ES453722A1 - Cephalospoline compound and process for preparing same - Google Patents
Cephalospoline compound and process for preparing sameInfo
- Publication number
- ES453722A1 ES453722A1 ES453722A ES453722A ES453722A1 ES 453722 A1 ES453722 A1 ES 453722A1 ES 453722 A ES453722 A ES 453722A ES 453722 A ES453722 A ES 453722A ES 453722 A1 ES453722 A1 ES 453722A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- new
- cephalospoline
- compound
- preparing same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 229960003324 clavulanic acid Drugs 0.000 abstract 1
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Cephalosporins of formula (I) and their pharmaceutically acceptable salts and esters are new (R = organic acylamino, Y = N-contg. 5-membered ring. n = 0 or 1. R1 and R2 are H or 1-6C alkyl. R3 and R4 are each 1-3C alkyl or together they complete a monocyclic ring). Also new are the intermediates of formulae (VI) and (IXA) (where Rx = H or a blocking gp. m = 0 or 1. The dotted line is a double bond at 2 or 3 posn.). Cpds. (I) are antibacterials for use in human or veterinary medicine and are administered in usual oral, topical or parenteral forms e.g. unit doses of 50-500 mg for an adult human dose of 0.1-3 g/day. They are pref. used together with clavulanic acid or its derivs. A typical cpd. is 7- D-alpha-(3-benzoyl-3-methylureido) phenylacetamido -3-(2-carbamoylmethyl-1,3,4-oxadiazol-5-ylthio) methylceph-3-em-4-carboxylic acid/.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB48719/75A GB1570582A (en) | 1975-11-27 | 1975-11-27 | Cephalosporins |
| GB1495276 | 1976-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES453722A1 true ES453722A1 (en) | 1979-06-01 |
Family
ID=26250914
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES453722A Expired ES453722A1 (en) | 1975-11-27 | 1976-11-26 | Cephalospoline compound and process for preparing same |
| ES475659A Expired ES475659A1 (en) | 1975-11-27 | 1978-12-01 | Cephalospoline compound and process for preparing same |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES475659A Expired ES475659A1 (en) | 1975-11-27 | 1978-12-01 | Cephalospoline compound and process for preparing same |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5278894A (en) |
| AU (1) | AU2008776A (en) |
| DE (1) | DE2653621A1 (en) |
| DK (1) | DK536176A (en) |
| ES (2) | ES453722A1 (en) |
| FI (1) | FI763363A7 (en) |
| FR (1) | FR2332757A1 (en) |
| GR (1) | GR61821B (en) |
| IL (1) | IL50945A0 (en) |
| NL (1) | NL7613243A (en) |
| NO (1) | NO764034L (en) |
| NZ (1) | NZ182649A (en) |
| PH (1) | PH13321A (en) |
| SE (1) | SE7613150L (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4278670A (en) * | 1976-07-12 | 1981-07-14 | Smithkline Corporation | 7-Alpha-oxyiminoacylcephalosporins |
| AU510280B2 (en) * | 1976-08-30 | 1980-06-19 | Bristol-Myers Company | Antibacterial cephalosporin agents |
| JPS53155051U (en) * | 1977-05-10 | 1978-12-06 | ||
| JPS54106495A (en) * | 1978-02-09 | 1979-08-21 | Dai Ichi Seiyaku Co Ltd | Cephem derivative |
| DK225179A (en) | 1978-06-22 | 1979-12-23 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR PREPARING CEPHALOSPORINE DERIVATIVES |
-
1976
- 1976-11-17 NZ NZ182649A patent/NZ182649A/en unknown
- 1976-11-19 IL IL50945A patent/IL50945A0/en unknown
- 1976-11-23 FI FI763363A patent/FI763363A7/fi not_active Application Discontinuation
- 1976-11-24 FR FR7635341A patent/FR2332757A1/en not_active Withdrawn
- 1976-11-24 SE SE7613150A patent/SE7613150L/en unknown
- 1976-11-25 DE DE19762653621 patent/DE2653621A1/en active Pending
- 1976-11-25 NO NO764034A patent/NO764034L/no unknown
- 1976-11-25 GR GR52263A patent/GR61821B/en unknown
- 1976-11-26 ES ES453722A patent/ES453722A1/en not_active Expired
- 1976-11-26 NL NL7613243A patent/NL7613243A/en not_active Application Discontinuation
- 1976-11-26 DK DK536176A patent/DK536176A/en not_active Application Discontinuation
- 1976-11-27 JP JP51142811A patent/JPS5278894A/en active Pending
- 1976-11-29 AU AU20087/76A patent/AU2008776A/en not_active Expired
-
1977
- 1977-11-24 PH PH20477A patent/PH13321A/en unknown
-
1978
- 1978-12-01 ES ES475659A patent/ES475659A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES475659A1 (en) | 1979-10-16 |
| FR2332757A1 (en) | 1977-06-24 |
| NZ182649A (en) | 1979-11-01 |
| JPS5278894A (en) | 1977-07-02 |
| FI763363A7 (en) | 1977-05-28 |
| SE7613150L (en) | 1977-05-28 |
| GR61821B (en) | 1979-01-22 |
| NO764034L (en) | 1977-05-31 |
| DK536176A (en) | 1977-05-28 |
| IL50945A0 (en) | 1977-01-31 |
| NL7613243A (en) | 1977-06-01 |
| PH13321A (en) | 1980-03-13 |
| DE2653621A1 (en) | 1977-06-08 |
| AU2008776A (en) | 1978-06-08 |
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