 FR FR7634882A patent/FR2332012A1/en active Granted
- 1976-11-19 CA CA266,186A patent/CA1083577A/en not_active Expired
- 1976-11-19 DD DD7600195868A patent/DD127742A5/en unknown
- 1976-11-19 NO NO763958A patent/NO153298C/en unknown
- 1976-11-19 GB GB48240/76A patent/GB1570990A/en not_active Expired
- 1976-11-19 AT AT863476A patent/AT358168B/en active Protection Beyond IP Right Term
- 1976-11-19 DK DK523576A patent/DK157401C/en not_active IP Right Cessation
- 1976-11-19 SE SE7612963A patent/SE427841B/en not_active IP Right Cessation
- 1976-11-19 ES ES453501A patent/ES453501A1/en not_active Expired
- 1976-11-19 PT PT65865A patent/PT65865B/en unknown
- 1976-11-19 NL NLAANVRAGE7612939,A patent/NL189297C/en not_active IP Right Cessation
- 1976-11-19 BG BG034723A patent/BG34037A3/en unknown
- 1976-11-19 CH CH1462376A patent/CH632510A5/en not_active IP Right Cessation
- 1976-11-19 HU HU76ME2032A patent/HU180865B/en unknown
- 1976-11-20 PL PL1976193809A patent/PL110937B1/en not_active IP Right Cessation
- 1976-11-20 GR GR52223A patent/GR62072B/en unknown
- 1976-11-21 EG EG76723A patent/EG12261A/en active
-
1980
- 1980-09-26 CH CH725580A patent/CH633800A5/en not_active IP Right Cessation
-
1983
- 1983-03-14 SG SG109/83A patent/SG10983G/en unknown
- 1983-04-08 KE KE3286A patent/KE3286A/en unknown
- 1983-08-18 HK HK296/83A patent/HK29683A/en unknown
Also Published As
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