ES461608A1 - Un procedimiento para preparar n-(6-(r3r4n)-4 (o 5)-r5-3-pi-ridazinil) aminometilenmalonato de alquilidenilo ciclico. - Google Patents
Un procedimiento para preparar n-(6-(r3r4n)-4 (o 5)-r5-3-pi-ridazinil) aminometilenmalonato de alquilidenilo ciclico.Info
- Publication number
- ES461608A1 ES461608A1 ES461608A ES461608A ES461608A1 ES 461608 A1 ES461608 A1 ES 461608A1 ES 461608 A ES461608 A ES 461608A ES 461608 A ES461608 A ES 461608A ES 461608 A1 ES461608 A1 ES 461608A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridazinyl
- cyclic
- r3r4n
- alkylidenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004122 cyclic group Chemical group 0.000 title abstract 7
- DTFBBVDDPVULMK-UHFFFAOYSA-N 2-(aminomethylidene)propanedioic acid Chemical class NC=C(C(O)=O)C(O)=O DTFBBVDDPVULMK-UHFFFAOYSA-N 0.000 title 1
- 230000001843 schistosomicidal effect Effects 0.000 abstract 3
- YUEFAYDMKQSOAI-UHFFFAOYSA-N 2-[[[6-(methylamino)pyridazin-3-yl]amino]methylidene]propanedioic acid Chemical compound CNC1=NN=C(C=C1)NC=C(C(=O)O)C(=O)O YUEFAYDMKQSOAI-UHFFFAOYSA-N 0.000 abstract 2
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- -1 isopropylidenyl Chemical group 0.000 abstract 2
- DJDDYWYYTKNZPM-UHFFFAOYSA-N 2-amino-1,3-dioxane-4,6-dione Chemical compound NC1OC(=O)CC(=O)O1 DJDDYWYYTKNZPM-UHFFFAOYSA-N 0.000 abstract 1
- 241000242678 Schistosoma Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000004409 schistosomiasis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un procedimiento para preparar N-[6-(R3R4N)-4(ó 5)-R5-3- piridazinil]aminometilenmalonato de alquilidenilo cíclico que tiene la fórmula I (en la presente) en donde R1 y R2 son cada uno alquilo inferior que tiene de uno a tres átomos de carbono; R3 y R4 son cada uno alquilo inferior que tiene de uno a tres átomos de carbono o R3R4N es 1-piperidinilo, 1- pirrolidinilo, 4-metil-1-piperazinilo, 4-morfolinilo ó 4- morfolinilo que tiene de uno a cuatro substituyentes de alquilo en el átomo de carbono en el anillo, que se seleccionan de metilo, etilo, n-propilo e isopropilo con el número total de átomos de carbono del substituyente o substituyentes de alquilo siendo de uno a cuatro; y R5 es hidrógeno o alquilo inferior que tiene de uno a tres átomos de carbono; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71569976A | 1976-08-19 | 1976-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES461608A1 true ES461608A1 (es) | 1978-12-01 |
Family
ID=24875128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES461608A Expired ES461608A1 (es) | 1976-08-19 | 1977-08-16 | Un procedimiento para preparar n-(6-(r3r4n)-4 (o 5)-r5-3-pi-ridazinil) aminometilenmalonato de alquilidenilo ciclico. |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4104385A (es) |
| BE (1) | BE857979A (es) |
| ES (1) | ES461608A1 (es) |
| ZA (1) | ZA774870B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5001125A (en) * | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
| FR2903985B1 (fr) | 2006-07-24 | 2008-09-05 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2904316B1 (fr) | 2006-07-31 | 2008-09-05 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique. |
| KR102066297B1 (ko) | 2011-10-14 | 2020-01-14 | 암비트 바이오사이언시즈 코포레이션 | 헤테로사이클릭 화합물 및 이의 유형 3 수용체 티로신 키나아제의 조절인자로서의 용도 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1147759A (en) * | 1965-06-17 | 1969-04-10 | Sterling Drug Inc | Aromatic derivatives and preparation thereof |
-
1977
- 1977-06-10 US US05/805,419 patent/US4104385A/en not_active Expired - Lifetime
- 1977-08-11 ZA ZA00774870A patent/ZA774870B/xx unknown
- 1977-08-16 ES ES461608A patent/ES461608A1/es not_active Expired
- 1977-08-19 BE BE1008335A patent/BE857979A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE857979A (fr) | 1978-02-20 |
| ZA774870B (en) | 1978-06-28 |
| US4104385A (en) | 1978-08-01 |
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