ES461037A1 - Un procedimiento para la preparacion de derivados tiofeno. - Google Patents
Un procedimiento para la preparacion de derivados tiofeno.Info
- Publication number
- ES461037A1 ES461037A1 ES461037A ES461037A ES461037A1 ES 461037 A1 ES461037 A1 ES 461037A1 ES 461037 A ES461037 A ES 461037A ES 461037 A ES461037 A ES 461037A ES 461037 A1 ES461037 A1 ES 461037A1
- Authority
- ES
- Spain
- Prior art keywords
- inflammatory
- formula
- thiophene derivatives
- compounds
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 150000003577 thiophenes Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Rheumatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Esta invención proporciona una composición farmacéutica que contiene un compuesto de fórmula (I) y un vehículo farmacéuticamente aceptable. Normalmente la composición de esta invención es adecuada para administración oral. La composición puede presentarse en forma de dosis convencional como tabletas, cápsulas, papelillos de polvo reconstituíble o similares. En el caso más adecuado, la composición se presenta en forma de dosis unitaria que contiene de 20 a 600 mg de un compuesto de la invención, v.g. de 50 a 40 mg. Estas composiciones pueden ser administradas una o más veces al día de manera que la dosis diaria total para un adulto de 70 kg será del orden de 40 a 1200 mg, por ejemplo de 100 a 600 mg. Las composiciones pueden prepararse de forma convencional por mezclado, llenado, formación de tabletas y similares y las composiciones pueden contener excipientes convencionales como lubricantes, desintegrantes, ligantes, cargas, agentes colorantes, aromatizantes y similares. Las composiciones pueden ser formuladas de la forma descrita para agentes anti inflamatorios conocidos como la indometacina, anproxen, cetoprofen, fenilbutazona o similares.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB31852/76A GB1525434A (en) | 1976-07-30 | 1976-07-30 | Anti-inflammatory thiophene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES461037A1 true ES461037A1 (es) | 1978-12-01 |
Family
ID=10329363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES461037A Expired ES461037A1 (es) | 1976-07-30 | 1977-07-26 | Un procedimiento para la preparacion de derivados tiofeno. |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5318558A (es) |
| AT (1) | AT361466B (es) |
| AU (1) | AU507121B2 (es) |
| BE (1) | BE857128A (es) |
| CA (1) | CA1078400A (es) |
| CH (1) | CH636613A5 (es) |
| DE (1) | DE2733683A1 (es) |
| DK (1) | DK339877A (es) |
| ES (1) | ES461037A1 (es) |
| FR (1) | FR2359837A1 (es) |
| GB (1) | GB1525434A (es) |
| IE (1) | IE45325B1 (es) |
| IL (1) | IL52503A (es) |
| NL (1) | NL7708062A (es) |
| SE (1) | SE7708591L (es) |
| ZA (1) | ZA774222B (es) |
-
1976
- 1976-07-29 CA CA283,755A patent/CA1078400A/en not_active Expired
- 1976-07-30 GB GB31852/76A patent/GB1525434A/en not_active Expired
-
1977
- 1977-07-11 IL IL52503A patent/IL52503A/xx unknown
- 1977-07-14 ZA ZA00774222A patent/ZA774222B/xx unknown
- 1977-07-20 NL NL7708062A patent/NL7708062A/xx not_active Application Discontinuation
- 1977-07-25 FR FR7722739A patent/FR2359837A1/fr active Granted
- 1977-07-25 CH CH919577A patent/CH636613A5/de not_active IP Right Cessation
- 1977-07-25 BE BE179615A patent/BE857128A/xx unknown
- 1977-07-26 ES ES461037A patent/ES461037A1/es not_active Expired
- 1977-07-26 DE DE19772733683 patent/DE2733683A1/de not_active Withdrawn
- 1977-07-26 SE SE7708591A patent/SE7708591L/xx not_active Application Discontinuation
- 1977-07-27 DK DK339877A patent/DK339877A/da not_active Application Discontinuation
- 1977-07-29 JP JP9053877A patent/JPS5318558A/ja active Pending
- 1977-07-29 AT AT560477A patent/AT361466B/de not_active IP Right Cessation
- 1977-07-29 IE IE1585/77A patent/IE45325B1/en unknown
- 1977-07-29 AU AU27471/77A patent/AU507121B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE45325L (en) | 1978-01-30 |
| JPS5318558A (en) | 1978-02-20 |
| ATA560477A (de) | 1980-08-15 |
| BE857128A (fr) | 1978-01-25 |
| DE2733683A1 (de) | 1978-02-02 |
| AU507121B2 (en) | 1980-02-07 |
| CH636613A5 (en) | 1983-06-15 |
| IL52503A (en) | 1981-06-29 |
| SE7708591L (sv) | 1978-01-31 |
| NL7708062A (nl) | 1978-02-01 |
| DK339877A (da) | 1978-01-31 |
| GB1525434A (en) | 1978-09-20 |
| FR2359837B1 (es) | 1980-04-04 |
| AU2747177A (en) | 1979-02-01 |
| FR2359837A1 (fr) | 1978-02-24 |
| ZA774222B (en) | 1978-06-28 |
| AT361466B (de) | 1981-03-10 |
| IE45325B1 (en) | 1982-07-28 |
| IL52503A0 (en) | 1977-10-31 |
| CA1078400A (en) | 1980-05-27 |
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