ES456902A1 - (2-pyrimidinyl-thio)-alkanoic acid amides and their preparation - Google Patents
(2-pyrimidinyl-thio)-alkanoic acid amides and their preparationInfo
- Publication number
- ES456902A1 ES456902A1 ES456902A ES456902A ES456902A1 ES 456902 A1 ES456902 A1 ES 456902A1 ES 456902 A ES456902 A ES 456902A ES 456902 A ES456902 A ES 456902A ES 456902 A1 ES456902 A1 ES 456902A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pyrimidinyl
- thio
- acid amides
- alkanoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 2-pyrimidinyl-thio Chemical group 0.000 title abstract 4
- 150000001408 amides Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 abstract 4
- 150000007513 acids Chemical class 0.000 abstract 4
- 150000003335 secondary amines Chemical class 0.000 abstract 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001263 acyl chlorides Chemical class 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000002402 anti-lipaemic effect Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Novel amides of (2-pyrimidylthio)-alkanoic acids possessing an antilipemic activity and methods for their preparation by reaction of an activated derivative of the corresponding acids, such as an acyl chloride or mixed anhydride, and a secondary amine, or by reaction of the corresponding (2-pyrimidinylthio)-alkanoic acids and aziridine or finally by fusion of the amides of (4,6-dichloro-2-pyrimidinylthio)-alkanoic acids with a secondary amine are described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21317/76A IT1063074B (en) | 1976-03-17 | 1976-03-17 | ACID AMIDES (Z-PYRIMIDINYLTI) AL CANOICS AS ANTI-LIPEMIC AGENTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES456902A1 true ES456902A1 (en) | 1978-01-16 |
Family
ID=11180012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES456902A Expired ES456902A1 (en) | 1976-03-17 | 1977-03-16 | (2-pyrimidinyl-thio)-alkanoic acid amides and their preparation |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS52113983A (en) |
| BE (1) | BE852401A (en) |
| CA (1) | CA1081230A (en) |
| CH (1) | CH631169A5 (en) |
| DE (1) | DE2711149C3 (en) |
| DK (1) | DK143558C (en) |
| ES (1) | ES456902A1 (en) |
| FR (1) | FR2344545A1 (en) |
| GB (1) | GB1532195A (en) |
| IT (1) | IT1063074B (en) |
| MX (1) | MX4818E (en) |
| NL (1) | NL166933C (en) |
| PH (1) | PH14865A (en) |
| SE (1) | SE434743B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1211096B (en) * | 1981-08-20 | 1989-09-29 | Lpb Ist Farm | PYRIMIDINES AND S.TRIAZINICS HYPOLIPIDEMIZING ADAPTITY. |
| JPS59199673A (en) * | 1983-04-25 | 1984-11-12 | Sumitomo Chem Co Ltd | Nitrogen-containing heterocyclic compound, its preparation and pesticide containing the same |
| FR2636064B1 (en) * | 1988-09-08 | 1990-12-07 | Fabre Sa Pierre | THIOFORMAMIDINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
| WO2002100836A2 (en) * | 2001-06-12 | 2002-12-19 | Active Pass Pharmaceuticals, Inc. | Compounds, compositions and methods for modulating beta-amyloid production |
-
1976
- 1976-03-17 IT IT21317/76A patent/IT1063074B/en active
-
1977
- 1977-02-23 PH PH19485A patent/PH14865A/en unknown
- 1977-03-08 CA CA273,420A patent/CA1081230A/en not_active Expired
- 1977-03-14 CH CH317377A patent/CH631169A5/en not_active IP Right Cessation
- 1977-03-14 BE BE2055735A patent/BE852401A/en not_active IP Right Cessation
- 1977-03-15 FR FR7707617A patent/FR2344545A1/en active Granted
- 1977-03-15 DE DE2711149A patent/DE2711149C3/en not_active Expired
- 1977-03-15 GB GB10995/77A patent/GB1532195A/en not_active Expired
- 1977-03-15 SE SE7702922A patent/SE434743B/en unknown
- 1977-03-16 JP JP2811277A patent/JPS52113983A/en active Granted
- 1977-03-16 DK DK114377A patent/DK143558C/en not_active IP Right Cessation
- 1977-03-16 NL NL7702821.A patent/NL166933C/en not_active IP Right Cessation
- 1977-03-16 MX MX775544U patent/MX4818E/en unknown
- 1977-03-16 ES ES456902A patent/ES456902A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK143558B (en) | 1981-09-07 |
| GB1532195A (en) | 1978-11-15 |
| MX4818E (en) | 1982-10-20 |
| PH14865A (en) | 1982-01-08 |
| SE434743B (en) | 1984-08-13 |
| FR2344545A1 (en) | 1977-10-14 |
| NL7702821A (en) | 1977-09-20 |
| DE2711149B2 (en) | 1980-04-24 |
| BE852401A (en) | 1977-07-01 |
| NL166933B (en) | 1981-05-15 |
| DK114377A (en) | 1977-09-18 |
| SE7702922L (en) | 1977-09-18 |
| IT1063074B (en) | 1985-02-11 |
| CH631169A5 (en) | 1982-07-30 |
| FR2344545B1 (en) | 1980-03-21 |
| CA1081230A (en) | 1980-07-08 |
| DE2711149C3 (en) | 1980-12-11 |
| DK143558C (en) | 1982-03-22 |
| DE2711149A1 (en) | 1977-09-29 |
| NL166933C (en) | 1981-10-15 |
| JPS554746B2 (en) | 1980-01-31 |
| JPS52113983A (en) | 1977-09-24 |
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