ES455365A1 - Peptide and derivatives - Google Patents

Peptide and derivatives

Info

Publication number
ES455365A1
ES455365A1 ES455365A ES455365A ES455365A1 ES 455365 A1 ES455365 A1 ES 455365A1 ES 455365 A ES455365 A ES 455365A ES 455365 A ES455365 A ES 455365A ES 455365 A1 ES455365 A1 ES 455365A1
Authority
ES
Spain
Prior art keywords
peptide
radical
formula
derivatives
dialkylamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES455365A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB2900/76A external-priority patent/GB1577114A/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES455365A1 publication Critical patent/ES455365A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un método de preparación de un péptido dotado de actividad biológica análoga a la de la morfina, de fórmula (I): **(Fórmula)** o una sal, éster, amida, N-alcohilamida o N,N-dialcohilamida del misma, o una de sus sales de adición de ácido, en donde X1 y X2 son iguales o diferentes y cada uno es el radical de un aminoácido básico (D ó L); X3 es un radical D ó L.A method of preparing a peptide endowed with biological activity analogous to that of morphine, of formula (I): **(Formula)** or a salt, ester, amide, N-alkylamide or N,N-dialkylamide thereof , or one of their acid addition salts, wherein X1 and X2 are the same or different and each is the radical of a basic amino acid (D or L); X3 is a D or L radical.

ES455365A 1976-01-26 1977-01-26 Peptide and derivatives Expired ES455365A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2900/76A GB1577114A (en) 1976-01-26 1976-01-26 Biologically active peptides
GB848176 1976-03-03
GB4882176 1976-11-23

Publications (1)

Publication Number Publication Date
ES455365A1 true ES455365A1 (en) 1978-05-16

Family

ID=27254145

Family Applications (1)

Application Number Title Priority Date Filing Date
ES455365A Expired ES455365A1 (en) 1976-01-26 1977-01-26 Peptide and derivatives

Country Status (11)

Country Link
JP (1) JPS5291839A (en)
CH (1) CH644352A5 (en)
DE (1) DE2703109A1 (en)
DK (1) DK33177A (en)
ES (1) ES455365A1 (en)
FI (1) FI70228C (en)
FR (1) FR2338925A1 (en)
HU (1) HU184704B (en)
IL (1) IL51332A (en)
NL (1) NL7700785A (en)
SE (1) SE7708404L (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003000A (en) * 1975-05-27 1977-01-11 Sperry Rand Corporation Sinusoidal oscillator with electronically variable frequency
US4261888A (en) * 1976-04-12 1981-04-14 Sandoz Ltd. Organic compounds
FR2359817A1 (en) * 1976-07-27 1978-02-24 Reckitt & Colmann Prod Ltd Peptide cpds. contg. tyrosine, glycine, phenylalanine and d-amino acid - local anaesthetics, smooth muscle relaxants, adrenergic neutron blockers, beta-stimulants etc.
AU2768977A (en) * 1976-08-09 1979-02-15 Searle & Co 1-substituted enkephalin derivatives
HU178001B (en) * 1976-09-16 1982-02-28 Gyogyszekutato Intezet Process for preparing new pentapeptides with morphine-like activity and derivatives thereof
DE2819277A1 (en) * 1977-05-16 1978-11-23 Sandoz Ag NEW POLYPEPTIDE DERIVATIVES, THEIR PRODUCTION AND USE
GB2000784B (en) * 1977-07-05 1982-01-20 American Home Prod Analgesic polypetide
EP0000559B1 (en) * 1977-07-22 1983-10-05 The Wellcome Foundation Limited Pentapeptide-n-alkylamides and their acid addition salts, methods for preparation of these compounds and pharmaceutical formulations containing them
US4264491A (en) * 1977-10-03 1981-04-28 Eli Lilly And Company Analgesic compounds
HU182051B (en) * 1978-05-02 1983-12-28 Takeda Chemical Industries Ltd Process for preparing tetrapeptide-hydrazyde derivatives
US4278596A (en) * 1978-08-08 1981-07-14 American Home Products Corporation Analgesic pentapeptides
CA1175810A (en) * 1979-03-30 1984-10-09 Frank A. Momany Synthetic peptides having pituitary growth hormone releasing activity
US4247543A (en) * 1979-04-09 1981-01-27 Sandoz Ltd. Organic compounds
US4396606A (en) * 1979-11-05 1983-08-02 Addiction Research Foundation Novel polypeptide analgesics
EP0044451B1 (en) * 1980-07-17 1984-04-18 Sandoz Ag Novel pentapeptides, processes for their production, pharmaceutical compositions comprising said pentapeptides and their use
FR2488253A1 (en) * 1980-08-08 1982-02-12 Roques Bernard NEW PEPTIDES AND THEIR THERAPEUTIC APPLICATION
WO1983002272A1 (en) * 1981-12-28 1983-07-07 Beckman Instruments Inc Synthetic peptides having pituitary growth hormone releasing activity
US4491541A (en) * 1982-11-10 1985-01-01 Farmitalia Carlo Erba Peptides
JPH0680079B2 (en) * 1984-11-09 1994-10-12 エーザイ株式会社 Polypeptide
AU618029B2 (en) * 1987-11-02 1991-12-12 Imperial Chemical Industries Plc Polypeptide compounds
EP0644772B1 (en) * 1992-11-12 2003-04-02 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Opioid peptides
AU2010236730B2 (en) * 2009-04-13 2012-09-20 Elc Management Llc Methionine sulfoxide peptide, compositions and methods of use
US10278957B2 (en) 2017-09-11 2019-05-07 Protagonist Therapeutics, Inc. Opioid agonist peptides and uses thereof

Also Published As

Publication number Publication date
FR2338925A1 (en) 1977-08-19
DK33177A (en) 1977-07-27
HU184704B (en) 1984-10-29
SE7708404L (en) 1977-07-27
IL51332A0 (en) 1977-03-31
DE2703109A1 (en) 1977-08-04
CH644352A5 (en) 1984-07-31
FI770254A7 (en) 1977-07-27
IL51332A (en) 1980-09-16
FI70228C (en) 1986-09-15
FR2338925B1 (en) 1980-08-08
FI70228B (en) 1986-02-28
JPS5291839A (en) 1977-08-02
NL7700785A (en) 1977-07-28

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