ES463684A1 - Un procedimiento para preparar nuevos derivados de aminogli-cosido. - Google Patents
Un procedimiento para preparar nuevos derivados de aminogli-cosido.Info
- Publication number
- ES463684A1 ES463684A1 ES463684A ES463684A ES463684A1 ES 463684 A1 ES463684 A1 ES 463684A1 ES 463684 A ES463684 A ES 463684A ES 463684 A ES463684 A ES 463684A ES 463684 A1 ES463684 A1 ES 463684A1
- Authority
- ES
- Spain
- Prior art keywords
- aminoglycoside antibiotic
- antibiotic derivatives
- derivatives
- aminoglycosidesx
- deoxystreptamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002647 aminoglycoside antibiotic agent Substances 0.000 title abstract 2
- 229940126574 aminoglycoside antibiotic Drugs 0.000 title 1
- DTFAJAKTSMLKAT-JDCCYXBGSA-N 2-deoxystreptamine Chemical group N[C@H]1C[C@@H](N)[C@H](O)[C@@H](O)[C@@H]1O DTFAJAKTSMLKAT-JDCCYXBGSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000837 carbohydrate group Chemical group 0.000 abstract 1
- 229960000318 kanamycin Drugs 0.000 abstract 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
- 229930182823 kanamycin A Natural products 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Un procedimiento para preparar nuevos derivados de aminoglicósido y sus sales representados por la fórmula: ***(ver fórmula) (en donde R es un átomo de hidrógeno, alcohilo de C1 a C5 o aralcohilo de C7 a C10; R1 es aminometilo, hidroximetilo, metilaminometilo o 1-metilaminoetilo; R2, R3 y R6 representan independientemente un átomo de hidrógeno o hidroxi; R4 es hidroxi o amino, R5 es amino o metilamino; R7 es hidroxi o metilo; R8 es un átomo de hidrógeno, hidroximetilo o carbamoiloximetilo; la línea de puntos representa la presencia o ausencia de un doble enlace; n es el número entero 1 ó 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13011976A JPS5356661A (en) | 1976-10-28 | 1976-10-28 | Novel amino glycoside antibiotics derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES463684A1 true ES463684A1 (es) | 1978-07-01 |
Family
ID=15026393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES463684A Expired ES463684A1 (es) | 1976-10-28 | 1977-10-28 | Un procedimiento para preparar nuevos derivados de aminogli-cosido. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4166114A (es) |
| JP (1) | JPS5356661A (es) |
| AR (1) | AR221833A1 (es) |
| AT (1) | AT348125B (es) |
| AU (1) | AU512230B2 (es) |
| BE (1) | BE860048A (es) |
| CA (1) | CA1085830A (es) |
| DD (1) | DD133146A5 (es) |
| DE (1) | DE2748257A1 (es) |
| DK (1) | DK478677A (es) |
| ES (1) | ES463684A1 (es) |
| FI (1) | FI773229A7 (es) |
| FR (1) | FR2369295A1 (es) |
| GB (1) | GB1583366A (es) |
| GR (1) | GR61696B (es) |
| HU (1) | HU177261B (es) |
| IE (1) | IE45788B1 (es) |
| IL (1) | IL53208A (es) |
| MX (1) | MX4324E (es) |
| NL (1) | NL7711843A (es) |
| NZ (1) | NZ185168A (es) |
| PH (1) | PH14183A (es) |
| PL (1) | PL105730B1 (es) |
| PT (1) | PT67134B (es) |
| RO (1) | RO73517A (es) |
| SE (1) | SE7711992L (es) |
| SU (1) | SU724086A3 (es) |
| ZA (1) | ZA775314B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1105455A (en) * | 1977-09-19 | 1981-07-21 | Junji Irisawa | Aminoglycoside derivatives |
| JPS5461151A (en) * | 1977-10-25 | 1979-05-17 | Shionogi & Co Ltd | Novel aminoglycoside derivative |
| JPS5492951A (en) * | 1977-12-29 | 1979-07-23 | Shionogi & Co Ltd | Novel aminoglycoside derivative |
| JPS5538345A (en) * | 1978-09-11 | 1980-03-17 | Shionogi & Co Ltd | Novel aminoglycoside derivative |
| JPS5540621A (en) * | 1978-09-14 | 1980-03-22 | Shionogi & Co Ltd | Novel aminoglycoside derivative |
| JPS5629598A (en) * | 1979-08-18 | 1981-03-24 | Toyo Jozo Co Ltd | Novel amino sugar antibiotic g-367-2 and its preparation |
| US4424345A (en) | 1980-09-22 | 1984-01-03 | Eli Lilly And Company | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process |
| US4424344A (en) | 1980-09-22 | 1984-01-03 | Eli Lilly And Company | 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process |
| US4468512A (en) * | 1980-09-22 | 1984-08-28 | Eli Lilly And Company | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides |
| US4468513A (en) * | 1980-09-22 | 1984-08-28 | Eli Lilly And Company | 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides |
| JPS63224488A (ja) * | 1987-03-12 | 1988-09-19 | Sony Corp | 時間軸圧縮伸長装置 |
| DE10042853A1 (de) * | 2000-08-30 | 2002-04-25 | Florian Lang | Nachweis und Beeinflußung der Expression oder Funktion von CD95/CD95L bei Infektionen |
| US7794713B2 (en) | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
| US7862812B2 (en) | 2006-05-31 | 2011-01-04 | Lpath, Inc. | Methods for decreasing immune response and treating immune conditions |
| CN101868472B (zh) * | 2007-11-21 | 2013-05-29 | 尔察祯有限公司 | 抗菌性氨基糖苷类似物 |
| WO2010132757A2 (en) * | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010132765A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010132768A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of sisomicin |
| WO2010132759A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of dibekacin |
| WO2010132760A1 (en) * | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of tobramycin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3929762A (en) * | 1972-08-23 | 1975-12-30 | Microbial Chem Res Found | 3{40 -Deoxy derivatives of neamine and its related aminoglycosidic antibiotics, and the production thereof |
| US3920628A (en) * | 1972-10-24 | 1975-11-18 | Schering Corp | 2{41 -Deoxyaminoglycosides and 2{41 -epi-amino-3{41 -desamino derivatives thereof, methods for their manufacture and novel intermediates useful therein |
| US3965089A (en) * | 1973-03-12 | 1976-06-22 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Process for the production of a cyclic ureido-derivative of a deoxystreptamine-containing antibiotic and products thereof |
-
1976
- 1976-10-28 JP JP13011976A patent/JPS5356661A/ja active Pending
-
1977
- 1977-09-02 ZA ZA00775314A patent/ZA775314B/xx unknown
- 1977-09-09 CA CA286,380A patent/CA1085830A/en not_active Expired
- 1977-09-12 NZ NZ185168A patent/NZ185168A/xx unknown
- 1977-09-29 US US05/837,909 patent/US4166114A/en not_active Expired - Lifetime
- 1977-10-04 GB GB41236/77A patent/GB1583366A/en not_active Expired
- 1977-10-06 IE IE2045/77A patent/IE45788B1/en unknown
- 1977-10-10 PT PT67134A patent/PT67134B/pt unknown
- 1977-10-19 GR GR54608A patent/GR61696B/el unknown
- 1977-10-19 HU HU77SI1600A patent/HU177261B/hu unknown
- 1977-10-19 AU AU29865/77A patent/AU512230B2/en not_active Expired
- 1977-10-21 IL IL53208A patent/IL53208A/xx unknown
- 1977-10-24 MX MX776500U patent/MX4324E/es unknown
- 1977-10-24 BE BE182006A patent/BE860048A/xx unknown
- 1977-10-25 PL PL1977201732A patent/PL105730B1/pl unknown
- 1977-10-25 SE SE7711992A patent/SE7711992L/xx unknown
- 1977-10-26 RO RO7791946A patent/RO73517A/ro unknown
- 1977-10-26 DD DD7700201707A patent/DD133146A5/xx unknown
- 1977-10-27 AR AR269675A patent/AR221833A1/es active
- 1977-10-27 FR FR7732490A patent/FR2369295A1/fr active Granted
- 1977-10-27 DK DK478677A patent/DK478677A/da not_active Application Discontinuation
- 1977-10-27 NL NL7711843A patent/NL7711843A/xx not_active Application Discontinuation
- 1977-10-27 DE DE19772748257 patent/DE2748257A1/de not_active Withdrawn
- 1977-10-27 SU SU772535803A patent/SU724086A3/ru active
- 1977-10-28 FI FI773229A patent/FI773229A7/fi not_active Application Discontinuation
- 1977-10-28 PH PH20386A patent/PH14183A/en unknown
- 1977-10-28 AT AT771277A patent/AT348125B/de not_active IP Right Cessation
- 1977-10-28 ES ES463684A patent/ES463684A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| PT67134A (en) | 1977-11-01 |
| IL53208A0 (en) | 1977-12-30 |
| FR2369295B1 (es) | 1980-01-18 |
| CA1085830A (en) | 1980-09-16 |
| NZ185168A (en) | 1980-10-24 |
| JPS5356661A (en) | 1978-05-23 |
| AU512230B2 (en) | 1980-10-02 |
| PT67134B (en) | 1979-03-16 |
| MX4324E (es) | 1982-03-24 |
| SE7711992L (sv) | 1978-04-29 |
| DK478677A (da) | 1978-04-29 |
| US4166114A (en) | 1979-08-28 |
| HU177261B (en) | 1981-08-28 |
| RO73517A (ro) | 1980-11-30 |
| PL105730B1 (pl) | 1979-10-31 |
| ZA775314B (en) | 1978-07-26 |
| FR2369295A1 (fr) | 1978-05-26 |
| SU724086A3 (ru) | 1980-03-25 |
| IE45788L (en) | 1978-04-28 |
| AU2986577A (en) | 1979-04-26 |
| NL7711843A (nl) | 1978-05-03 |
| DE2748257A1 (de) | 1978-05-03 |
| IE45788B1 (en) | 1982-12-01 |
| PL201732A1 (pl) | 1978-07-17 |
| IL53208A (en) | 1981-05-20 |
| BE860048A (fr) | 1978-04-24 |
| GR61696B (en) | 1978-12-11 |
| AT348125B (de) | 1979-01-25 |
| DD133146A5 (de) | 1978-12-13 |
| AR221833A1 (es) | 1981-03-31 |
| GB1583366A (en) | 1981-01-28 |
| FI773229A7 (fi) | 1978-04-29 |
| ATA771277A (de) | 1978-06-15 |
| PH14183A (en) | 1981-03-26 |
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