ES458748A1 - A PROCEDURE FOR THE PREPARATION OF PEPTIDIC DERIVATIVES. - Google Patents

A PROCEDURE FOR THE PREPARATION OF PEPTIDIC DERIVATIVES.

Info

Publication number
ES458748A1
ES458748A1 ES458748A ES458748A ES458748A1 ES 458748 A1 ES458748 A1 ES 458748A1 ES 458748 A ES458748 A ES 458748A ES 458748 A ES458748 A ES 458748A ES 458748 A1 ES458748 A1 ES 458748A1
Authority
ES
Spain
Prior art keywords
procedure
preparation
configuration
carbon atom
meaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES458748A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES458748A1 publication Critical patent/ES458748A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un procedimiento para la preparación de derivados peptídicos, de la fórmula general *** ver imagen 01 en donde n tiene un valor de 1, 2, 3. R1, R2 y R3 representan, cada uno, al grupo caracterizante de un alfa-aminoácido del tupo. R4 representa un grupo hidroxílico o metílico; La configuración en el átomo de carbono designado con (a) es D; La configuración en el átomo de carbono designado con (b) es I cuando R2 tiene un significado distinto a un átomo de hidrógeno; y La configuración en el átomo de carbono designado con (c) es (R) cuando R1 tiene un significado distinto a un átomo de hidrógeno.A procedure for the preparation of peptide derivatives, of the general formula *** see image 01 where n has a value of 1, 2, 3. R1, R2 and R3 each represent the characterizing group of an alpha-amino acid of the tube R4 represents a hydroxyl or methyl group; The configuration at the carbon atom designated (a) is D; The configuration at the carbon atom designated (b) is I when R2 has a meaning other than a hydrogen atom; and The configuration at the carbon atom designated by (c) is (R) when R1 has a meaning other than a hydrogen atom.

ES458748A 1976-05-14 1977-05-13 A PROCEDURE FOR THE PREPARATION OF PEPTIDIC DERIVATIVES. Expired ES458748A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB20014/76A GB1577232A (en) 1976-05-14 1976-05-14 Peptide derivatives of phosphonic and phosphinic acids

Publications (1)

Publication Number Publication Date
ES458748A1 true ES458748A1 (en) 1978-03-01

Family

ID=10138919

Family Applications (1)

Application Number Title Priority Date Filing Date
ES458748A Expired ES458748A1 (en) 1976-05-14 1977-05-13 A PROCEDURE FOR THE PREPARATION OF PEPTIDIC DERIVATIVES.

Country Status (23)

Country Link
JP (1) JPS52139023A (en)
AT (1) AT355740B (en)
AU (1) AU511452B2 (en)
BE (1) BE854591A (en)
CA (1) CA1090785A (en)
DE (1) DE2721760A1 (en)
DK (1) DK209877A (en)
ES (1) ES458748A1 (en)
FI (1) FI771518A7 (en)
FR (1) FR2351124A1 (en)
GB (1) GB1577232A (en)
GR (1) GR73010B (en)
IL (1) IL52040A (en)
IT (1) IT1075484B (en)
LU (1) LU77319A1 (en)
MC (1) MC1146A1 (en)
NL (1) NL7704370A (en)
NO (1) NO771717L (en)
NZ (1) NZ184047A (en)
PH (1) PH14715A (en)
PT (1) PT66544B (en)
SE (1) SE7705628L (en)
ZA (1) ZA772732B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002039A1 (en) * 1977-11-19 1979-05-30 Ciba-Geigy Ag Phosphonous acid derivatives, processes for their preparation and their use in combating microorganisms
DE2966111D1 (en) * 1978-10-05 1983-10-06 Ciba Geigy Ag Process for influencing plant growth
DE3368418D1 (en) * 1982-09-17 1987-01-29 Kyowa Hakko Kogyo Kk Phosphorus-containing peptide derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51639B1 (en) * 1971-07-28 1976-01-09
IL48835A (en) * 1975-01-27 1979-05-31 Sparamedica Ag Amino acyl and peptidyl derivatives of phophonic acids, their preparation and pharmaceutical compositions containingthem

Also Published As

Publication number Publication date
DE2721760A1 (en) 1977-12-01
PT66544A (en) 1977-06-01
CA1090785A (en) 1980-12-02
AU511452B2 (en) 1980-08-21
MC1146A1 (en) 1978-01-30
ATA345877A (en) 1979-08-15
NO771717L (en) 1977-11-15
IL52040A (en) 1979-11-30
IL52040A0 (en) 1977-07-31
AT355740B (en) 1980-03-25
ZA772732B (en) 1978-04-26
IT1075484B (en) 1985-04-22
LU77319A1 (en) 1978-06-26
GB1577232A (en) 1980-10-22
NL7704370A (en) 1977-11-16
JPS52139023A (en) 1977-11-19
GR73010B (en) 1984-01-24
FR2351124B1 (en) 1981-02-13
PH14715A (en) 1981-11-13
AU2500877A (en) 1978-11-16
FR2351124A1 (en) 1977-12-09
BE854591A (en) 1977-11-14
PT66544B (en) 1979-04-12
DK209877A (en) 1977-11-15
FI771518A7 (en) 1977-11-15
NZ184047A (en) 1980-04-28
SE7705628L (en) 1977-11-15

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