ES456252A1 - Anti-microbial bis-pyridinium compounds - Google Patents

Anti-microbial bis-pyridinium compounds

Info

Publication number
ES456252A1
ES456252A1 ES456252A ES456252A ES456252A1 ES 456252 A1 ES456252 A1 ES 456252A1 ES 456252 A ES456252 A ES 456252A ES 456252 A ES456252 A ES 456252A ES 456252 A1 ES456252 A1 ES 456252A1
Authority
ES
Spain
Prior art keywords
bis
amino
pyridinium
microbial
alkanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES456252A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/734,729 external-priority patent/US4107313A/en
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES456252A1 publication Critical patent/ES456252A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención se relaciona con bis-(4-amino-l-piridinio) alcanos y alfa, alfa''-bis- (4-amino-l-piridinio) xilenos y la preparación de los mismos. Estos compuestos son útiles para controlar bacterias, hongos y virus de herpes, y en ciertos casos para impedir la formación de placas dentales. Un grupo de bis-(4-amiono-l-piridinio)n aleanos como intermediarios en la preparación de los bis-(4-amino-l-piperidino) alcanos correspondientes que se dice que tienen efectos bactericatáticos y bactericidas.The present invention relates to bis-(4-amino-l-pyridinium)alkanes and alpha,alpha''-bis-(4-amino-l-pyridinium)xylenes and the preparation thereof. These compounds are useful in controlling bacteria, fungi, and herpes viruses, and in certain cases in preventing the formation of dental plaque. A group of bis-(4-amino-l-pyridinium)n alkanes as intermediates in the preparation of the corresponding bis-(4-amino-l-piperidino) alkanes that are said to have bactericatatic and bactericidal effects.

ES456252A 1976-02-25 1977-02-24 Anti-microbial bis-pyridinium compounds Expired ES456252A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66110176A 1976-02-25 1976-02-25
US66112876A 1976-02-25 1976-02-25
US72131576A 1976-09-07 1976-09-07
US05/734,729 US4107313A (en) 1976-02-25 1976-10-22 α,α-Bis-[4-(R-amino)-1-pyridinium]xylenes and antibacterial and antifungal uses

Publications (1)

Publication Number Publication Date
ES456252A1 true ES456252A1 (en) 1978-02-01

Family

ID=27505307

Family Applications (1)

Application Number Title Priority Date Filing Date
ES456252A Expired ES456252A1 (en) 1976-02-25 1977-02-24 Anti-microbial bis-pyridinium compounds

Country Status (23)

Country Link
JP (1) JPS6033108B2 (en)
AR (2) AR214876A1 (en)
AT (1) AT355571B (en)
AU (1) AU510149B2 (en)
BE (1) BE851807A (en)
CA (1) CA1073911A (en)
CH (1) CH620907A5 (en)
DE (1) DE2708331A1 (en)
DK (1) DK147638C (en)
ES (1) ES456252A1 (en)
FI (1) FI66850C (en)
FR (1) FR2342286A1 (en)
GB (1) GB1533952A (en)
HK (1) HK67484A (en)
IE (1) IE45336B1 (en)
IL (1) IL51520A (en)
LU (1) LU76837A1 (en)
MX (1) MX5132E (en)
NL (1) NL186086C (en)
NO (2) NO148779C (en)
PH (2) PH22315A (en)
PT (1) PT66224B (en)
SE (1) SE432421B (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4420484A (en) 1979-08-13 1983-12-13 Sterling Drug Inc. Basic amino or ammonium antimicrobial agent-polyethylene glycol ester surfactant-betaine and/or amine oxide surfactant compositions and method of use therof
USRE32300E (en) * 1979-08-13 1986-12-02 Sterling Drug Inc. Basic amino or ammonium antimicrobial agent-polyethylene glycol ester surfactant-betaine and/or amine oxide surfactant compositions and method of use thereof
DE19647402A1 (en) * 1996-11-15 1998-05-20 Hoechst Schering Agrevo Gmbh Substituted nitrogen heterocycles, processes for their preparation and their use as pesticides
DE19647413A1 (en) * 1996-11-15 1998-05-20 Hoechst Schering Agrevo Gmbh Substituted nitrogen heterocycles, processes for their preparation and their use as pesticides
DE19647317A1 (en) * 1996-11-15 1998-05-20 Hoechst Schering Agrevo Gmbh Substituted nitrogen heterocycles, processes for their preparation and their use as pesticides
DE10005853C1 (en) * 2000-02-10 2002-02-07 Schuelke & Mayr Gmbh Process for the preparation of bis- (4-amino-1-pyridinium) alkanes
DE10205883A1 (en) * 2002-02-13 2003-08-21 Schuelke & Mayr Gmbh Aqueous antiseptic based on bispyridiniumalkanes
TWI278315B (en) * 2003-06-13 2007-04-11 Ind Tech Res Inst A compound having anti-virus activity
ES2237332B1 (en) * 2004-01-14 2006-11-01 Consejo Sup. Investig. Cientificas DERIVATIVES OF PIRIDINIO AND QUINOLINIO.
DE102005002643B4 (en) * 2005-01-19 2007-11-22 Schülke & Mayr GmbH Compositions for hygienic hand disinfection and disinfecting hand washing
DE102005002645A1 (en) 2005-01-19 2006-07-20 Schülke & Mayr GmbH Alcoholic compositions for disinfection
DE102005002644A1 (en) * 2005-01-19 2006-07-20 Schülke & Mayr GmbH Compositions for hygienic hand disinfection and disinfecting hand washing
DE102005063375A1 (en) 2005-09-15 2007-04-19 Schülke & Mayr GmbH Antimicrobial preparations containing octenidine dihydrochloride encapsulated in liposomes
DE102005045145B4 (en) 2005-09-15 2025-09-25 Schülke & Mayr GmbH Use of octenidine dihydrochloride in semi-solid preparations
DE102005048132A1 (en) * 2005-10-06 2007-04-12 Bayer Innovation Gmbh Process for producing antimicrobial plastic compositions
DE102005048131A1 (en) * 2005-10-06 2007-04-12 Bayer Innovation Gmbh Antimicrobial plastic composition with low elution rate and long efficacy
DE102006012991A1 (en) 2006-03-22 2007-10-11 Bayer Innovation Gmbh Method and device for optically reading information
DE102006051891A1 (en) * 2006-10-31 2008-05-08 Schülke & Mayr GmbH Antimicrobial composition containing Bispyridiniumalkan
RU2345068C2 (en) * 2006-12-12 2009-01-27 Некоммерческая организация Учреждение Институт проблем химической физики Российской академии наук (статус государственного учреждения) (ИПХФ РАН) Method of obtaining 4-(alkylamino)pyridine
DE102008011691A1 (en) 2008-02-28 2009-09-10 Schülke & Mayr GmbH Stabilized antimicrobial composition containing bispyridiniumalkane
DE102009049504A1 (en) 2009-10-15 2011-04-21 Schülke & Mayr GmbH Wound and mucous membrane antiseptic based on bispyridiniumalkanes
DE102010022367A1 (en) 2010-04-20 2011-10-20 Klosterfrau Berlin Gmbh Pharmaceutical composition in form of lubricating agent or gel used for treating and preventing infections and pain associated with catheterization comprises octenidine or its salts and local anesthetic
EP2384733B1 (en) * 2010-05-07 2016-07-27 Ivoclar Vivadent AG Antimicrobial dental materials
DE102010025932A1 (en) 2010-07-02 2012-01-05 Schülke & Mayr GmbH Antiseptic based on bispyridiniumalkanes
DE102011077432A1 (en) * 2011-06-10 2012-12-13 Schülke & Mayr GmbH Use of bispyridiniumalkanes to kill spores
DE102012215511A1 (en) 2012-08-31 2014-06-12 Schülke & Mayr GmbH Process for the preparation of a semi-solid preparation containing bispyridiniumalkane
DE102013223657A1 (en) 2013-11-20 2015-05-21 Schülke & Mayr GmbH Kit for the production of Bispyridiniumalkan containing foams
DE102014107413A1 (en) 2014-05-26 2015-11-26 Schülke & Mayr GmbH Kit for coloring of disinfected areas of a surface
DE102014107412A1 (en) 2014-05-26 2015-12-17 Schülke & Mayr GmbH Colored disinfecting preparation based on bispyridiniumalkane
DE102014115080A1 (en) 2014-10-16 2016-04-21 Schülke & Mayr GmbH Use of fatty acid esters to improve the antimicrobial effectiveness of an alcoholic disinfectant
CN111051285A (en) * 2017-08-21 2020-04-21 迪氏曼卡博金艾美斯有限公司 Octenidine-based compounds
EP3771338A1 (en) 2019-07-29 2021-02-03 The Procter & Gamble Company Acidic antimicrobial composition
EP3771339A1 (en) * 2019-07-29 2021-02-03 The Procter & Gamble Company Disinfectant composition
EP3771770B1 (en) 2019-07-29 2025-04-09 The Procter & Gamble Company Antimicrobial freshening compositions
EP3771337B1 (en) 2019-07-29 2026-04-29 The Procter & Gamble Company Antimicrobial composition
EP3771741A1 (en) 2019-07-29 2021-02-03 The Procter & Gamble Company Fabric treatment
EP3816272B1 (en) 2019-10-31 2023-11-01 The Procter & Gamble Company Fabric care composition
CN114989076A (en) * 2022-06-07 2022-09-02 八叶草健康产业研究院(厦门)有限公司 A kind of preparation method of octenidine base
JP2025009797A (en) 2023-06-30 2025-01-20 花王株式会社 Biofilm disinfectant composition
WO2025004479A1 (en) 2023-06-30 2025-01-02 花王株式会社 Biofilm remover composition
CZ310490B6 (en) * 2024-02-20 2025-08-06 Fakultní nemocnice Hradec Králové Quaternary ammonium salt with a broad antimicrobial spectrum, method of its preparation, disinfectant compositions and their use

Also Published As

Publication number Publication date
IE45336L (en) 1977-08-25
AT355571B (en) 1980-03-10
DE2708331A1 (en) 1977-09-08
JPS6033108B2 (en) 1985-08-01
PH22315A (en) 1988-07-29
DE2708331C2 (en) 1991-03-21
AR218052A1 (en) 1980-05-15
NO150758C (en) 1984-12-12
NL7701965A (en) 1977-08-29
PH25097A (en) 1991-02-19
DK147638B (en) 1984-10-29
AR214876A1 (en) 1979-08-15
FR2342286A1 (en) 1977-09-23
NO148779C (en) 1983-12-14
AU510149B2 (en) 1980-06-12
BE851807A (en) 1977-08-25
DK81277A (en) 1977-08-26
FI770593A7 (en) 1977-08-26
CA1073911A (en) 1980-03-18
LU76837A1 (en) 1977-09-12
FI66850B (en) 1984-08-31
IL51520A0 (en) 1977-04-29
IE45336B1 (en) 1982-08-11
PT66224B (en) 1978-07-14
MX5132E (en) 1983-03-28
SE432421B (en) 1984-04-02
FI66850C (en) 1984-12-10
PT66224A (en) 1977-03-01
JPS52105228A (en) 1977-09-03
IL51520A (en) 1980-12-31
FR2342286B1 (en) 1979-03-09
GB1533952A (en) 1978-11-29
NO150758B (en) 1984-09-03
DK147638C (en) 1985-07-15
NO770631L (en) 1977-08-26
NL186086B (en) 1990-04-17
AU2258277A (en) 1978-08-31
NO148779B (en) 1983-09-05
NO823274L (en) 1977-08-26
HK67484A (en) 1984-09-07
SE7702072L (en) 1977-10-10
ATA129777A (en) 1979-08-15
CH620907A5 (en) 1980-12-31
NL186086C (en) 1990-09-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103