ES458413A1 - Mejoras introducidas en un procedimiento de preparacion de -una composicion de anoxicilina sodica. - Google Patents
Mejoras introducidas en un procedimiento de preparacion de -una composicion de anoxicilina sodica.Info
- Publication number
- ES458413A1 ES458413A1 ES458413A ES458413A ES458413A1 ES 458413 A1 ES458413 A1 ES 458413A1 ES 458413 A ES458413 A ES 458413A ES 458413 A ES458413 A ES 458413A ES 458413 A1 ES458413 A1 ES 458413A1
- Authority
- ES
- Spain
- Prior art keywords
- sodium
- amoxicillin
- composition
- anoxicillin
- improvements introduced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
- 229910052708 sodium Inorganic materials 0.000 title 1
- 239000011734 sodium Substances 0.000 title 1
- 239000001488 sodium phosphate Substances 0.000 abstract 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 3
- 229910000406 trisodium phosphate Inorganic materials 0.000 abstract 3
- 235000019801 trisodium phosphate Nutrition 0.000 abstract 3
- BYHDFCISJXIVBV-YWUHCJSESA-M amoxicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=C(O)C=C1 BYHDFCISJXIVBV-YWUHCJSESA-M 0.000 abstract 2
- 229960002793 amoxicillin sodium Drugs 0.000 abstract 2
- ILVPFTMKCHREDJ-UHFFFAOYSA-N methyl 5-amino-2-fluorobenzoate Chemical group COC(=O)C1=CC(N)=CC=C1F ILVPFTMKCHREDJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 229960003022 amoxicillin Drugs 0.000 abstract 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Mejoras introducidas en un procedimiento de preparación de una composición de amoxicilina sódica, farmacéuticamente adecuada para su administración al hombre por inyección, que comprende la disolución de la amoxicilina sódica en agua o un disolvente acuoso en las condiciones adecuadas, caracterizadas dichas mejoras por agregar al disolvente fosfato trisódico, en cantidad suficiente para proporcionar una relación ponderal entre la amoxicilina sódica y el fosfato trisódico en cantidad suficiente para proporcionar una relación ponderal entre la amoxcilina sódica y el fosfato trisódico comprendida entre 8:1 y 50:1, que mejora la solubilidad de la amoxicilina en el disolvente para la administración parenteral del producto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB19652/76A GB1578337A (en) | 1976-05-13 | 1976-05-13 | Amoxycillin composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES458413A1 true ES458413A1 (es) | 1979-07-16 |
Family
ID=10132914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES458413A Expired ES458413A1 (es) | 1976-05-13 | 1977-05-03 | Mejoras introducidas en un procedimiento de preparacion de -una composicion de anoxicilina sodica. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4490383A (es) |
| JP (1) | JPS539313A (es) |
| AR (1) | AR211580A1 (es) |
| AT (1) | AT348680B (es) |
| BE (1) | BE854151A (es) |
| CA (1) | CA1110974A (es) |
| DE (1) | DE2721034A1 (es) |
| DK (1) | DK208777A (es) |
| ES (1) | ES458413A1 (es) |
| FI (1) | FI771451A7 (es) |
| FR (1) | FR2350844A1 (es) |
| GB (1) | GB1578337A (es) |
| GR (1) | GR63663B (es) |
| IE (1) | IE45193B1 (es) |
| IL (1) | IL51937A (es) |
| MX (1) | MX5053E (es) |
| NL (1) | NL7705200A (es) |
| NO (1) | NO148623C (es) |
| NZ (1) | NZ183924A (es) |
| PH (1) | PH16727A (es) |
| PT (1) | PT66465B (es) |
| SE (1) | SE442478B (es) |
| ZA (1) | ZA772495B (es) |
| ZM (1) | ZM3777A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2469179A1 (fr) * | 1979-11-08 | 1981-05-22 | Beecham Group Ltd | Composition pharmaceutique pour injection renfermant une penicilline |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1241844A (en) * | 1968-08-23 | 1971-08-04 | Beecham Group Ltd | Penicillins |
| GB1463563A (en) * | 1974-10-10 | 1977-02-02 | Beecham Group Ltd | Pharmaceutical compositions |
| JPS5283915A (en) * | 1976-01-01 | 1977-07-13 | Beecham Group Ltd | Amoxycillin solution |
-
1976
- 1976-05-13 GB GB19652/76A patent/GB1578337A/en not_active Expired
-
1977
- 1977-04-22 NZ NZ183924A patent/NZ183924A/xx unknown
- 1977-04-22 PT PT66465A patent/PT66465B/pt unknown
- 1977-04-25 IL IL51937A patent/IL51937A/xx unknown
- 1977-04-25 ZM ZM37/77A patent/ZM3777A1/xx unknown
- 1977-04-26 ZA ZA00772495A patent/ZA772495B/xx unknown
- 1977-04-27 CA CA277,171A patent/CA1110974A/en not_active Expired
- 1977-05-02 FR FR7713186A patent/FR2350844A1/fr active Granted
- 1977-05-03 GR GR53351A patent/GR63663B/el unknown
- 1977-05-03 ES ES458413A patent/ES458413A1/es not_active Expired
- 1977-05-06 FI FI771451A patent/FI771451A7/fi not_active Application Discontinuation
- 1977-05-10 SE SE7705471A patent/SE442478B/xx unknown
- 1977-05-10 DE DE19772721034 patent/DE2721034A1/de active Granted
- 1977-05-11 MX MX775732U patent/MX5053E/es unknown
- 1977-05-11 NL NL7705200A patent/NL7705200A/xx not_active Application Discontinuation
- 1977-05-11 AT AT337077A patent/AT348680B/de not_active IP Right Cessation
- 1977-05-11 PH PH19759A patent/PH16727A/en unknown
- 1977-05-12 NO NO771687A patent/NO148623C/no unknown
- 1977-05-12 IE IE965/77A patent/IE45193B1/en unknown
- 1977-05-12 JP JP5483877A patent/JPS539313A/ja active Pending
- 1977-05-12 DK DK208777A patent/DK208777A/da not_active Application Discontinuation
- 1977-05-13 AR AR267635A patent/AR211580A1/es active
- 1977-05-29 BE BE177176A patent/BE854151A/xx not_active IP Right Cessation
-
1982
- 1982-12-09 US US06/448,240 patent/US4490383A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BE854151A (fr) | 1977-10-31 |
| IE45193B1 (en) | 1982-07-14 |
| CA1110974A (en) | 1981-10-20 |
| NO148623C (no) | 1983-11-16 |
| PH16727A (en) | 1984-01-25 |
| NO771687L (no) | 1977-11-15 |
| ATA337077A (de) | 1978-07-15 |
| SE442478B (sv) | 1986-01-13 |
| ZM3777A1 (en) | 1978-07-21 |
| IL51937A0 (en) | 1977-06-30 |
| AR211580A1 (es) | 1978-01-30 |
| ZA772495B (en) | 1978-03-29 |
| NL7705200A (nl) | 1977-11-15 |
| SE7705471L (sv) | 1977-11-14 |
| GB1578337A (en) | 1980-11-05 |
| US4490383A (en) | 1984-12-25 |
| IL51937A (en) | 1980-05-30 |
| JPS539313A (en) | 1978-01-27 |
| DK208777A (da) | 1977-11-14 |
| GR63663B (en) | 1979-11-28 |
| IE45193L (en) | 1977-11-13 |
| FR2350844A1 (fr) | 1977-12-09 |
| PT66465A (en) | 1977-05-01 |
| DE2721034A1 (de) | 1977-12-01 |
| MX5053E (es) | 1983-03-08 |
| NO148623B (no) | 1983-08-08 |
| AT348680B (de) | 1979-02-26 |
| DE2721034C2 (es) | 1988-06-09 |
| FR2350844B1 (es) | 1981-05-29 |
| PT66465B (en) | 1978-09-27 |
| FI771451A7 (es) | 1977-11-14 |
| NZ183924A (en) | 1979-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980202 |