ES462990A1 - Un procedimiento para la preparacion del yoduro de 2-(2-fu- roil)-1,4-dimetilpiridinio - Google Patents

Un procedimiento para la preparacion del yoduro de 2-(2-fu- roil)-1,4-dimetilpiridinio

Info

Publication number
ES462990A1
ES462990A1 ES462990A ES462990A ES462990A1 ES 462990 A1 ES462990 A1 ES 462990A1 ES 462990 A ES462990 A ES 462990A ES 462990 A ES462990 A ES 462990A ES 462990 A1 ES462990 A1 ES 462990A1
Authority
ES
Spain
Prior art keywords
furoyl
methylpyridine
methyl iodide
quaternary salt
iodide quaternary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES462990A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Made SA
Original Assignee
Laboratorios Made SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Made SA filed Critical Laboratorios Made SA
Priority to ES462990A priority Critical patent/ES462990A1/es
Priority to GB7839498A priority patent/GB2005273B/en
Priority to DE19782843495 priority patent/DE2843495A1/de
Priority to US05/949,021 priority patent/US4173705A/en
Priority to PT68627A priority patent/PT68627A/pt
Priority to CH1041878A priority patent/CH638518A5/de
Priority to JP12349378A priority patent/JPS5479284A/ja
Priority to FR7828583A priority patent/FR2405255B1/fr
Publication of ES462990A1 publication Critical patent/ES462990A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un procedimiento para la preparación del yoduro de 2-(2- furoil)¿1,4-dimetilpiridinio de fórmula I. **(Fórmula)** caracterizado porque en una primera etapa de síntesis se hace reaccionar bajo atmósfera de nitrógeno, la 2-ciano-4- metilpiridina con una disolución etérea de 2-furil-litio recientemente preparado, y porque tras de una hidrólisis ácida se obtiene la 2-(2-furoil)-4-metilpiridina (II). **(Fórmula)** la cual por calentamiento en presencia de un halógenuro de metilo, por ejemplo el ioduro de metilo, se convierte en el compuesto de fórmula I.
ES462990A 1977-10-07 1977-10-07 Un procedimiento para la preparacion del yoduro de 2-(2-fu- roil)-1,4-dimetilpiridinio Expired ES462990A1 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES462990A ES462990A1 (es) 1977-10-07 1977-10-07 Un procedimiento para la preparacion del yoduro de 2-(2-fu- roil)-1,4-dimetilpiridinio
GB7839498A GB2005273B (en) 1977-10-07 1978-10-05 Pyridine compounds and corresponding methyl halides methods of preparation and pharmaceutical compositions containing the same
DE19782843495 DE2843495A1 (de) 1977-10-07 1978-10-05 2-(2-furoyl)-1,4-dimethylpyridin, 2-(2-furoyl)-1,4-dimethylpyridiniumjodid und verfahren zu ihrer herstellung
US05/949,021 US4173705A (en) 1977-10-07 1978-10-06 2-(2-Furoyl)-4-methylpyridine and its methyl iodide quaternary salt
PT68627A PT68627A (en) 1977-10-07 1978-10-06 Process for the preparation of 2-(2-furoyl)-1,4-dimethyl-pyridinium iodide
CH1041878A CH638518A5 (de) 1977-10-07 1978-10-06 2-(2-furoyl)-4-methylpyridin und verfahren zu seiner herstellung.
JP12349378A JPS5479284A (en) 1977-10-07 1978-10-06 22*22furoyl**1*44dimethyl pyridinium iodide and its manufacture
FR7828583A FR2405255B1 (fr) 1977-10-07 1978-10-06 L'iodure de 2-(2-furoyl)-1,4-dimethylpyridinium, son procede de preparation, et son application en tant que medicament

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES462990A ES462990A1 (es) 1977-10-07 1977-10-07 Un procedimiento para la preparacion del yoduro de 2-(2-fu- roil)-1,4-dimetilpiridinio

Publications (1)

Publication Number Publication Date
ES462990A1 true ES462990A1 (es) 1979-01-01

Family

ID=8474648

Family Applications (1)

Application Number Title Priority Date Filing Date
ES462990A Expired ES462990A1 (es) 1977-10-07 1977-10-07 Un procedimiento para la preparacion del yoduro de 2-(2-fu- roil)-1,4-dimetilpiridinio

Country Status (8)

Country Link
US (1) US4173705A (es)
JP (1) JPS5479284A (es)
CH (1) CH638518A5 (es)
DE (1) DE2843495A1 (es)
ES (1) ES462990A1 (es)
FR (1) FR2405255B1 (es)
GB (1) GB2005273B (es)
PT (1) PT68627A (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5495828A (en) * 1978-01-10 1979-07-28 Nissan Motor Co Ltd Exhaust recirculation system of internal combustion engine
KR102560825B1 (ko) * 2018-04-30 2023-07-31 현대자동차주식회사 리튬 이차전지 및 그 제조방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792042A (fr) * 1971-11-30 1973-05-29 Ciba Geigy Procede de preparation de nouvelles alcenylene-amines substituees en 3

Also Published As

Publication number Publication date
FR2405255A1 (fr) 1979-05-04
FR2405255B1 (fr) 1985-10-04
GB2005273B (en) 1982-02-17
GB2005273A (en) 1979-04-19
DE2843495A1 (de) 1979-04-12
JPS5479284A (en) 1979-06-25
CH638518A5 (de) 1983-09-30
PT68627A (en) 1978-11-01
US4173705A (en) 1979-11-06

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