ES459655A1 - Procedimiento para la obtencion de compuestos cefem. - Google Patents

Procedimiento para la obtencion de compuestos cefem.

Info

Publication number
ES459655A1
ES459655A1 ES459655A ES459655A ES459655A1 ES 459655 A1 ES459655 A1 ES 459655A1 ES 459655 A ES459655 A ES 459655A ES 459655 A ES459655 A ES 459655A ES 459655 A1 ES459655 A1 ES 459655A1
Authority
ES
Spain
Prior art keywords
intermediates
salts
formula
derivs
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES459655A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES459655A1 publication Critical patent/ES459655A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Procedimiento para la obtención de derivados de cefem de fórmula general I **(Fórmula 01)** donde Ac significa un grupo acilo, R significa -OCOCH3 o -Shet y Het significa un resto heteroaromático, así como de sus ésteres fácilmente disociables y de las sales fisiológicamente compatibles de estos compuestos por reacción consecutiva de un derivado de la cefaloesporina C con un agente de sililización, un agente de iminohalogenación, un agente de iminoeteración y un agente de acilación, así como hidrólisis a continuación, caracterizado porque como derivado de la cefaloesporina C se emplea un compuesto de fórmula general II **(Fórmula 02)** donde R tiene el significado arriba indicado, o un éster fácilmente disociable, o una sal de uno de estos compuestos.
ES459655A 1976-06-10 1977-06-10 Procedimiento para la obtencion de compuestos cefem. Expired ES459655A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762626026 DE2626026A1 (de) 1976-06-10 1976-06-10 Verfahren zur herstellung von cephemderivaten

Publications (1)

Publication Number Publication Date
ES459655A1 true ES459655A1 (es) 1978-10-01

Family

ID=5980239

Family Applications (1)

Application Number Title Priority Date Filing Date
ES459655A Expired ES459655A1 (es) 1976-06-10 1977-06-10 Procedimiento para la obtencion de compuestos cefem.

Country Status (7)

Country Link
JP (1) JPS52151192A (es)
DE (1) DE2626026A1 (es)
ES (1) ES459655A1 (es)
FR (1) FR2354332A1 (es)
IT (1) IT1078470B (es)
NL (1) NL7706400A (es)
SE (1) SE7706725L (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004538265A (ja) * 2001-04-19 2004-12-24 ビオフェルマ ムルシア，エス．アー． α−ケト酸誘導体を使用して３−セファロスポラン酸誘導体を製造する方法
CN105017286B (zh) * 2015-07-09 2017-11-28 山东罗欣药业集团股份有限公司 一种头孢类抗感染药物的制备方法

Also Published As

Publication number Publication date
FR2354332A1 (fr) 1978-01-06
NL7706400A (nl) 1977-12-13
IT1078470B (it) 1985-05-08
SE7706725L (sv) 1977-12-11
JPS52151192A (en) 1977-12-15
DE2626026A1 (de) 1977-12-22

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