ES459865A1 - Procedimiento para preparar nuevos derivados de indol. - Google Patents

Procedimiento para preparar nuevos derivados de indol.

Info

Publication number
ES459865A1
ES459865A1 ES459865A ES459865A ES459865A1 ES 459865 A1 ES459865 A1 ES 459865A1 ES 459865 A ES459865 A ES 459865A ES 459865 A ES459865 A ES 459865A ES 459865 A1 ES459865 A1 ES 459865A1
Authority
ES
Spain
Prior art keywords
radical
methyl
same
indole derivatives
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES459865A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Publication of ES459865A1 publication Critical patent/ES459865A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Procedimiento para preparar derivados del indol, de fórmula general: *(ver fórmula 1)*, y sus sales de adición de ácido farmacéuticamente aceptables, en cuya fórmula R1 es un átomo de hidrógeno o un radical metilo, R2 y R3, que son iguales o diferentes, son cada uno un átomo de hidrógeno, un radical metilo o etilo, un radical bencilo o representan juntos una cadena pentametileno, hexametileno, oxidietileno o N-metilaminodietileno, formando así un ciclo con el átomo de nitrógeno, R4 es un radical fenilo, 2',3'-dimetilfenilo, isopropilo, ciclopropilo, 1-metil-ciclopropilo, ciclopentilo o ciclohexilo.
ES459865A 1976-06-17 1977-06-17 Procedimiento para preparar nuevos derivados de indol. Expired ES459865A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7618364A FR2354766A1 (fr) 1976-06-17 1976-06-17 Derives n-aminoalkyles d'indole et procedes pour les preparer

Publications (1)

Publication Number Publication Date
ES459865A1 true ES459865A1 (es) 1978-04-01

Family

ID=9174512

Family Applications (1)

Application Number Title Priority Date Filing Date
ES459865A Expired ES459865A1 (es) 1976-06-17 1977-06-17 Procedimiento para preparar nuevos derivados de indol.

Country Status (10)

Country Link
US (1) US4139634A (es)
JP (1) JPS5340765A (es)
BE (1) BE855761A (es)
CH (1) CH599937A5 (es)
DE (1) DE2727047A1 (es)
ES (1) ES459865A1 (es)
FR (1) FR2354766A1 (es)
GB (1) GB1564455A (es)
IT (1) IT1114805B (es)
NL (1) NL7706286A (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2931323A1 (de) 1979-08-02 1981-02-26 Kali Chemie Pharma Gmbh Neue n-aminoalkylindol-derivate und ihre salze
US4448784A (en) * 1982-04-12 1984-05-15 Hoechst-Roussel Pharmaceuticals, Inc. 1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof
US4539410A (en) * 1982-09-30 1985-09-03 Ciba-Geigy Corporation N-Substituted-2-(1-imidazolyl)indoles
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof
DE3821148A1 (de) * 1988-06-23 1989-12-28 Erwin Von Dr Angerer Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
DK181190D0 (da) * 1990-07-30 1990-07-30 Lundbeck & Co As H 3-aryl-indol- eller 3-aryl-indazolderivater
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
US5538973A (en) * 1992-03-27 1996-07-23 Kyoto Pharmaceutical Industries, Ltd. Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
WO1997021707A1 (en) 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6200957B1 (en) 1995-12-14 2001-03-13 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP1632491A1 (en) 2004-08-30 2006-03-08 Laboratorios Del Dr. Esteve, S.A. Substituted indole compounds and their use as 5-HT6 receptor modulators
US20070213359A1 (en) * 2005-12-30 2007-09-13 Acadia Pharmaceuticals Inc. Bicyclic-nitrogen compounds as modulators of ghrelin receptor and uses thereof
EP2078711A1 (en) 2007-12-28 2009-07-15 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT224635B (de) * 1959-09-14 1962-12-10 Dumex Ltd As Verfahren zur Herstellung von neuen Indolderivaten und von deren Salzen
US3503990A (en) * 1967-01-31 1970-03-31 Endo Lab 6-aryl-4,5,6,7-tetrahydro-4-oxoindole derivatives

Also Published As

Publication number Publication date
BE855761A (fr) 1977-12-16
FR2354766A1 (fr) 1978-01-13
IT1114805B (it) 1986-01-27
JPS5340765A (en) 1978-04-13
CH599937A5 (es) 1978-06-15
FR2354766B1 (es) 1978-11-17
DE2727047A1 (de) 1977-12-29
GB1564455A (en) 1980-04-10
NL7706286A (nl) 1977-12-20
US4139634A (en) 1979-02-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990601